441 research outputs found

    (b2023 to 2014) The UNBELIEVABLE similarities between the ideas of some people (2006-2016) and my ideas (2002-2008) in physics (quantum mechanics, cosmology), cognitive neuroscience, philosophy of mind, and philosophy (this manuscript would require a REVOLUTION in international academy environment!)

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    (b2023 to 2014) The UNBELIEVABLE similarities between the ideas of some people (2006-2016) and my ideas (2002-2008) in physics (quantum mechanics, cosmology), cognitive neuroscience, philosophy of mind, and philosophy (this manuscript would require a REVOLUTION in international academy environment!

    Machine Learning Algorithm for the Scansion of Old Saxon Poetry

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    Several scholars designed tools to perform the automatic scansion of poetry in many languages, but none of these tools deal with Old Saxon or Old English. This project aims to be a first attempt to create a tool for these languages. We implemented a Bidirectional Long Short-Term Memory (BiLSTM) model to perform the automatic scansion of Old Saxon and Old English poems. Since this model uses supervised learning, we manually annotated the Heliand manuscript, and we used the resulting corpus as labeled dataset to train the model. The evaluation of the performance of the algorithm reached a 97% for the accuracy and a 99% of weighted average for precision, recall and F1 Score. In addition, we tested the model with some verses from the Old Saxon Genesis and some from The Battle of Brunanburh, and we observed that the model predicted almost all Old Saxon metrical patterns correctly misclassified the majority of the Old English input verses

    Security Analysis: A Critical Thinking Approach

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    Security Analysis: A Critical-Thinking Approach is for anyone desiring to learn techniques for generating the best answers to complex questions and best solutions to complex problems. It furnishes current and future analysts in national security, homeland security, law enforcement, and corporate security an alternative, comprehensive process for conducting both intelligence analysis and policy analysis. The target audience is upper-division undergraduate students and new graduate students, along with entry-level practitioner trainees. The book centers on a Security Analysis Critical-Thinking Framework that synthesizes critical-thinking and existing analytic techniques. Ample examples are provided to assist readers in comprehending the material. Newly created material includes techniques for analyzing beliefs and political cultures. The book also functions as an introduction to Foreign Policy and Security Studies.https://encompass.eku.edu/ekuopen/1005/thumbnail.jp

    Characterisation of Psychoactive Substances on Paper Using Various Analytical and Chemometrics Approaches

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    In recent years, the growing popularity of NPS within the prison system has contributed to the increase in violence, psychotic episodes and self-harm, undermining the rehabilitation of prisoners. A systematic literature review on the detection of NPS in prison settings was carried out to establish an understanding of current research in the field. MEDLINE, Scopus, PubMed, and Web of Science databases and the grey literature were consulted in line with the PRISMA-S guidelines leading to the identification of 50 articles which met the inclusion criteria. Findings showed that the most prevalent NPS class reported in prison was synthetic cannabinoids mainly deposited on paper matrices and smuggled through the postal services. Laboratory-based techniques i.e., LC-HRMS/MS and GC-MS were predominantly employed for the detection of NPS. The IMS was the only technique used for in-field analysis, highlighting a gap in knowledge for specific and selective in-field analytical techniques for such samples. Therefore, the aim of the thesis was the development of an extraction method of psychoactive substances from paper samples which can be used to facilitate the development of a minimally invasive, highly sensitive, in-field detection technique of psychoactive substances on such samples. Basic extraction properties of paper impregnated with psychoactive substances were investigated to gain knowledge of the process and the percentage recovery using traditional analytical techniques such as LC-UV-Vis and UPLC-PdA-QDa-MS. An extraction method using simulated paper samples impregnated with paracetamol employed as a model substance was optimised and led to the extraction of 80.1 ± 0.7% of paracetamol, over two consecutive extractions. The extraction method was then applied to simulated paper samples impregnated with a ternary mixture of caffeine + cocaine + THJ-018 and the percentage recovery was calculated at 74.7 ± 1.3%, over one extraction. Qualitative analysis of a seized paper sample from prison was carried out to gain insight into the concentration found on such samples, using corroborative analytical techniques i.e., HPLC-PdA-QDa-MS, GC-MS, and NMR, leading to the identification of 5F-ADB. Following up, 5F-ABD was found on another seized paper sample from prison from the same evidence bag as the previous one and was quantified using an optimised and validated UPLC-PdA-QDA-MS method. Concentrations of 5F-ADB calculated on 39 subunits of the sample after three consecutive extractions ranged between 0.00026-0.055 mg/cm2. Furthermore, the percentage recovery of 5F-ADB from simulated paper samples (n=15) was calculated at three concentrations (C1=20 µL of 1 mg/mL, C2=50 µL of 0.1 mg/mL and C3=10 µL 0.1 mg/mL) over five consecutive extractions, this was found to be 98.7 ± 0.8%. A matrix effect study evaluating five paper matrices impregnated with 5F-ADB was performed, the low RSD calculated over the measurement for each type of paper was of suggested that no matrix effect arises when quantifying 5F-ADB on these specific types of samples. A PCA model was developed to understand if Raman spectra of psychoactive substances and cutting agents/adulterants i.e., 5F-PB-22, amphetamine, benzocaine, caffeine, cocaine, diazepam, and paracetamol, as a single neat reference standard, as neat binary mixtures and as soaked or pipetted on simulated paper samples, could have been discriminated. Good discrimination could be achieved between the spectra of neat psychoactive substances and related adulterant/cutting agents reference standard analysed. Discrimination using PCA of the Raman spectra of mixtures of psychoactive substances and related adulterant/cutting agents reference standard has been proved challenging due to the impact of the orientation of oscillations of light waves of the excitation laser irradiating the molecules and the different Raman scattering properties of the compounds in the mixtures. While most of the paper samples impregnated with psychoactive substances and related adulterant/cutting agents formed a ‘mega cluster’ in the scores plot near the BP samples, due to the paper background present in the spectra. However, observation of Raman spectra of such samples showed potential for their discrimination. For instance, when the line plot of the psychoactive substances i.e., 5F-PB-22, amphetamine, cocaine and diazepam reference standard pipetted on the simulated paper samples at five concentrations and collected using Raman Rigaku were examined characteristic peaks of the related reference standard were visible at the highest concentration e.g., 5F-PB-22 pipetted on paper at 20 and 15 mg/mL; cocaine pipetted on paper at 60, 40, 35 and 30 mg/mL. Finally, a minimally invasive extraction of 5F-PB-22 from simulated paper samples using agar gel was developed and optimised using Design of Experiments techniques. This was performed to facilitate the development of a minimally invasive, highly sensitive, in-field NPS detection technique. The screening phase performed using a 25 full-factorial design led to the selection of two statistically significant factors in the process i.e., agar concentration and sonication time. The optimisation phase was then carried out using a two-factor CCD, in which the maximum of the AUC was sought. This identified the optimum agar concentration and sonication time at 2% and 10.95 min, respectively. The extraction time, weight applied, and extraction number were fixed at 120 sec, 85 grams, and 2 extractions, respectively. The model was successfully validated by running five confirmation experiments using the same parameters as the optimised conditions. A 99.67% increase in the extraction of 5F-PB-22 from simulated paper samples was achieved (unoptimised vs. optimised process 1.20 ± 0.09% vs. 2.36 ± 0.19%). Furthermore, the optimised extraction method has also been successfully applied to a seized paper sample known to contain 5F-ADB. Keywords: New Psychoactive Substances, NPS, synthetic cannabinoids, prison

    Sweet Food Preferences and Associated Appetite Regulatory Mechanisms

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    Obesity rates have increased globally alongside intake of palatable, energy-dense foods. Sweet preferring individuals display increased energy intake, experiencing greater risk of developing obesity. Sweet preferences require study to illuminate potential barriers to successful weight loss and responses to sweet foods reformulated with high intensity sweeteners (HIS). The following thesis presents exploratory analyses of two randomised clinical trials investigating; i) the stability of sweet preferences, ii) the relationship between baseline sweet preferences and eating behaviour traits, iii) comparison of two differing dietary weight loss protocols on sweet related outcomes, iv) the impact of acute and repeated consumption of HIS and sucrose sweetened products on subsequent sweet preferences and eating behaviours and finally, v) an exploration of the potential effect of sweet liker phenotypes on the impact of acute and repeated consumption of HIS and sucrose sweetened products on subsequent preferences and eating behaviours. Results showed; i) sweet food preferences were demonstrated to be stable across a period of weight loss, ii) participants with overweight/obesity presented with greater scores on eating behaviour traits involving a loss of control around food, iii) the method of dietary weight loss did not impact outcomes, iv) there was no difference in sucrose and HIS products on subsequent sweet food preferences and v) the reduction in sweet wanting after consuming a sweet food differs between sweet phenotype groups. It is concluded that sweet preferences are a stable trait that does not change during weight loss, and reformulated sweet foods may facilitate a reduction in sugar and energy density whilst maintaining consumer palatability

    Data journeys in the sciences

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    This is the final version. Available from Springer via the DOI in this record. This groundbreaking, open access volume analyses and compares data practices across several fields through the analysis of specific cases of data journeys. It brings together leading scholars in the philosophy, history and social studies of science to achieve two goals: tracking the travel of data across different spaces, times and domains of research practice; and documenting how such journeys affect the use of data as evidence and the knowledge being produced. The volume captures the opportunities, challenges and concerns involved in making data move from the sites in which they are originally produced to sites where they can be integrated with other data, analysed and re-used for a variety of purposes. The in-depth study of data journeys provides the necessary ground to examine disciplinary, geographical and historical differences and similarities in data management, processing and interpretation, thus identifying the key conditions of possibility for the widespread data sharing associated with Big and Open Data. The chapters are ordered in sections that broadly correspond to different stages of the journeys of data, from their generation to the legitimisation of their use for specific purposes. Additionally, the preface to the volume provides a variety of alternative “roadmaps” aimed to serve the different interests and entry points of readers; and the introduction provides a substantive overview of what data journeys can teach about the methods and epistemology of research.European CommissionAustralian Research CouncilAlan Turing Institut

    Emergent quality issues in the supply of Chinese medicinal plants: A mixed methods investigation of their contemporary occurrence and historical persistence

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    Quality issues that emerged centuries ago in Chinese medicinal plants (CMP) were investigated to explore why they still persist in an era of advanced analytical testing and extensive legislation so that a solution to improve CMP quality could be proposed. This is important for 85% of the world’s population who rely on medicinal plants (MP) for primary healthcare considering the adverse events, including fatalities that arise from such quality issues. CMP are the most prevalent medicinal plants globally. This investigation used mixed-methods, including 15 interviews with CMP expert key informants (KI), together with thematic analysis that identified the main CMP quality issues, why they persisted, and informed solutions. An unexplained case example, Eleutherococcus nodiflorus (EN), was analysed by collection of 106 samples of EN, its known toxic adulterant Periploca sepium (PS), and a related substitute, Eleutherococcus senticosus (ES), across mainland China, Taiwan and the UK. Authenticity of the samples was determined using High-performance thinlayer chromatography. Misidentification, adulteration, substitution and toxicity were the main CMP quality issues identified. Adulteration was found widespread globally with 57.4% EN found authentic, and 24.6% adulterated with cardiotoxic PS, mostly at markets and traditional pharmacies. The EN study further highlighted that the reason CMP quality issues persisted was due to the laboratory-bound nature of analytical methods and testing currently used that leave gaps in detection throughout much of the supply chain. CMP quality could be more effectively tested with patented analytical technology (PAT) and simpler field-based testing including indicator strip tests. Education highlighting the long-term economic value and communal benefit of delivering better quality CMP to consumers was recommended in favour of the financial motivation for actions that lead to the persistence of well-known and recurrent CMP quality issues

    Changing Priorities. 3rd VIBRArch

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    In order to warrant a good present and future for people around the planet and to safe the care of the planet itself, research in architecture has to release all its potential. Therefore, the aims of the 3rd Valencia International Biennial of Research in Architecture are: - To focus on the most relevant needs of humanity and the planet and what architectural research can do for solving them. - To assess the evolution of architectural research in traditionally matters of interest and the current state of these popular and widespread topics. - To deepen in the current state and findings of architectural research on subjects akin to post-capitalism and frequently related to equal opportunities and the universal right to personal development and happiness. - To showcase all kinds of research related to the new and holistic concept of sustainability and to climate emergency. - To place in the spotlight those ongoing works or available proposals developed by architectural researchers in order to combat the effects of the COVID-19 pandemic. - To underline the capacity of architectural research to develop resiliency and abilities to adapt itself to changing priorities. - To highlight architecture's multidisciplinarity as a melting pot of multiple approaches, points of view and expertise. - To open new perspectives for architectural research by promoting the development of multidisciplinary and inter-university networks and research groups. For all that, the 3rd Valencia International Biennial of Research in Architecture is open not only to architects, but also for any academic, practitioner, professional or student with a determination to develop research in architecture or neighboring fields.Cabrera Fausto, I. (2023). Changing Priorities. 3rd VIBRArch. Editorial Universitat Politècnica de València. https://doi.org/10.4995/VIBRArch2022.2022.1686

    Human Body Scattering Effects at Millimeter Waves Frequencies for Future 5G Systems and Beyond

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    [ES] Se espera que las futuras comunicaciones móviles experimenten una revolución técnica que vaya más allá de las velocidades de datos de Gbps y reduzca las latencias de las velocidades de datos a niveles muy cercanos al milisegundo. Se han investigado nuevas tecnologías habilitadoras para lograr estas exigentes especificaciones. Y la utilización de las bandas de ondas milimétricas, donde hay mucho espectro disponible, es una de ellas. Debido a las numerosas dificultades técnicas asociadas a la utilización de esta banda de frecuencias, se necesitan complicados modelos de canal para anticipar las características del canal de radio y evaluar con precisión el rendimiento de los sistemas celulares en milimétricas. En concreto, los modelos de propagación más precisos son los basados en técnicas de trazado de rayos deterministas. Pero estas técnicas tienen el estigma de ser computacionalmente exigentes, y esto dificulta su uso para caracterizar el canal de radio en escenarios interiores complejos y dinámicos. La complejidad de la caracterización de estos escenarios depende en gran medida de la interacción del cuerpo humano con el entorno radioeléctrico, que en las ondas milimétricas suele ser destructiva y muy impredecible. Por otro lado, en los últimos años, la industria de los videojuegos ha desarrollado potentes herramientas para entornos hiperrealistas, donde la mayor parte de los avances en esta emulación de la realidad tienen que ver con el manejo de la luz. Así, los motores gráficos de estas plataformas se han vuelto cada vez más eficientes para manejar grandes volúmenes de información, por lo que son ideales para emular el comportamiento de la propagación de las ondas de radio, así como para reconstruir un escenario interior complejo. Por ello, en esta Tesis se ha aprovechado la capacidad computacional de este tipo de herramientas para evaluar el canal radioeléctrico milimétricas de la forma más eficiente posible. Esta Tesis ofrece unas pautas para optimizar la propagación de la señal en milimétricas en un entorno interior dinámico y complejo, para lo cual se proponen tres objetivos principales. El primer objetivo es evaluar los efectos de dispersión del cuerpo humano cuando interactúa con el canal de propagación. Una vez evaluado, se propuso un modelo matemático y geométrico simplificado para calcular este efecto de forma fiable y rápida. Otro objetivo fue el diseño de un reflector pasivo modular en milimétricas, que optimiza la cobertura en entornos de interior, evitando la interferencia del ser humano en la propagación. Y, por último, se diseñó un sistema de apuntamiento del haz predictivo en tiempo real, para que opere con el sistema de radiación en milimétricas, cuyo objetivo es evitar las pérdidas de propagación causadas por el cuerpo humano en entornos interiores dinámicos y complejos.[CA] S'espera que les futures comunicacions mòbils experimenten una revolució tècnica que vaja més enllà de les velocitats de dades de Gbps i reduïsca les latències de les velocitats de dades a nivells molt pròxims al milisegundo. S'han investigat noves tecnologies habilitadoras per a aconseguir estes exigents especificacions. I la utilització de les bandes d'ones millimètriques, on hi ha molt espectre disponible, és una d'elles. A causa de les nombroses dificultats tècniques associades a la utilització d'esta banda de freqüències, es necessiten complicats models de canal per a anticipar les característiques del canal de ràdio i avaluar amb precisió el rendiment dels sistemes cellulars en millimètriques. En concret, els models de propagació més precisos són els basats en tècniques de traçat de rajos deterministes. Però estes tècniques tenen l'estigma de ser computacionalment exigents, i açò dificulta el seu ús per a caracteritzar el canal de ràdio en escenaris interiors complexos i dinàmics. La complexitat de la caracterització d'estos escenaris depén en gran manera de la interacció del cos humà amb l'entorn radioelèctric, que en les ones millimètriques sol ser destructiva i molt impredicible. D'altra banda, en els últims anys, la indústria dels videojocs ha desenrotllat potents ferramentes per a entorns hiperrealistes, on la major part dels avanços en esta emulació de la realitat tenen a veure amb el maneig de la llum. Així, els motors gràfics d'estes plataformes s'han tornat cada vegada més eficients per a manejar grans volums d'informació, per la qual cosa són ideals per a emular el comportament de la propagació de les ones de ràdio, així com per a reconstruir un escenari interior complex. Per això, en esta Tesi s'ha aprofitat la capacitat computacional d'este tipus de ferramentes per a avaluar el canal radioelèctric millimètriques de la manera més eficient possible. Esta Tesi oferix unes pautes per a optimitzar la propagació del senyal en millimètriques en un entorn interior dinàmic i complex, per a la qual cosa es proposen tres objectius principals. El primer objectiu és avaluar els efectes de dispersió del cos humà quan interactua amb el canal de propagació. Una vegada avaluat, es va proposar un model matemàtic i geomètric simplificat per a calcular este efecte de forma fiable i ràpida. Un altre objectiu va ser el disseny d'un reflector passiu modular en millimètriques, que optimitza la cobertura en entorns d'interior, evitant la interferència del ser humà en la propagació, per a així evitar pèrdues de propagació addicionals. I, finalment, es va dissenyar un sistema d'apuntament del feix predictiu en temps real, perquè opere amb el sistema de radiació en millimètriques, l'objectiu del qual és evitar les pèrdues de propagació causades pel cos humà en entorns interiors dinàmics i complexos.[EN] Future mobile communications are expected to experience a technical revolution that goes beyond Gbps data rates and reduces data rate latencies to levels very close to a millisecond. New enabling technologies have been researched to achieve these demanding specifications. The utilization of mmWave bands, where a lot of spectrum is available, is one of them. Due to the numerous technical difficulties associated with using this frequency band, complicated channel models are necessary to anticipate the radio channel characteristics and to accurately evaluate the performance of cellular systems in mmWave. In particular, the most accurate propagation models are those based on deterministic ray tracing techniques. But these techniques have the stigma of being computationally intensive, and this makes it difficult to use them to characterize the radio channel in complex and dynamic indoor scenarios. The complexity of characterizing these scenarios depends largely on the interaction of the human body with the radio environment, which at mmWaves is often destructive and highly unpredictable. On the other hand, in recent years, the video game industry has developed powerful tools for hyper-realistic environments, where most of the progress in this reality emulation has to do with the handling of light. Therefore, the graphic engines of these platforms have become more and more efficient to handle large volumes of information, becoming ideal to emulate the radio wave propagation behavior, as well as to reconstruct a complex interior scenario. Therefore, in this Thesis one has taken advantage of the computational capacity of this type of tools to evaluate the mmWave radio channel in the most efficient way possible. This Thesis offers some guidelines to optimize the signal propagation in mmWaves in a dynamic and complex indoor environment, for which three main objectives are proposed. The first objective has been to evaluate the scattering effects of the human body when it interacts with the propagation channel. Once evaluated, a simplified mathematical and geometrical model has been proposed to calculate this effect in a reliable and fast way. Another objective has been the design of a modular passive reflector in mmWaves, which optimizes the coverage in indoor environments, avoiding human interference in the propagation, in order to avoid its harmful scattering effects. And finally, a real-time predictive beam steering system has been designed for the mmWaves radiation system, in order to avoid propagation losses caused by the human body in dynamic and complex indoor environments.Romero Peña, JS. (2022). Human Body Scattering Effects at Millimeter Waves Frequencies for Future 5G Systems and Beyond [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/19132
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