14,876 research outputs found

    Exploring narrativity in data visualization in journalism

    Get PDF
    Many news stories are based on data visualization, and storytelling with data has become a buzzword in journalism. But what exactly does storytelling with data mean? When does a data visualization tell a story? And what are narrative constituents in data visualization? This chapter first defines the key terms in this context: story, narrative, narrativity, showing and telling. Then, it sheds light on the various forms of narrativity in data visualization and, based on a corpus analysis of 73 data visualizations, describes the basic visual elements that constitute narrativity: the instance of a narrator, sequentiality, temporal dimension, and tellability. The paper concludes that understanding how data are transformed into visual stories is key to understanding how facts are shaped and communicated in society

    From the Book Page to the Big Screen: An Exploration of Literature-to-Film Adaptions and Their Use in the Classroom

    Get PDF
    Many classic titles of children’s literature have been adapted into feature film presentations. Although often regarded as a mere form of entertainment, movies can and should be incorporated into the elementary classroom as supplementary material to be paired with their corresponding works of literature. The four examples provided include Cloudy with a Chance of Meatballs by Judi Barrett, A Wrinkle in Time by Madeleine L’Engle, The Giver by Lois Lowry, and Peter Pan by J. M. Barrie. Each of these four works originated as a book that was later recreated into a film format with varying degrees of accuracy to the original story. Through a close examination of the author, theme, classroom application, and film connection, a greater appreciation is gained for the integration of film in the language arts classroom

    Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

    Get PDF
    Activation of heterotrimeric G proteins is a key step in many signaling cascades. However, a complete mechanism for this process, which requires allosteric communication between binding sites that are ~30 Å apart, remains elusive. We construct an atomically detailed model of G protein activation by combining three powerful computational methods: metadynamics, Markov state models (MSMs), and CARDS analysis of correlated motions. We uncover a mechanism that is consistent with a wide variety of structural and biochemical data. Surprisingly, the rate-limiting step for GDP release correlates with tilting rather than translation of the GPCR-binding helix 5. β-Strands 1 - 3 and helix 1 emerge as hubs in the allosteric network that links conformational changes in the GPCR-binding site to disordering of the distal nucleotide-binding site and consequent GDP release. Our approach and insights provide foundations for understanding disease-implicated G protein mutants, illuminating slow events in allosteric networks, and examining unbinding processes with slow off-rates

    UNLV Best Teaching Practices Expo 2019

    Full text link
    https://digitalscholarship.unlv.edu/btp_expo/1084/thumbnail.jp

    De novo design of a homo-trimeric amantadine-binding protein.

    Get PDF
    The computational design of a symmetric protein homo-oligomer that binds a symmetry-matched small molecule larger than a metal ion has not yet been achieved. We used de novo protein design to create a homo-trimeric protein that binds the C3 symmetric small molecule drug amantadine with each protein monomer making identical interactions with each face of the small molecule. Solution NMR data show that the protein has regular three-fold symmetry and undergoes localized structural changes upon ligand binding. A high-resolution X-ray structure reveals a close overall match to the design model with the exception of water molecules in the amantadine binding site not included in the Rosetta design calculations, and a neutron structure provides experimental validation of the computationally designed hydrogen-bond networks. Exploration of approaches to generate a small molecule inducible homo-trimerization system based on the design highlight challenges that must be overcome to computationally design such systems

    SciTech News Volume 71, No. 2 (2017)

    Get PDF
    Columns and Reports From the Editor 3 Division News Science-Technology Division 5 Chemistry Division 8 Engineering Division 9 Aerospace Section of the Engineering Division 12 Architecture, Building Engineering, Construction and Design Section of the Engineering Division 14 Reviews Sci-Tech Book News Reviews 16 Advertisements IEEE

    The Boston University Photonics Center annual report 2016-2017

    Full text link
    This repository item contains an annual report that summarizes activities of the Boston University Photonics Center in the 2016-2017 academic year. The report provides quantitative and descriptive information regarding photonics programs in education, interdisciplinary research, business innovation, and technology development. The Boston University Photonics Center (BUPC) is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light.This has undoubtedly been the Photonics Center’s best year since I became Director 10 years ago. In the following pages, you will see highlights of the Center’s activities in the past year, including more than 100 notable scholarly publications in the leading journals in our field, and the attraction of more than 22 million dollars in new research grants/contracts. Last year I had the honor to lead an international search for the first recipient of the Moustakas Endowed Professorship in Optics and Photonics, in collaboration with ECE Department Chair Clem Karl. This professorship honors the Center’s most impactful scholar and one of the Center’s founding visionaries, Professor Theodore Moustakas. We are delighted to haveawarded this professorship to Professor Ji-Xin Cheng, who joined our faculty this year.The past year also marked the launch of Boston University’s Neurophotonics Center, which will be allied closely with the Photonics Center. Leading that Center will be a distinguished new faculty member, Professor David Boas. David and I are together leading a new Neurophotonics NSF Research Traineeship Program that will provide $3M to promote graduate traineeships in this emerging new field. We had a busy summer hosting NSF Sites for Research Experiences for Undergraduates, Research Experiences for Teachers, and the BU Student Satellite Program. As a community, we emphasized the theme of “Optics of Cancer Imaging” at our annual symposium, hosted by Darren Roblyer. We entered a five-year second phase of NSF funding in our Industry/University Collaborative Research Center on Biophotonic Sensors and Systems, which has become the centerpiece of our translational biophotonics program. That I/UCRC continues to focus on advancing the health care and medical device industries
    • …
    corecore