FPGA acceleration of sequence analysis tools in bioinformatics

Thesis (Ph.D.)--Boston UniversityWith advances in biotechnology and computing power, biological data are being produced at an exceptional rate. The purpose of this study is to analyze the application of FPGAs to accelerate high impact production biosequence analysis tools. Compared with other alternatives, FPGAs offer huge compute power, lower power consumption, and reasonable flexibility. BLAST has become the de facto standard in bioinformatic approximate string matching and so its acceleration is of fundamental importance. It is a complex highly-optimized system, consisting of tens of thousands of lines of code and a large number of heuristics. Our idea is to emulate the main phases of its algorithm on FPGA. Utilizing our FPGA engine, we quickly reduce the size of the database to a small fraction, and then use the original code to process the query. Using a standard FPGA-based system, we achieved 12x speedup over a highly optimized multithread reference code. Multiple Sequence Alignment (MSA)--the extension of pairwise Sequence Alignment to multiple Sequences--is critical to solve many biological problems. Previous attempts to accelerate Clustal-W, the most commonly used MSA code, have directly mapped a portion of the code to the FPGA. We use a new approach: we apply prefiltering of the kind commonly used in BLAST to perform the initial all-pairs alignments. This results in a speedup of from 8Ox to 190x over the CPU code (8 cores). The quality is comparable to the original according to a commonly used benchmark suite evaluated with respect to multiple distance metrics. The challenge in FPGA-based acceleration is finding a suitable application mapping. Unfortunately many software heuristics do not fall into this category and so other methods must be applied. One is restructuring: an entirely new algorithm is applied. Another is to analyze application utilization and develop accuracy/performance tradeoffs. Using our prefiltering approach and novel FPGA programming models we have achieved significant speedup over reference programs. We have applied approximation, seeding, and filtering to this end. The bulk of this study is to introduce the pros and cons of these acceleration models for biosequence analysis tools

Bioinformatics

This book is divided into different research areas relevant in Bioinformatics such as biological networks, next generation sequencing, high performance computing, molecular modeling, structural bioinformatics, molecular modeling and intelligent data analysis. Each book section introduces the basic concepts and then explains its application to problems of great relevance, so both novice and expert readers can benefit from the information and research works presented here

Investigation of Parallel Data Processing Using Hybrid High Performance CPU + GPU Systems and CUDA Streams

The paper investigates parallel data processing in a hybrid CPU+GPU(s) system using multiple CUDA streams for overlapping communication and computations. This is crucial for efficient processing of data, in particular incoming data stream processing that would naturally be forwarded using multiple CUDA streams to GPUs. Performance is evaluated for various compute time to host-device communication time ratios, numbers of CUDA streams, for various numbers of threads managing computations on GPUs. Tests also reveal benefits of using CUDA MPS for overlapping communication and computations when using multiple processes. Furthermore, using standard memory allocation on a GPU and Unified Memory versions are compared, the latter including programmer added prefetching. Performance of a hybrid CPU+GPU version as well as scaling across multiple GPUs are demonstrated showing good speed-ups of the approach. Finally, the performance per power consumption of selected configurations are presented for various numbers of streams and various relative performances of GPUs and CPUs

Advanced photonic and electronic systems - WILGA 2017

WILGA annual symposium on advanced photonic and electronic systems has been organized by young scientist for young scientists since two decades. It traditionally gathers more than 350 young researchers and their tutors. Ph.D students and graduates present their recent achievements during well attended oral sessions. Wilga is a very good digest of Ph.D. works carried out at technical universities in electronics and photonics, as well as information sciences throughout Poland and some neighboring countries. Publishing patronage over Wilga keep Elektronika technical journal by SEP, IJET by PAN and Proceedings of SPIE. The latter world editorial series publishes annually more than 200 papers from Wilga. Wilga 2017 was the XL edition of this meeting. The following topical tracks were distinguished: photonics, electronics, information technologies and system research. The article is a digest of some chosen works presented during Wilga 2017 symposium. WILGA 2017 works were published in Proc. SPIE vol.10445

Analytical cost metrics: days of future past

2019 Summer.Includes bibliographical references.Future exascale high-performance computing (HPC) systems are expected to be increasingly heterogeneous, consisting of several multi-core CPUs and a large number of accelerators, special-purpose hardware that will increase the computing power of the system in a very energy-efficient way. Specialized, energy-efficient accelerators are also an important component in many diverse systems beyond HPC: gaming machines, general purpose workstations, tablets, phones and other media devices. With Moore's law driving the evolution of hardware platforms towards exascale, the dominant performance metric (time efficiency) has now expanded to also incorporate power/energy efficiency. This work builds analytical cost models for cost metrics such as time, energy, memory access, and silicon area. These models are used to predict the performance of applications, for performance tuning, and chip design. The idea is to work with domain specific accelerators where analytical cost models can be accurately used for performance optimization. The performance optimization problems are formulated as mathematical optimization problems. This work explores the analytical cost modeling and mathematical optimization approach in a few ways. For stencil applications and GPU architectures, the analytical cost models are developed for execution time as well as energy. The models are used for performance tuning over existing architectures, and are coupled with silicon area models of GPU architectures to generate highly efficient architecture configurations. For matrix chain products, analytical closed form solutions for off-chip data movement are built and used to minimize the total data movement cost of a minimum op count tree

Low-Impact Profiling of Streaming, Heterogeneous Applications

Computer engineers are continually faced with the task of translating improvements in fabrication process technology: i.e., Moore\u27s Law) into architectures that allow computer scientists to accelerate application performance. As feature-size continues to shrink, architects of commodity processors are designing increasingly more cores on a chip. While additional cores can operate independently with some tasks: e.g. the OS and user tasks), many applications see little to no improvement from adding more processor cores alone. For many applications, heterogeneous systems offer a path toward higher performance. Significant performance and power gains have been realized by combining specialized processors: e.g., Field-Programmable Gate Arrays, Graphics Processing Units) with general purpose multi-core processors. Heterogeneous applications need to be programmed differently than traditional software. One approach, stream processing, fits these systems particularly well because of the segmented memories and explicit expression of parallelism. Unfortunately, debugging and performance tools that support streaming, heterogeneous applications do not exist. This dissertation presents TimeTrial, a performance measurement system that enables performance optimization of streaming applications by profiling the application deployed on a heterogeneous system. TimeTrial performs low-impact measurements by dedicating computing resources to monitoring and by aggressively compressing performance traces into statistical summaries guided by user specification of the performance queries of interest