Stevens Johnson syndrome/toxic epidermal necrolysis and erythema exsudativum multiforme

In the past, definition and name giving of erythema exsudativum multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis have been confusing. However, after a consensus classification, which separates erythema exsudativum multiforme from Stevens-Johnson syndrome and toxic epidermal necrolysis, it is now generally accepted that Stevens-Johnson syndrome and toxic epidermal necrolysis are variants within a continuous spectrum of severe, potentially fatal, mucocutaneous, mainly adverse drug reactions, whereas erythema exsudativum multiforme is a distinct, generally more mild entity with different clinical signs, mainly precipitated by infections e.g. herpes simplex virus.</p

Lamotrigine-induced Stevens-Johnson syndrome in a 25 year old lady

Stevens-Johnson syndrome (SJS) is an immune-complex mediated hypersensitivity reaction and has been linked as an adverse side effect to many drugs. This case is about a 25 year old woman who had lamotrigine-induced Stevens-Johnson syndrome which is known to occur but is rare. Lamotrigine, an anticonvulsive medication and also a commonly used mood stabilizer was prescribed to the patient to treat symptoms of anxiety and depression. The patient developed Stevens-Johnson syndrome 5 weeks after start of therapy. This case is discussed for its relevance to the use of lamotrigine which is currently prescribed very commonly in psychiatric practices

ACECLOFENAC-INDUCED STEVENS-JOHNSON SYNDROME AFTER ONE SINGLE DOSE: A MAIDEN CASE REPORT

Drugs are known to cause various adverse drug reactions involving major organ systems. Skin-related adverse reactions are very common and range from a simple rash to life-threatening condition like Stevens-Johnson syndrome. Various drugs are known to cause skin reactions which include antiepileptics, analgesics, antibiotics, and proton-pump inhibitors. Nonsteroidal anti-inflammatory drugs causing life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis are very rare and only few case reports are published. Hence, we report a case of Aceclofenac-induced Stevens-Johnson syndrome after single time administration in a tertiary care hospital in India

Stevens-Johnson Syndrome triggered by chemical hair relaxer: a case report

This case report describes a 41-year-old Afro-Caribbean lady presenting with a constellation of pyrexia, conjunctivitis, arthralgia, sterile dysuria, apthous ulceration, labial crusting and widespread erythema multiforme. A diagnosis of Stevens-Johnson Syndrome was made. She had taken no medications recently (the most common precipitant of Stevens-Johnson Syndrome) and a full screen for the common and atypical bacterial and viral triggers was negative. The identified trigger was the use of a chemical hair relaxant treatment a few days previously. With supportive measures and a course of oral prednisolone, the patient quickly improved and made a full recovery. This case highlights the importance of considering occupational and recreational precipitants of Stevens-Johnson Syndrome

Carbamazepine induced Stevens Johnson Syndrome: a case report from a tertiary care hospital

Stevens Johnson Syndrome is a rare but life-threatening skin disease and Carbamazepine is considered as one of the most common cause. The reported frequency of serious Carbamazepine hypersensitivity reaction is between 1/1000 and 1/10000 new exposures to the drug. Here, we report a case of a 40 year old female patient, who developed multiple ulcerative lesions all over the body three days after starting treatment with Carbamazepine for Trigeminal Neuralgia. (Worldwide Unique Number- 2017-58502 and AMC Report Number- BJGMC-Pune/Nov-2017/BBG-1860) Stevens Johnson Syndrome was diagnosed. Carbamazepine was withdrawn, and the patient was treated with topical and intravenous antibiotics. A biopsy was done which confirmed the diagnosis of Stevens Johnson Syndrome

Sulfadiazine induced Stevens Johnson syndrome in toxoplasmosis patient: a case report

Stevens johnson syndrome is an acute, self-limited disease, presenting as severe mucosal erosions with widespread erythematous, cutaneous macules or atypical targets. Even though sulfadiazine has been mainly associated with haematological-related adverse effects, sulfadiazine induced skin necrosis has received less attention or went unrecognized. Here is a 29-year- old Indian male received T. Sulfadiazine 500mg 1-1-1-1 and experienced a severe skin reaction which was diagnosed as stevens johnson syndrome (SJS). The above drug will be implicated in cases of stevens johnson syndrome (SJS)/toxic epidermal necrosis (TEN). There are few case reports of that have been associated with stevens johnson syndrome (SJS)/toxic epidermal necrosis (TEN). We hope that this case report creates awareness to the health care professionals. Clinicians must be aware of these adverse reactions and advise their patients to contact them as soon as they observe any unexpected clinical response. Early diagnosis helps the clinician to elude secondary infection and subsequent complications. The offending drug should be discontinued and never be rechallenged.

Stevens-Johnson Syndrome

This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of Stevens-Johnson Syndrome

Tramadol-induced Stevens-Johnson syndrome

Stevens-Johnson syndrome and toxic epidermal necrolysis are acute and severe life-threatening allergic reactions. Their incidences in Thailand may be underestimated due to a lacking of reports. The etiologies of Stevens-Johnson syndrome/toxic epidermal necrolysis are numerous; drugs are the most important causes. Not only well-known drugs, e.g. antibiotics, antiepileptics and NSAIDs, but also any drugs can be the cause of Stevens-Johnson syndrome/toxic epidermal necrolysis. Hereby we report a 20 years old Thai male presenting with high-grade fever with extensive detachment of epidermis and erosion of mucocutaneous membrane for 3 days. The patient had taken tramadol. The dermatopathology was compatible with Stevens-Johnson syndrome. The serology revealed positive dengue Immunoglobulin G. The final diagnosis was dengue fever with Stevens-Johnson syndrome. We report a case of Stevens-Johnson syndrome from tramadol