2,667 research outputs found
Changes in MEG resting-state networks are related to cognitive decline in type 1 diabetes mellitus patients
OBJECTIVE: Integrity of resting-state functional brain networks (RSNs) is important for proper cognitive functioning. In type 1 diabetes mellitus (T1DM) cognitive decrements are commonly observed, possibly due to alterations in RSNs, which may vary according to microvascular complication status. Thus, we tested the hypothesis that functional connectivity in RSNs differs according to clinical status and correlates with cognition in T1DM patients, using an unbiased approach with high spatio-temporal resolution functional network.; METHODS: Resting-state magnetoencephalographic (MEG) data for T1DM patients with (n=42) and without (n=41) microvascular complications and 33 healthy participants were recorded. MEG time-series at source level were reconstructed using a recently developed atlas-based beamformer. Functional connectivity within classical frequency bands, estimated by the phase lag index (PLI), was calculated within eight commonly found RSNs. Neuropsychological tests were used to assess cognitive performance, and the relation with RSNs was evaluated.; RESULTS: Significant differences in terms of RSN functional connectivity between the three groups were observed in the lower alpha band, in the default-mode (DMN), executive control (ECN) and sensorimotor (SMN) RSNs. T1DM patients with microvascular complications showed the weakest functional connectivity in these networks relative to the other groups. For DMN, functional connectivity was higher in patients without microangiopathy relative to controls (all p<0.05). General cognitive performance for both patient groups was worse compared with healthy controls. Lower DMN alpha band functional connectivity correlated with poorer general cognitive ability in patients with microvascular complications.; DISCUSSION: Altered RSN functional connectivity was found in T1DM patients depending on clinical status. Lower DMN functional connectivity was related to poorer cognitive functioning. These results indicate that functional connectivity may play a key role in T1DM-related cognitive dysfunction
Complexity Analysis of Spontaneous Brain Activity in Attention-Deficit/Hyperactivity Disorder: Diagnostic Implications
Background: Attention-deficit/hyperactivity disorder (ADHD) is defined as the most common neurobehavioral disorder of childhood, but an objective diagnostic test is not available yet to date. Neurophychological, neuroimaging, and neurophysiological research offer ample evidence of brain and behavioral dysfunctions in ADHD, but these findings have not been useful as a diagnostic test. Methods: Whole-head magnetoencephalographic recordings were obtained from 14 diagnosed ADHD patients and 14 healthy children during resting conditions. Lempel-Ziv complexity (LZC) values were obtained for each channel and child and averaged in five sensor groups: anterior, central, left lateral, right lateral, and posterior. Results: Lempel-Ziv complexity scores were significantly higher in control subjects, with the maximum value in anterior region. Combining age and anterior complexity values allowed the correct classification of ADHD patients and control subjects with a 93% sensitivity and 79% specificity. Control subjects showed an age-related monotonic increase of LZC scores in all sensor groups, while children with ADHD exhibited a nonsignificant tendency toward decreased LZC scores. The age-related divergence resulted in a 100% specificity in children older than 9 years. Conclusions: Results support the role of a frontal hypoactivity in the diagnosis of ADHD. Moreover, the age-related divergence of complexity scores between ADHD patients and control subjects might reflect distinctive developmental trajectories. This interpretation of our results is in agreement with recent investigations reporting a delay of cortical maturation in the prefrontal corte
Detecting single-trial EEG evoked potential using a wavelet domain linear mixed model: application to error potentials classification
Objective. The main goal of this work is to develop a model for multi-sensor
signals such as MEG or EEG signals, that accounts for the inter-trial
variability, suitable for corresponding binary classification problems. An
important constraint is that the model be simple enough to handle small size
and unbalanced datasets, as often encountered in BCI type experiments.
Approach. The method involves linear mixed effects statistical model, wavelet
transform and spatial filtering, and aims at the characterization of localized
discriminant features in multi-sensor signals. After discrete wavelet transform
and spatial filtering, a projection onto the relevant wavelet and spatial
channels subspaces is used for dimension reduction. The projected signals are
then decomposed as the sum of a signal of interest (i.e. discriminant) and
background noise, using a very simple Gaussian linear mixed model. Main
results. Thanks to the simplicity of the model, the corresponding parameter
estimation problem is simplified. Robust estimates of class-covariance matrices
are obtained from small sample sizes and an effective Bayes plug-in classifier
is derived. The approach is applied to the detection of error potentials in
multichannel EEG data, in a very unbalanced situation (detection of rare
events). Classification results prove the relevance of the proposed approach in
such a context. Significance. The combination of linear mixed model, wavelet
transform and spatial filtering for EEG classification is, to the best of our
knowledge, an original approach, which is proven to be effective. This paper
improves on earlier results on similar problems, and the three main ingredients
all play an important role
Loss of brain inter-frequency hubs in Alzheimer's disease
Alzheimer's disease (AD) causes alterations of brain network structure and
function. The latter consists of connectivity changes between oscillatory
processes at different frequency channels. We proposed a multi-layer network
approach to analyze multiple-frequency brain networks inferred from
magnetoencephalographic recordings during resting-states in AD subjects and
age-matched controls. Main results showed that brain networks tend to
facilitate information propagation across different frequencies, as measured by
the multi-participation coefficient (MPC). However, regional connectivity in AD
subjects was abnormally distributed across frequency bands as compared to
controls, causing significant decreases of MPC. This effect was mainly
localized in association areas and in the cingulate cortex, which acted, in the
healthy group, as a true inter-frequency hub. MPC values significantly
correlated with memory impairment of AD subjects, as measured by the total
recall score. Most predictive regions belonged to components of the
default-mode network that are typically affected by atrophy, metabolism
disruption and amyloid-beta deposition. We evaluated the diagnostic power of
the MPC and we showed that it led to increased classification accuracy (78.39%)
and sensitivity (91.11%). These findings shed new light on the brain functional
alterations underlying AD and provide analytical tools for identifying
multi-frequency neural mechanisms of brain diseases.Comment: 27 pages, 6 figures, 3 tables, 3 supplementary figure
Time-Contrastive Learning Based Deep Bottleneck Features for Text-Dependent Speaker Verification
There are a number of studies about extraction of bottleneck (BN) features
from deep neural networks (DNNs)trained to discriminate speakers, pass-phrases
and triphone states for improving the performance of text-dependent speaker
verification (TD-SV). However, a moderate success has been achieved. A recent
study [1] presented a time contrastive learning (TCL) concept to explore the
non-stationarity of brain signals for classification of brain states. Speech
signals have similar non-stationarity property, and TCL further has the
advantage of having no need for labeled data. We therefore present a TCL based
BN feature extraction method. The method uniformly partitions each speech
utterance in a training dataset into a predefined number of multi-frame
segments. Each segment in an utterance corresponds to one class, and class
labels are shared across utterances. DNNs are then trained to discriminate all
speech frames among the classes to exploit the temporal structure of speech. In
addition, we propose a segment-based unsupervised clustering algorithm to
re-assign class labels to the segments. TD-SV experiments were conducted on the
RedDots challenge database. The TCL-DNNs were trained using speech data of
fixed pass-phrases that were excluded from the TD-SV evaluation set, so the
learned features can be considered phrase-independent. We compare the
performance of the proposed TCL bottleneck (BN) feature with those of
short-time cepstral features and BN features extracted from DNNs discriminating
speakers, pass-phrases, speaker+pass-phrase, as well as monophones whose labels
and boundaries are generated by three different automatic speech recognition
(ASR) systems. Experimental results show that the proposed TCL-BN outperforms
cepstral features and speaker+pass-phrase discriminant BN features, and its
performance is on par with those of ASR derived BN features. Moreover,....Comment: Copyright (c) 2019 IEEE. Personal use of this material is permitted.
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Integrating EEG and MEG signals to improve motor imagery classification in brain-computer interfaces
We propose a fusion approach that combines features from simultaneously
recorded electroencephalographic (EEG) and magnetoencephalographic (MEG)
signals to improve classification performances in motor imagery-based
brain-computer interfaces (BCIs). We applied our approach to a group of 15
healthy subjects and found a significant classification performance enhancement
as compared to standard single-modality approaches in the alpha and beta bands.
Taken together, our findings demonstrate the advantage of considering
multimodal approaches as complementary tools for improving the impact of
non-invasive BCIs
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