Immune Inspired Cooperative Mechanism with Refined Low-level Behaviors for Multi-Robot Shepherding

In this paper, immune systems and its relationships with multi-robot shepherding problems are discussed. The proposed algorithm is based on immune network theories that have many similarities with the multi-robot systems domain. The underlying immune inspired cooperative mechanism of the algorithm is simulated and evaluated. The paper also describes a refinement of the memory-based immune network that enhances a robot’s action-selection process. A refined model, which is based on the Immune Network T-cell-regulated—with Memory (INT-M) model, is applied to the dog-sheep scenario. The refinements involves the low-level behaviors of the robot dogs, namely shepherds’ formation and shepherds’ approach. These behaviors would make the shepherds to form a line behind the group of sheep and also obey a safety zone of each flock, thus achieving better control of the flock and minimize flock separation occurrences. Simulation experiments are conducted on the Player/Stage robotics platform

Multi-layered model of individual HIV infection progression and mechanisms of phenotypical expression

Cite as: Perrin, Dimitri (2008) Multi-layered model of individual HIV infection progression and mechanisms of phenotypical expression. PhD thesis, Dublin City University

DATA DRIVEN INTELLIGENT AGENT NETWORKS FOR ADAPTIVE MONITORING AND CONTROL

To analyze the characteristics and predict the dynamic behaviors of complex systems over time, comprehensive research to enable the development of systems that can intelligently adapt to the evolving conditions and infer new knowledge with algorithms that are not predesigned is crucially needed. This dissertation research studies the integration of the techniques and methodologies resulted from the fields of pattern recognition, intelligent agents, artificial immune systems, and distributed computing platforms, to create technologies that can more accurately describe and control the dynamics of real-world complex systems. The need for such technologies is emerging in manufacturing, transportation, hazard mitigation, weather and climate prediction, homeland security, and emergency response. Motivated by the ability of mobile agents to dynamically incorporate additional computational and control algorithms into executing applications, mobile agent technology is employed in this research for the adaptive sensing and monitoring in a wireless sensor network. Mobile agents are software components that can travel from one computing platform to another in a network and carry programs and data states that are needed for performing the assigned tasks. To support the generation, migration, communication, and management of mobile monitoring agents, an embeddable mobile agent system (Mobile-C) is integrated with sensor nodes. Mobile monitoring agents visit distributed sensor nodes, read real-time sensor data, and perform anomaly detection using the equipped pattern recognition algorithms. The optimal control of agents is achieved by mimicking the adaptive immune response and the application of multi-objective optimization algorithms. The mobile agent approach provides potential to reduce the communication load and energy consumption in monitoring networks. The major research work of this dissertation project includes: (1) studying effective feature extraction methods for time series measurement data; (2) investigating the impact of the feature extraction methods and dissimilarity measures on the performance of pattern recognition; (3) researching the effects of environmental factors on the performance of pattern recognition; (4) integrating an embeddable mobile agent system with wireless sensor nodes; (5) optimizing agent generation and distribution using artificial immune system concept and multi-objective algorithms; (6) applying mobile agent technology and pattern recognition algorithms for adaptive structural health monitoring and driving cycle pattern recognition; (7) developing a web-based monitoring network to enable the visualization and analysis of real-time sensor data remotely. Techniques and algorithms developed in this dissertation project will contribute to research advances in networked distributed systems operating under changing environments

Complete haplotype phasing of the MHC and KIR loci with targeted HaploSeq

BackgroundThe MHC and KIR loci are clinically relevant regions of the genome. Typing the sequence of these loci has a wide range of applications including organ transplantation, drug discovery, pharmacogenomics and furthering fundamental research in immune genetics. Rapid advances in biochemical and next-generation sequencing (NGS) technologies have enabled several strategies for precise genotyping and phasing of candidate HLA alleles. Nonetheless, as typing of candidate HLA alleles alone reveals limited aspects of the genetics of MHC region, it is insufficient for the comprehensive utility of the aforementioned applications. For this reason, we believe phasing the entire MHC and KIR locus onto a single locus-spanning haplotype can be a critical improvement for better understanding transplantation biology.ResultsGenerating long-range (>1 Mb) phase information is traditionally very challenging. As proximity-ligation based methods of DNA sequencing preserves chromosome-span phase information, we have utilized this principle to demonstrate its utility towards generating full-length phasing of MHC and KIR loci in human samples. We accurately (~99%) reconstruct the complete haplotypes for over 90% of sequence variants (coding and non-coding) within these two loci that collectively span 4-megabases.ConclusionsBy haplotyping a majority of coding and non-coding alleles at the MHC and KIR loci in a single assay, this method has the potential to assist transplantation matching and facilitate investigation of the genetic basis of human immunity and disease

Nanovectors Design for Theranostic Applications in Colorectal Cancer

Colorectal cancer (CRC) is a diffused disease with limited therapeutic options, none of which are often curative. Based on the molecular markers and targets expressed by the affected tissues, numerous novel approaches have been developed to study and treat this disease. In particular, the field of nanotechnology offers an astonishingly wide array of innovative nanovectors with high versatility and adaptability for both diagnosis and therapy (the so called \u201ctheranostic platforms\u201d). However, such complexity can make the selection of a specific nanocarrier model to study a perplexing endeavour for the biomedical scientist or clinician not familiar with this field of inquiry. This review offers a comprehensive overview of this wide body of knowledge, in order to outline the essential requirements for the clinical viability evaluation of a nanovector model in CRC. In particular, the differences among the foremost designs, their specific advantages, and technological caveats will be treated, never forgetting the ultimate endpoint for these systems development: the clinical practice

Development and evaluation of a fault detection and identification scheme for the WVU YF-22 UAV using the artificial immune system approach

A failure detection and identification (FDI) scheme is developed for a small remotely controlled jet aircraft based on the Artificial Immune System (AIS) paradigm. Pilot-in-the-loop flight data are used to develop and test a scheme capable of identifying known and unknown aircraft actuator and sensor failures. Negative selection is used as the main mechanism for self/non-self definition; however, an alternative approach using positive selection to enhance performance is also presented. Tested failures include aileron and stabilator locked at trim and angular rate sensor bias. Hyper-spheres are chosen to represent detectors. Different definitions of distance for the matching rules are applied and their effect on the behavior of hyper-bodies is discussed. All the steps involved in the creation of the scheme are presented including design selections embedded in the different algorithms applied to generate the detectors set. The evaluation of the scheme is performed in terms of detection rate, false alarms, and detection time for normal conditions and upset conditions. The proposed detection scheme achieves good detection performance for all flight conditions considered. This approach proves promising potential to cope with the multidimensional characteristics of integrated/comprehensive detection for aircraft sub-system failures.;A preliminary performance comparison between an AIS based FDI scheme and a Neural Network and Floating Threshold based one is presented including groundwork on assessing possible improvements on pilot situational awareness aided by FDI schemes. Initial results favor the AIS approach to FDI due to its rather undemanding adaptation capabilities to new environments. The presence of the FDI scheme suggests benefits for the interaction between the pilot and the upset conditions by improving the accuracy of the identification of each particular failure and decreasing the detection delays

Immune System Based Control and Intelligent Agent Design for Power System Applications

The National Academy of Engineering has selected the US Electric Power Grid as the supreme engineering achievement of the 20th century. Yet, this same grid is struggling to keep up with the increasing demand for electricity, its quality and cost. A growing recognition of the need to modernize the grid to meet future challenges has found articulation in the vision of a Smart Grid in using new control strategies that are intelligent, distributed, and adaptive. The objective of this work is to develop smart control systems inspired from the biological Human Immune System to better manage the power grid at the both generation and distribution levels. The work is divided into three main sections. In the first section, we addressed the problem of Automatic Generation Control design. The Clonal Selection theory is successfully applied as an optimization technique to obtain decentralized control gains that minimize a performance index based on Area Control Errors. Then the Immune Network theory is used to design adaptive controllers in order to diminish the excess maneuvering of the units and help the control areas comply with the North American Electric Reliability Corporation\u27s standards set to insure good quality of service and equitable mutual assistance by the interconnected energy balancing areas. The second section of this work addresses the design and deployment of Multi Agent Systems on both terrestrial and shipboard power systems self-healing using a novel approach based on the Immune Multi-Agent System (IMAS). The Immune System is viewed as a highly organized and distributed Multi-Cell System that strives to heal the body by working together and communicating to get rid of the pathogens. In this work both simulation and hardware design and deployment of the MAS are addressed. The third section of this work consists in developing a small scale smart circuit by modifying and upgrading the existing Analog Power Simulator to demonstrate the effectiveness of the developed technologies. We showed how to develop smart Agents hardware along with a wireless communication platform and the electronic switches. After putting together the different designed pieces, the resulting Multi Agent System is integrated into the Power Simulator Hardware. The multi Agent System developed is tested for fault isolation, reconfiguration, and restoration problems by simulating a permanent three phase fault on one of the feeder lines. The experimental results show that the Multi Agent System hardware developed performed effectively and in a timely manner which confirms that this technology is very promising and a very good candidate for Smart Grid control applications

BIOLOGICAL INSPIRED INTRUSION PREVENTION AND SELF-HEALING SYSTEM FOR CRITICAL SERVICES NETWORK

With the explosive development of the critical services network systems and Internet, the need for networks security systems have become even critical with the enlargement of information technology in everyday life. Intrusion Prevention System (IPS) provides an in-line mechanism focus on identifying and blocking malicious network activity in real time. This thesis presents new intrusion prevention and self-healing system (SH) for critical services network security. The design features of the proposed system are inspired by the human immune system, integrated with pattern recognition nonlinear classification algorithm and machine learning. Firstly, the current intrusions preventions systems, biological innate and adaptive immune systems, autonomic computing and self-healing mechanisms are studied and analyzed. The importance of intrusion prevention system recommends that artificial immune systems (AIS) should incorporate abstraction models from innate, adaptive immune system, pattern recognition, machine learning and self-healing mechanisms to present autonomous IPS system with fast and high accurate detection and prevention performance and survivability for critical services network system. Secondly, specification language, system design, mathematical and computational models for IPS and SH system are established, which are based upon nonlinear classification, prevention predictability trust, analysis, self-adaptation and self-healing algorithms. Finally, the validation of the system carried out by simulation tests, measuring, benchmarking and comparative studies. New benchmarking metrics for detection capabilities, prevention predictability trust and self-healing reliability are introduced as contributions for the IPS and SH system measuring and validation. Using the software system, design theories, AIS features, new nonlinear classification algorithm, and self-healing system show how the use of presented systems can ensure safety for critical services networks and heal the damage caused by intrusion. This autonomous system improves the performance of the current intrusion prevention system and carries on system continuity by using self-healing mechanism