Quantitative Models in Life Science Business

This open access book explores the field of life science business from a multidisciplinary perspective. Applying statistical, mathematical, game-theoretic, and data science tools to pharmaceutical and biotechnology business endeavors, the book describes value creation, value maintenance, and value realization in the life sciences as a sequence of processes using the quantitative language of applied mathematics. Written by experts from a variety of fields, the contributions illustrate the shift from a deterministic to a stochastic view of the processes involved, offering a new perspective on life sciences economics. The book covers topics such as valuing and managing intellectual property in life science, licensing in the pharmaceutical business, outsourcing pharmaceutical R&D, and stochastic modelling of a pharmaceutical supply chain. The book will appeal to scholars of economics and the life sciences, as well as to professionals in chemical and pharmaceutical industries

Novel approaches for food safety management and communication

The current safety and quality controls in the food chain are lacking or inadequately applied and fail to prevent microbial and/or chemical contamination of food products, which leads to reduced confidence among consumers. On the other hand to meet market demands food business operators (producers, retailers, resellers) and regulators need to develop and apply structured quality and safety assurance systems based on thorough risk analysis and prevention, through monitoring, recording and controlling of critical parameters covering the entire product's life cycle. However the production, supply, and processing sectors of the food chain are fragmented and this lack of cohesion results in a failure to adopt new and innovative technologies, products and processes. The potential of using information technologies, for example, data storage, communication, cloud, in tandem with data science, for example, data mining, pattern recognition, uncertainty modelling, artificial intelligence, etc., through the whole food chain including processing within the food industry, retailers and even consumers, will provide stakeholders with novel tools regarding the implementation of a more efficient food safety management system

Quantitative Models in Life Science Business

This open access book explores the field of life science business from a multidisciplinary perspective. Applying statistical, mathematical, game-theoretic, and data science tools to pharmaceutical and biotechnology business endeavors, the book describes value creation, value maintenance, and value realization in the life sciences as a sequence of processes using the quantitative language of applied mathematics. Written by experts from a variety of fields, the contributions illustrate the shift from a deterministic to a stochastic view of the processes involved, offering a new perspective on life sciences economics. The book covers topics such as valuing and managing intellectual property in life science, licensing in the pharmaceutical business, outsourcing pharmaceutical R&D, and stochastic modelling of a pharmaceutical supply chain. The book will appeal to scholars of economics and the life sciences, as well as to professionals in chemical and pharmaceutical industries

Real-time supply chain simulation: a big data-driven approach

Simulation of Supply Chains comprises huge amounts of data, resulting in numerous entities flowing in the model. These networks are highly dynamic systems, where entities' relationships and other elements evolve with time, paving the way for real-time Supply Chain decision-support tools capable of using real data. In light of this, a solution comprising of a Big Data Warehouse to store relevant data and a simulation model of an automotive plant, are being developed. The purpose of this paper is to address the modelling approach, which allowed the simulation model to automatically adapt to the data stored in a Big Data Warehouse and thus adapt to new scenarios without manual intervention. The main characteristics of the conceived solution were demonstrated, with emphasis to the real-time and the ability to allow the model to load the state of the system from the Big Data Warehouse.This work has been supported by FCT - Fundacao para a Ciencia e Tecnologia within the Project Scope: UID/CEC/00319/2019 and by the Doctoral scholarship PDE/BDE/114566/2016 funded by FCT, the Portuguese Ministry of Science, Technology and Higher Education, through national funds, and co-financed by the European Social Fund (ESF) through the Operational Programme for Human Capital (POCH)

Judgement and supply chain dynamics

Forecasting demand at the individual stock-keeping-unit (SKU) level often necessitates the use of statistical methods, such as exponential smoothing. In some organizations, however, statistical forecasts will be subject to judgemental adjustments by managers. Although a number of empirical and ‘laboratory’ studies have been performed in this area, no formal OR modelling has been conducted to offer insights into the impact such adjustments may have on supply chain performance and the potential development of mitigation mechanisms. This is because of the associated dynamic complexity and the situation-specific nature of the problem at hand. In conjunction with appropriate stock control rules, demand forecasts help decide how much to order. It is a common practice that replenishment orders may also be subject to judgemental intervention, adding further to the dynamic system complexity and interdependence. The system dynamics (SD) modelling method can help advance knowledge in this area, where mathematical modelling cannot accommodate the associated complexity. This study, which constitutes part of a UK government funded (EPSRC) project, uses SD models to evaluate the effects of forecasting and ordering adjustments for a wide set of scenarios involving: three different inventory policies; seven different (combinations of) points of intervention; and four different (combinations of) types of judgmental intervention (optimistic and pessimistic). The results enable insights to be gained into the performance of the entire supply chain. An agenda for further research concludes the paper

Decision support for build-to-order supply chain management through multiobjective optimization

This paper aims to identify the gaps in decision-making support based on multiobjective optimization for build-to-order supply chain management (BTOSCM). To this end, it reviews the literature available on modelling build-to-order supply chains (BTO-SC) with the focus on adopting multiobjective optimization (MOO) techniques as a decision support tool. The literature has been classified based on the nature of the decisions in different part of the supply chain, and the key decision areas across a typical BTO-SC are discussed in detail. Available software packages suitable for supporting decision making in BTO supply chains are also identified and their related solutions are outlined. The gap between the modelling and optimization techniques developed in the literature and the decision support needed in practice are highlighted and future research directions to better exploit the decision support capabilities of MOO are proposed

Decision support for build-to-order supply chain management through multiobjective optimization

This is the post-print version of the final paper published in International Journal of Production Economics. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2010 Elsevier B.V.This paper aims to identify the gaps in decision-making support based on multiobjective optimization (MOO) for build-to-order supply chain management (BTO-SCM). To this end, it reviews the literature available on modelling build-to-order supply chains (BTO-SC) with the focus on adopting MOO techniques as a decision support tool. The literature has been classified based on the nature of the decisions in different part of the supply chain, and the key decision areas across a typical BTO-SC are discussed in detail. Available software packages suitable for supporting decision making in BTO supply chains are also identified and their related solutions are outlined. The gap between the modelling and optimization techniques developed in the literature and the decision support needed in practice are highlighted. Future research directions to better exploit the decision support capabilities of MOO are proposed. These include: reformulation of the extant optimization models with a MOO perspective, development of decision supports for interfaces not involving manufacturers, development of scenarios around service-based objectives, development of efficient solution tools, considering the interests of each supply chain party as a separate objective to account for fair treatment of their requirements, and applying the existing methodologies on real-life data sets.Brunel Research Initiative and Enterprise Fund (BRIEF

Modelling an End to End Supply Chain system Using Simulation

Within the current uncertain environment industries are predominantly faced with various challenges resulting in greater need for skilled management and adequate technique as well as tools to manage Supply Chains (SC) efficiently. Derived from this observation is the need to develop a generic/reusable modelling framework that would allow firms to analyse their operational performance over time (Mackulak and Lawrence 1998, Beamon and Chen 2001, Petrovic 2001, Lau et al. 2008, Khilwani et al. 2011, Cigollini et al. 2014). However for this to be effectively managed the simulation modelling efforts should be directed towards identifying the scope of the SC and the key processes performed between players. Purpose: The research attempts to analyse trends in the field of supply chain modelling using simulation and provide directions for future research by reviewing existing Operations Research/Operations Management (OR/OM) literature. Structural and operational complexities as well as different business processes within various industries are often limiting factors during modelling efforts. Successively, this calls for the end to end (E2E) SC modelling framework where the generic processes, related policies and techniques could be captured and supported by the powerful capabilities of simulation. Research Approach: Following Mitroff’s (1974) scientific inquiry model and Sargent (2011) this research will adopt simulation methodology and focus on systematic literature review in order to establish generic OR processes and differentiate them from those which are specific to certain industries. The aim of the research is provide a clear and informed overview of the existing literature in the area of supply chain simulation. Therefore through a profound examination of the selected studies a conceptual model will be design based on the selection of the most commonly used SC Processes and simulation techniques used within those processes. The description of individual elements that make up SC processes (Hermann and Pundoor 2006) will be defined using building blocks, which are also known as Process Categories. Findings and Originality: This paper presents an E2E SC simulation conceptual model realised through means of systematic literature review. Practitioners have adopted the term E2E SC while this is not extensively featured within academic literature. The existing SC studies lack generality in regards to capturing the entire SC within one methodological framework, which this study aims to address. Research Impact: A systematic review of the supply chain and simulation literature takes an integrated and holistic assessment of an E2E SC, from market-demand scenarios through order management and planning processes, and on to manufacturing and physical distribution. Thus by providing significant advances in understanding of the theory, methods used and applicability of supply chain simulation, this paper will further develop a body of knowledge within this subject area. Practical Impact: The paper will empower practitioners’ knowledge and understanding of the supply chain processes characteristics that can be modelled using simulation. Moreover it will facilitate a selection of specific data required for the simulation in accordance to the individual needs of the industry