How pharmacoepidemiology networks can manage distributed analyses to improve replicability and transparency and minimize bias

Several pharmacoepidemiology networks have been developed over the past decade that use a distributed approach, implementing the same analysis at multiple data sites, to preserve privacy and minimize data sharing. Distributed networks are efficient, by interrogating data on very large populations. The structure of these networks can also be leveraged to improve replicability, increase transparency, and reduce bias. We describe some features of distributed networks using, as examples, the Canadian Network for Observational Drug Effect Studies, the Sentinel System in the USA, and the European Research Network of Pharmacovigilance and Pharmacoepidemiology. Common protocols, analysis plans, and data models, with policies on amendments and protocol violations, are key features. These tools ensure that studies can be audited and repeated as necessary. Blinding and strict conflict of interest policies reduce the potential for bias in analyses and interpretation. These developments should improve the timeliness and accuracy of information used to support both clinical and regulatory decisions

Tracking Middleboxes in the Mobile World with TraceboxAndroid

peer reviewedMiddleboxes are largely deployed over cellular networks. It is known that they might disrupt network performance, expose users to security issues, and harm protocols deployability. Further, hardly any network measurements tools for smartphones are able to infer middlebox behaviors, specially if one cannot control both ends of a path. In this paper, we present TraceboxAndroid a proof-of-concept measurement application for Android mobile devices implementing the tracebox algorithm. It aims at diagnosing middlebox-impaired paths by detecting and locating rewriting middleboxes. We analyze a dataset sample to highlight the range of opportunities offered by TraceboxAndroid. We show that TraceboxAndroid can be useful for mobile users as well as for the research community

A Flexible and Modular Framework for Implementing Infrastructures for Global Computing

We present a Java software framework for building infrastructures to support the development of applications for systems where mobility and network awareness are key issues. The framework is particularly useful to develop run-time support for languages oriented towards global computing. It enables platform designers to customize communication protocols and network architectures and guarantees transparency of name management and code mobility in distributed environments. The key features are illustrated by means of a couple of simple case studies

An Integrated environment for data acquisition with dynamic changes in wireless sensor networks

The wireless sensor network (WSN) is an important technology with a wide variety of diverse applications in such domains as healthcare, military forces and environmental monitoring. Our research aims at developing methods and tools capable of addressing WSN problems such as energy constraint, low memory, and computation capability of a sensor node by implementing a new WSN design concept, improving existing and developing new protocols. Our research goal is to develop novel generic methodologies supporting a higher level of design flexibility and possible architectural optimization against multiple criteria such as the quality of data (QoD), quality of service (QoS), and lifetime extension. Application requirements may vary in terms of abovementioned parameters and consequently there is no single platform that can be applied to all domains. Moreover, current methods do not provide opportunities for dynamic changes of either protocols or their parameters, which might improve WSN agility and survivability in a harsh environment. This problem can be solved by integrating various protocols at different layers within a single framework and supporting their dynamic selection in order to adapt the network to varying application requirements. This thesis develops a mechanism which facilitates structural design and implementation of an Integrated Environment for Data Acquisition with Dynamic Changes (IEDADC). It features adaptation and integration of protocols, protocol switching and automatic or manual selection as well as the implementation of quality assurance and localization techniques. The design methodology is tested by implementing a SN prototype consisting of a base station and sensor nodes. Sun Small Programmable Object Technology is used as a hardware basis for this work. The software has been developed in Java programming language including the host and sensor nodes\u27 applications. The conducted experiments have confirmed the higher level of design flexibility and optimization of the following criteria: energy consumption, QoD and QoS

Implementing Session Centered Calculi

Recently, specific attention has been devoted to the development of service oriented process calculi. Besides the foundational aspects, it is also interesting to have prototype implementations for them in order to assess usability and to minimize the gap between theory and practice. Typically, these implementations are done in Java taking advantage of its mechanisms supporting network applications. However, most of the recurrent features of service oriented applications are re-implemented from scratch. In this paper we show how to implement a service oriented calculus, CaSPiS (Calculus of Services with Pipelines and Sessions) using the Java framework IMC, where recurrent mechanisms for network applications are already provided. By using the session oriented and pattern matching communication mechanisms provided by IMC, it is relatively simple to implement in Java all CaSPiS abstractions and thus to easily write the implementation in Java of a CaSPiS process

On Secure Workflow Decentralisation on the Internet

Decentralised workflow management systems are a new research area, where most work to-date has focused on the system's overall architecture. As little attention has been given to the security aspects in such systems, we follow a security driven approach, and consider, from the perspective of available security building blocks, how security can be implemented and what new opportunities are presented when empowering the decentralised environment with modern distributed security protocols. Our research is motivated by a more general question of how to combine the positive enablers that email exchange enjoys, with the general benefits of workflow systems, and more specifically with the benefits that can be introduced in a decentralised environment. This aims to equip email users with a set of tools to manage the semantics of a message exchange, contents, participants and their roles in the exchange in an environment that provides inherent assurances of security and privacy. This work is based on a survey of contemporary distributed security protocols, and considers how these protocols could be used in implementing a distributed workflow management system with decentralised control . We review a set of these protocols, focusing on the required message sequences in reviewing the protocols, and discuss how these security protocols provide the foundations for implementing core control-flow, data, and resource patterns in a distributed workflow environment

Filtering Network Traffic Based on Protocol Encapsulation Rules

Packet filtering is a technology at the foundation of many traffic analysis tasks. While languages and tools for packet filtering have been available for many years, none of them supports filters operating on the encapsulation relationships found in each packet. This represents a problem as the number of possible encapsulations used to transport traffic is steadily increasing and we cannot define exactly which packets have to be captured. This paper presents our early work on an algorithm that models protocol filtering patterns (including encapsulation constraints) as Finite State Automata and supports the composition of multiple expressions within the same filter. The resulting, optimized filter is then translated into executable code. The above filtering algorithms are available in the NetBee open source library, which provides some basic tools for handling network packets (e.g., a tcpdump-like program) and APIs to build more advanced tool

VoIP: Making Secure Calls and Maintaining High Call Quality

Modern multimedia communication tools must have high security, high availability and high quality of service (QoS). Any security implementation will directly impact on QoS. This paper will investigate how end-to-end security impacts on QoS in Voice over Internet Protocol (VoIP). The QoS is measured in terms of lost packet ratio, latency and jitter using different encryption algorithms, no security and just the use of IP firewalls in Local and Wide Area Networks (LAN and WAN). The results of laboratory tests indicate that the impact on the overall performance of VoIP depends upon the bandwidth availability and encryption algorithm used. The implementation of any encryption algorithm in low bandwidth environments degrades the voice quality due to increased loss packets and packet latency, but as bandwidth increases encrypted VoIP calls provided better service compared to an unsecured environment.Les eines modernes de comunicació multimèdia han de tenir alta seguretat, alta disponibilitat i alta qualitat de servei (QoS). Cap tipus d¿implementació de seguretat tindrà un impacte directe en la qualitat de servei. En aquest article s¿investiga com la seguretat d'extrem a extrem impacta en la qualitat de servei de veu sobre el Protocol d'Internet (VoIP). La qualitat de servei es mesura en termes de pèrdua de proporció de paquets, latència i jitter utilitzant diferents algoritmes d¿encriptació, sense seguretat i només amb l'ús de tallafocs IP en local i en xarxes d'àrea àmplia (LAN i WAN). Els resultats de les proves de laboratori indiquen que l'impacte general sobre el rendiment de VoIP depèn de la disponibilitat d'ample de banda i l'algorisme de xifrat que s'utilitza. La implementació de qualsevol algorisme de xifrat en entorns de baix ample de banda degrada la veu a causa de l'augment de la pèrdua de paquets i latència dels paquets de qualitat, però quan l'ample de banda augmenta les trucades de VoIP xifrades proporcionen un millor servei en comparació amb un entorn sense seguretat.Las herramientas modernas de comunicación multimedia deben tener alta seguridad, alta disponibilidad y alta calidad de servicio (QoS). Ningún tipo de implementación de seguridad tendrá un impacto directo en la calidad de servicio. En este artículo se investiga como la seguridad de extremo a extremo impacta en la calidad de servicio de voz sobre el Protocolo de Internet (VoIP). La calidad de servicio se mide en términos de pérdida de proporción de paquetes, latencia y jitter utilizando diferentes algoritmos de encriptación, sin seguridad y sólo con el uso de cortafuegos IP en local y en redes de área amplia (LAN y WAN). Los resultados de las pruebas de laboratorio indican que el impacto general sobre el rendimiento de VoIP depende de la disponibilidad de ancho de banda y el algoritmo de cifrado que se utiliza. La implementación de cualquier algoritmo de cifrado en entornos de bajo ancho de banda degrada la voz debido al aumento de la pérdida de paquetes y latencia de los paquetes de calidad, pero cuando el ancho de banda aumenta las llamadas de VoIP cifradas proporcionan un mejor servicio en comparación con un entorno sin seguridad