1,489 research outputs found
Level-Set Based Artery-Vein Separation in Blood Pool Agent CE-MR Angiograms
Blood pool agents (BPAs) for contrast-enhanced (CE) magnetic-resonance angiography (MRA) allow prolonged imaging times for higher contrast and resolution. Imaging is performed during the steady state when the contrast agent is distributed through the complete vascular system. However, simultaneous venous and arterial enhancement in this steady state hampers interpretation. In order to improve visualization of the arteries and veins from steady-state BPA data, a semiautomated method for artery-vein separation is presented. In this method, the central arterial axis and central venous axis are used as initializations for two surfaces that simultaneously evolve in order to capture the arterial and venous parts of the vasculature using the level-set framework. Since arteries and veins can be in close proximity of each other, leakage from the evolving arterial (venous) surface into the venous (arterial) part of the vasculature is inevitable. In these situations, voxels are labeled arterial or venous based on the arrival time of the respective surface. The evolution is steered by external forces related to feature images derived from the image data and by internal forces related to the geometry of the level sets. In this paper, the robustness and accuracy of three external forces (based on image intensity, image gradient, and vessel-enhancement filtering) and combinations of them are investigated and tested on seven patient datasets. To this end, results with the level-set-based segmentation are compared to the reference-standard manually obtained segmentations. Best results are achieved by applying a combination of intensity- and gradient-based forces and a smoothness constraint based on the curvature of the surface. By applying this combination to the seven datasets, it is shown that, with minimal user interaction, artery-vein separation for improved arterial and venous visualization in BPA CE-MRA can be achieved
YoloCurvSeg: You Only Label One Noisy Skeleton for Vessel-style Curvilinear Structure Segmentation
Weakly-supervised learning (WSL) has been proposed to alleviate the conflict
between data annotation cost and model performance through employing
sparsely-grained (i.e., point-, box-, scribble-wise) supervision and has shown
promising performance, particularly in the image segmentation field. However,
it is still a very challenging problem due to the limited supervision,
especially when only a small number of labeled samples are available.
Additionally, almost all existing WSL segmentation methods are designed for
star-convex structures which are very different from curvilinear structures
such as vessels and nerves. In this paper, we propose a novel sparsely
annotated segmentation framework for curvilinear structures, named YoloCurvSeg,
based on image synthesis. A background generator delivers image backgrounds
that closely match real distributions through inpainting dilated skeletons. The
extracted backgrounds are then combined with randomly emulated curves generated
by a Space Colonization Algorithm-based foreground generator and through a
multilayer patch-wise contrastive learning synthesizer. In this way, a
synthetic dataset with both images and curve segmentation labels is obtained,
at the cost of only one or a few noisy skeleton annotations. Finally, a
segmenter is trained with the generated dataset and possibly an unlabeled
dataset. The proposed YoloCurvSeg is evaluated on four publicly available
datasets (OCTA500, CORN, DRIVE and CHASEDB1) and the results show that
YoloCurvSeg outperforms state-of-the-art WSL segmentation methods by large
margins. With only one noisy skeleton annotation (respectively 0.14%, 0.03%,
1.40%, and 0.65% of the full annotation), YoloCurvSeg achieves more than 97% of
the fully-supervised performance on each dataset. Code and datasets will be
released at https://github.com/llmir/YoloCurvSeg.Comment: 11 pages, 10 figures, submitted to IEEE Transactions on Medical
Imaging (TMI
Vessel enhancing diffusion: a scale space representation of vessel
A method is proposed to enhance vascular structures within the framework
of scale space theory. We combine a smooth vessel filter which is based on
a geometrical analysis of the Hessian's eigensystem, with a non-linear
anisotropic diffusion scheme. The amount and orientation of diffusion
depend on the local vessel likeliness. Vessel enhancing diffusion (VED) is
applied to patient and phantom data and compared to linear, regularized
Perona-Malik, edge and coherence enhancing diffusion. The method performs
better than most of the existing techniques in visualizing vessels with
varying radii and in enhancing vessel appearance. A diameter study on
phantom data shows that VED least affects the accuracy of diameter
measurements. It is shown that using VED as a preprocessing step improves
level set based segmentation of the cerebral vasculature, in particular
segmentation of the smaller vessels of the vasculature
Vessel tractography using an intensity based tensor model with branch detection
In this paper, we present a tubular structure seg- mentation method that utilizes a second order tensor constructed from directional intensity measurements, which is inspired from diffusion tensor image (DTI) modeling. The constructed anisotropic tensor which is fit inside a vessel drives the segmen- tation analogously to a tractography approach in DTI. Our model is initialized at a single seed point and is capable of capturing whole vessel trees by an automatic branch detection algorithm developed in the same framework. The centerline of the vessel as well as its thickness is extracted. Performance results within the Rotterdam Coronary Artery Algorithm Evaluation framework are provided for comparison with existing techniques. 96.4% average overlap with ground truth delineated by experts is obtained in addition to other measures reported in the paper. Moreover, we demonstrate further quantitative results over synthetic vascular datasets, and we provide quantitative experiments for branch detection on patient Computed Tomography Angiography (CTA) volumes, as well as qualitative evaluations on the same CTA datasets, from visual scores by a cardiologist expert
Direction-adaptive grey-level morphology. Application to 3D vascular brain imaging
International audienceSegmentation and analysis of blood vessels is an important issue in medical imaging. In 3D cerebral angiographic data, the vascular signal is however hard to accurately detect and can, in particular, be disconnected. In this article, we present a procedure utilising both linear, Hessian-based and morphological methods for blood vessel edge enhancement and reconnection. More specifically, multi-scale second-order derivative analysis is performed to detect candidate vessels as well as their orientation. This information is then fed to a spatially-variant morphological filter for reconnection and reconstruction. The result is a fast and effective vessel-reconnecting method
Curvilinear Structure Enhancement in Biomedical Images
Curvilinear structures can appear in many different areas and at a variety of scales. They can be axons and dendrites in the brain, blood vessels in the fundus, streets, rivers or fractures in buildings, and others. So, it is essential to study curvilinear structures in many fields such as neuroscience, biology, and cartography regarding image processing.
Image processing is an important field for the help to aid in biomedical imaging especially the diagnosing the disease. Image enhancement is the early step of image analysis.
In this thesis, I focus on the research, development, implementation, and validation of 2D and 3D curvilinear structure enhancement methods, recently established. The proposed methods are based on phase congruency, mathematical morphology, and tensor representation concepts.
First, I have introduced a 3D contrast independent phase congruency-based enhancement approach. The obtained results demonstrate the proposed approach is robust against the contrast variations in 3D biomedical images.
Second, I have proposed a new mathematical morphology-based approach called the bowler-hat transform. In this approach, I have combined the mathematical morphology with a local tensor representation of curvilinear structures in images.
The bowler-hat transform is shown to give better results than comparison methods on challenging data such as retinal/fundus images. The bowler-hat transform is shown to give better results than comparison methods on challenging data such as retinal/fundus images. Especially the proposed method is quite successful while enhancing of curvilinear structures at junctions.
Finally, I have extended the bowler-hat approach to the 3D version to prove the applicability, reliability, and ability of it in 3D
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