Deep Learning in Cardiology

The medical field is creating large amount of data that physicians are unable to decipher and use efficiently. Moreover, rule-based expert systems are inefficient in solving complicated medical tasks or for creating insights using big data. Deep learning has emerged as a more accurate and effective technology in a wide range of medical problems such as diagnosis, prediction and intervention. Deep learning is a representation learning method that consists of layers that transform the data non-linearly, thus, revealing hierarchical relationships and structures. In this review we survey deep learning application papers that use structured data, signal and imaging modalities from cardiology. We discuss the advantages and limitations of applying deep learning in cardiology that also apply in medicine in general, while proposing certain directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table

Identifying Humans by the Shape of Their Heartbeats and Materials by Their X-Ray Scattering Profiles

Security needs at access control points presents itself in the form of human identification and/or material identification. The field of Biometrics deals with the problem of identifying individuals based on the signal measured from them. One approach to material identification involves matching their x-ray scattering profiles with a database of known materials. Classical biometric traits such as fingerprints, facial images, speech, iris and retinal scans are plagued by potential circumvention they could be copied and later used by an impostor. To address this problem, other bodily traits such as the electrical signal acquired from the brain (electroencephalogram) or the heart (electrocardiogram) and the mechanical signals acquired from the heart (heart sound, laser Doppler vibrometry measures of the carotid pulse) have been investigated. These signals depend on the physiology of the body, and require the individual to be alive and present during acquisition, potentially overcoming circumvention. We investigate the use of the electrocardiogram (ECG) and carotid laser Doppler vibrometry (LDV) signal, both individually and in unison, for biometric identity recognition. A parametric modeling approach to system design is employed, where the system parameters are estimated from training data. The estimated model is then validated using testing data. A typical identity recognition system can operate in either the authentication (verification) or identification mode. The performance of the biometric identity recognition systems is evaluated using receiver operating characteristic (ROC) or detection error tradeoff (DET) curves, in the authentication mode, and cumulative match characteristic (CMC) curves, in the identification mode. The performance of the ECG- and LDV-based identity recognition systems is comparable, but is worse than those of classical biometric systems. Authentication performance below 1% equal error rate (EER) can be attained when the training and testing data are obtained from a single measurement session. When the training and testing data are obtained from different measurement sessions, allowing for a potential short-term or long-term change in the physiology, the authentication EER performance degrades to about 6 to 7%. Leveraging both the electrical (ECG) and mechanical (LDV) aspects of the heart, we obtain a performance gain of over 50%, relative to each individual ECG-based or LDV-based identity recognition system, bringing us closer to the performance of classical biometrics, with the added advantage of anti-circumvention. We consider the problem of designing combined x-ray attenuation and scatter systems and the algorithms to reconstruct images from the systems. As is the case within a computational imaging framework, we tackle the problem by taking a joint system and algorithm design approach. Accurate modeling of the attenuation of incident and scattered photons within a scatter imaging setup will ultimately lead to more accurate estimates of the scatter densities of an illuminated object. Such scattering densities can then be used in material classification. In x-ray scatter imaging, tomographic measurements of the forward scatter distribution are used to infer scatter densities within a volume. A mask placed between the object and the detector array provides information about scatter angles. An efficient computational implementation of the forward and backward model facilitates iterative algorithms based upon a Poisson log-likelihood. The design of the scatter imaging system influences the algorithmic choices we make. In turn, the need for efficient algorithms guides the system design. We begin by analyzing an x-ray scatter system fitted with a fanbeam source distribution and flat-panel energy-integrating detectors. Efficient algorithms for reconstructing object scatter densities from scatter measurements made on this system are developed. Building on the fanbeam source, energy-integrating at-panel detection model, we develop a pencil beam model and an energy-sensitive detection model. The scatter forward models and reconstruction algorithms are validated on simulated, Monte Carlo, and real data. We describe a prototype x-ray attenuation scanner, co-registered with the scatter system, which was built to provide complementary attenuation information to the scatter reconstruction and present results of applying alternating minimization reconstruction algorithms on measurements from the scanner

Noninvasive methods for children\u27s cholesterol level determination

Today, there is a controversy about the role of cholesterol in infants and the measurement and management of blood cholesterol in children. Several scientific evidences are supporting relationship between elevated blood cholesterol in children and high cholesterol in adults and development of adult arteriosclerotic diseases such as cardiovascular and cerebrovascular disease. Therefore controlling the level of blood cholesterol in children is very important for the health of the whole population. Non-invasive methods are much more convenient for the children because of their anxieties about blood examinations. In this paper we will present a new try to find non-invasive methods for determining the level of blood cholesterol in children with the use of intelligent system

Surface EMG decomposition using a novel approach for blind source separation

We introduce a new method to perform a blind deconvolution of the surface electromyogram (EMG) signals generated by isometric muscle contractions. The method extracts the information from the raw EMG signals detected only on the skin surface, enabling longtime noninvasive monitoring of the electromuscular properties. Its preliminary results show that surface EMG signals can be used to determine the number of active motor units, the motor unit firing rate and the shape of the average action potential in each motor unit

Aerospace medicine and biology: A continuing bibliography with indexes (supplement 359)

This bibliography lists 164 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during Jan. 1992. Subject coverage includes: aerospace medicine and physiology, life support systems and man/system technology, protective clothing, exobiology and extraterrestrial life, planetary biology, and flight crew behavior and performance