Sensitivity analysis of oscillator models in the space of phase-response curves: Oscillators as open systems

Oscillator models are central to the study of system properties such as entrainment or synchronization. Due to their nonlinear nature, few system-theoretic tools exist to analyze those models. The paper develops a sensitivity analysis for phase-response curves, a fundamental one-dimensional phase reduction of oscillator models. The proposed theoretical and numerical analysis tools are illustrated on several system-theoretic questions and models arising in the biology of cellular rhythms

Emergence and combinatorial accumulation of jittering regimes in spiking oscillators with delayed feedback

Interaction via pulses is common in many natural systems, especially neuronal. In this article we study one of the simplest possible systems with pulse interaction: a phase oscillator with delayed pulsatile feedback. When the oscillator reaches a specific state, it emits a pulse, which returns after propagating through a delay line. The impact of an incoming pulse is described by the oscillator's phase reset curve (PRC). In such a system we discover an unexpected phenomenon: for a sufficiently steep slope of the PRC, a periodic regular spiking solution bifurcates with several multipliers crossing the unit circle at the same parameter value. The number of such critical multipliers increases linearly with the delay and thus may be arbitrary large. This bifurcation is accompanied by the emergence of numerous "jittering" regimes with non-equal interspike intervals (ISIs). Each of these regimes corresponds to a periodic solution of the system with a period roughly proportional to the delay. The number of different "jittering" solutions emerging at the bifurcation point increases exponentially with the delay. We describe the combinatorial mechanism that underlies the emergence of such a variety of solutions. In particular, we show how a periodic solution exhibiting several distinct ISIs can imply the existence of multiple other solutions obtained by rearranging of these ISIs. We show that the theoretical results for phase oscillators accurately predict the behavior of an experimentally implemented electronic oscillator with pulsatile feedback

Perspectives on the Neuroscience of Cognition and Consciousness

The origin and current use of the concepts of computation, representation and information in Neuroscience are examined and conceptual flaws are identified which vitiate their usefulness for addressing problems of the neural basis of Cognition and Consciousness. In contrast, a convergence of views is presented to support the characterization of the Nervous System as a complex dynamical system operating in the metastable regime, and capable of evolving to configurations and transitions in phase space with potential relevance for Cognition and Consciousness

Synchronous Behavior of Two Coupled Electronic Neurons

We report on experimental studies of synchronization phenomena in a pair of analog electronic neurons (ENs). The ENs were designed to reproduce the observed membrane voltage oscillations of isolated biological neurons from the stomatogastric ganglion of the California spiny lobster Panulirus interruptus. The ENs are simple analog circuits which integrate four dimensional differential equations representing fast and slow subcellular mechanisms that produce the characteristic regular/chaotic spiking-bursting behavior of these cells. In this paper we study their dynamical behavior as we couple them in the same configurations as we have done for their counterpart biological neurons. The interconnections we use for these neural oscillators are both direct electrical connections and excitatory and inhibitory chemical connections: each realized by analog circuitry and suggested by biological examples. We provide here quantitative evidence that the ENs and the biological neurons behave similarly when coupled in the same manner. They each display well defined bifurcations in their mutual synchronization and regularization. We report briefly on an experiment on coupled biological neurons and four dimensional ENs which provides further ground for testing the validity of our numerical and electronic models of individual neural behavior. Our experiments as a whole present interesting new examples of regularization and synchronization in coupled nonlinear oscillators.Comment: 26 pages, 10 figure

Synchronization of spiral wave patterns in two-layer 2D lattices of nonlocally coupled discrete oscillators

This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Chaos 29, 053105 (2019) and may be found at https://doi.org/10.1063/1.5092352.The paper describes the effects of mutual and external synchronization of spiral wave structures in two coupled two-dimensional lattices of coupled discrete-time oscillators. Each lattice is given by a 2D N×N network of nonlocally coupled Nekorkin maps which model neuronal activity. We show numerically that spiral wave structures, including spiral wave chimeras, can be synchronized and establish the mechanism of the synchronization scenario. Our numerical studies indicate that when the coupling strength between the lattices is sufficiently weak, only a certain part of oscillators of the interacting networks is imperfectly synchronized, while the other part demonstrates a partially synchronous behavior. If the spatiotemporal patterns in the lattices do not include incoherent cores, imperfect synchronization is realized for most oscillators above a certain value of the coupling strength. In the regime of spiral wave chimeras, the imperfect synchronization of all oscillators cannot be achieved even for sufficiently large values of the coupling strength.DFG, 163436311, SFB 910: Kontrolle selbstorganisierender nichtlinearer Systeme: Theoretische Methoden und Anwendungskonzept

Resonate and Fire Neuron with Fixed Magnetic Skyrmions

In the brain, the membrane potential of many neurons oscillates in a subthreshold damped fashion and fire when excited by an input frequency that nearly equals their eigen frequency. In this work, we investigate theoretically the artificial implementation of such "resonate-and-fire" neurons by utilizing the magnetization dynamics of a fixed magnetic skyrmion in the free layer of a magnetic tunnel junction (MTJ). To realize firing of this nanomagnetic implementation of an artificial neuron, we propose to employ voltage control of magnetic anisotropy or voltage generated strain as an input (spike or sinusoidal) signal, which modulates the perpendicular magnetic anisotropy (PMA). This results in continual expansion and shrinking (i.e. breathing) of a skyrmion core that mimics the subthreshold oscillation. Any subsequent input pulse having an interval close to the breathing period or a sinusoidal input close to the eigen frequency drives the magnetization dynamics of the fixed skyrmion in a resonant manner. The time varying electrical resistance of the MTJ layer due to this resonant oscillation of the skyrmion core is used to drive a Complementary Metal Oxide Semiconductor (CMOS) buffer circuit, which produces spike outputs. By rigorous micromagnetic simulation, we investigate the interspike timing dependence and response to different excitatory and inhibitory incoming input pulses. Finally, we show that such resonate and fire neurons have potential application in coupled nanomagnetic oscillator based associative memory arrays

Desynchronization of systems of coupled Hindmarsh-Rose oscillators

It is widely assumed that neural activity related to synchronous rhythms of large portions of neurons in specific locations of the brain is responsible for the pathology manifested in patients' uncontrolled tremor and other similar diseases. To model such systems Hindmarsh-Rose (HR) oscillators are considered as appropriate as they mimic the qualitative behaviour of neuronal firing. Here we consider a large number of identical HR-oscillators interacting through the mean field created by the corresponding components of all oscillators. Introducing additional coupling by feedback of Pyragas type, proportional to the difference between the current value of the mean-field and its value some time in the past, Rosenblum and Pikovsky (Phys. Rev. E 70, 041904, 2004) demonstrated that the desirable desynchronization could be achieved with appropriate set of parameters for the system. Following our experience with stabilization of unstable steady states in dynamical systems, we show that by introducing a variable delay, desynchronization is obtainable for much wider range of parameters and that at the same time it becomes more pronounced.Comment: 5 pages, 2 figures, RevTe