Coding Strategies for Cochlear Implants Under Adverse Environments

Cochlear implants are electronic prosthetic devices that restores partial hearing in patients with severe to profound hearing loss. Although most coding strategies have significantly improved the perception of speech in quite listening conditions, there remains limitations on speech perception under adverse environments such as in background noise, reverberation and band-limited channels, and we propose strategies that improve the intelligibility of speech transmitted over the telephone networks, reverberated speech and speech in the presence of background noise. For telephone processed speech, we propose to examine the effects of adding low-frequency and high- frequency information to the band-limited telephone speech. Four listening conditions were designed to simulate the receiving frequency characteristics of telephone handsets. Results indicated improvement in cochlear implant and bimodal listening when telephone speech was augmented with high frequency information and therefore this study provides support for design of algorithms to extend the bandwidth towards higher frequencies. The results also indicated added benefit from hearing aids for bimodal listeners in all four types of listening conditions. Speech understanding in acoustically reverberant environments is always a difficult task for hearing impaired listeners. Reverberated sounds consists of direct sound, early reflections and late reflections. Late reflections are known to be detrimental to speech intelligibility. In this study, we propose a reverberation suppression strategy based on spectral subtraction to suppress the reverberant energies from late reflections. Results from listening tests for two reverberant conditions (RT60 = 0.3s and 1.0s) indicated significant improvement when stimuli was processed with SS strategy. The proposed strategy operates with little to no prior information on the signal and the room characteristics and therefore, can potentially be implemented in real-time CI speech processors. For speech in background noise, we propose a mechanism underlying the contribution of harmonics to the benefit of electroacoustic stimulations in cochlear implants. The proposed strategy is based on harmonic modeling and uses synthesis driven approach to synthesize the harmonics in voiced segments of speech. Based on objective measures, results indicated improvement in speech quality. This study warrants further work into development of algorithms to regenerate harmonics of voiced segments in the presence of noise

Single Channel Speech Enhancement using Kalman Filter

The quality and intelligibility of speech conversation are generally degraded by the surrounding noises. The main objective of speech enhancement (SE) is to eliminate or reduce such disturbing noises from the degraded speech. Various SE methods have been proposed in literature. Among them, the Kalman filter (KF) is known to be an efficient SE method that uses the minimum mean square error (MMSE). However, most of the conventional KF based speech enhancement methods need access to clean speech and additive noise information for the state-space model parameters, namely, the linear prediction coefficients (LPCs) and the additive noise variance estimation, which is impractical in the sense that in practice, we can access only the noisy speech. Moreover, it is quite difficult to estimate these model parameters efficiently in the presence of adverse environmental noises. Therefore, the main focus of this thesis is to develop single channel speech enhancement algorithms using Kalman filter, where the model parameters are estimated in noisy conditions. Depending on these parameter estimation techniques, the proposed SE methods are classified into three approaches based on non-iterative, iterative, and sub-band iterative KF. In the first approach, a non-iterative Kalman filter based speech enhancement algorithm is presented, which operates on a frame-by-frame basis. In this proposed method, the state-space model parameters, namely, the LPCs and noise variance, are estimated first in noisy conditions. For LPC estimation, a combined speech smoothing and autocorrelation method is employed. A new method based on a lower-order truncated Taylor series approximation of the noisy speech along with a difference operation serving as high-pass filtering is introduced for the noise variance estimation. The non-iterative Kalman filter is then implemented with these estimated parameters effectively. In order to enhance the SE performance as well as parameter estimation accuracy in noisy conditions, an iterative Kalman filter based single channel SE method is proposed as the second approach, which also operates on a frame-by-frame basis. For each frame, the state-space model parameters of the KF are estimated through an iterative procedure. The Kalman filtering iteration is first applied to each noisy speech frame, reducing the noise component to a certain degree. At the end of this first iteration, the LPCs and other state-space model parameters are re-estimated using the processed speech frame and the Kalman filtering is repeated for the same processed frame. This iteration continues till the KF converges or a maximum number of iterations is reached, giving further enhanced speech frame. The same procedure will repeat for the following frames until the last noisy speech frame being processed. For further improving the speech enhancement performance, a sub-band iterative Kalman filter based SE method is also proposed as the third approach. A wavelet filter-bank is first used to decompose the noisy speech into a number of sub-bands. To achieve the best trade-off among the noise reduction, speech intelligibility and computational complexity, a partial reconstruction scheme based on consecutive mean squared error (CMSE) is proposed to synthesize the low-frequency (LF) and highfrequency (HF) sub-bands such that the iterative KF is employed only to the partially reconstructed HF sub-band speech. Finally, the enhanced HF sub-band speech is combined with the partially reconstructed LF sub-band speech to reconstruct the full-band enhanced speech. Experimental results have shown that the proposed KF based SE methods are capable of reducing adverse environmental noises for a wide range of input SNRs, and the overall performance of the proposed methods in terms of different evaluation metrics is superior to some existing state-of-the art SE methods

Dirty RF Signal Processing for Mitigation of Receiver Front-end Non-linearity

Moderne drahtlose Kommunikationssysteme stellen hohe und teilweise gegensätzliche Anforderungen an die Hardware der Funkmodule, wie z.B. niedriger Energieverbrauch, große Bandbreite und hohe Linearität. Die Gewährleistung einer ausreichenden Linearität ist, neben anderen analogen Parametern, eine Herausforderung im praktischen Design der Funkmodule. Der Fokus der Dissertation liegt auf breitbandigen HF-Frontends für Software-konfigurierbare Funkmodule, die seit einigen Jahren kommerziell verfügbar sind. Die praktischen Herausforderungen und Grenzen solcher flexiblen Funkmodule offenbaren sich vor allem im realen Experiment. Eines der Hauptprobleme ist die Sicherstellung einer ausreichenden analogen Performanz über einen weiten Frequenzbereich. Aus einer Vielzahl an analogen Störeffekten behandelt die Arbeit die Analyse und Minderung von Nichtlinearitäten in Empfängern mit direkt-umsetzender Architektur. Im Vordergrund stehen dabei Signalverarbeitungsstrategien zur Minderung nichtlinear verursachter Interferenz - ein Algorithmus, der besser unter "Dirty RF"-Techniken bekannt ist. Ein digitales Verfahren nach der Vorwärtskopplung wird durch intensive Simulationen, Messungen und Implementierung in realer Hardware verifiziert. Um die Lücken zwischen Theorie und praktischer Anwendbarkeit zu schließen und das Verfahren in reale Funkmodule zu integrieren, werden verschiedene Untersuchungen durchgeführt. Hierzu wird ein erweitertes Verhaltensmodell entwickelt, das die Struktur direkt-umsetzender Empfänger am besten nachbildet und damit alle Verzerrungen im HF- und Basisband erfasst. Darüber hinaus wird die Leistungsfähigkeit des Algorithmus unter realen Funkkanal-Bedingungen untersucht. Zusätzlich folgt die Vorstellung einer ressourceneffizienten Echtzeit-Implementierung des Verfahrens auf einem FPGA. Abschließend diskutiert die Arbeit verschiedene Anwendungsfelder, darunter spektrales Sensing, robuster GSM-Empfang und GSM-basiertes Passivradar. Es wird gezeigt, dass nichtlineare Verzerrungen erfolgreich in der digitalen Domäne gemindert werden können, wodurch die Bitfehlerrate gestörter modulierter Signale sinkt und der Anteil nichtlinear verursachter Interferenz minimiert wird. Schließlich kann durch das Verfahren die effektive Linearität des HF-Frontends stark erhöht werden. Damit wird der zuverlässige Betrieb eines einfachen Funkmoduls unter dem Einfluss der Empfängernichtlinearität möglich. Aufgrund des flexiblen Designs ist der Algorithmus für breitbandige Empfänger universal einsetzbar und ist nicht auf Software-konfigurierbare Funkmodule beschränkt.Today's wireless communication systems place high requirements on the radio's hardware that are largely mutually exclusive, such as low power consumption, wide bandwidth, and high linearity. Achieving a sufficient linearity, among other analogue characteristics, is a challenging issue in practical transceiver design. The focus of this thesis is on wideband receiver RF front-ends for software defined radio technology, which became commercially available in the recent years. Practical challenges and limitations are being revealed in real-world experiments with these radios. One of the main problems is to ensure a sufficient RF performance of the front-end over a wide bandwidth. The thesis covers the analysis and mitigation of receiver non-linearity of typical direct-conversion receiver architectures, among other RF impairments. The main focus is on DSP-based algorithms for mitigating non-linearly induced interference, an approach also known as "Dirty RF" signal processing techniques. The conceived digital feedforward mitigation algorithm is verified through extensive simulations, RF measurements, and implementation in real hardware. Various studies are carried out that bridge the gap between theory and practical applicability of this approach, especially with the aim of integrating that technique into real devices. To this end, an advanced baseband behavioural model is developed that matches to direct-conversion receiver architectures as close as possible, and thus considers all generated distortions at RF and baseband. In addition, the algorithm's performance is verified under challenging fading conditions. Moreover, the thesis presents a resource-efficient real-time implementation of the proposed solution on an FPGA. Finally, different use cases are covered in the thesis that includes spectrum monitoring or sensing, GSM downlink reception, and GSM-based passive radar. It is shown that non-linear distortions can be successfully mitigated at system level in the digital domain, thereby decreasing the bit error rate of distorted modulated signals and reducing the amount of non-linearly induced interference. Finally, the effective linearity of the front-end is increased substantially. Thus, the proper operation of a low-cost radio under presence of receiver non-linearity is possible. Due to the flexible design, the algorithm is generally applicable for wideband receivers and is not restricted to software defined radios

Time-frequency analysis based on split spectrum applied to audio and ultrasonic signals

This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonSignal processing is a large subject with applications integral to a number of technological fields such as communication, audio, Voice over IP (VoIP), pattern recognition, sonar, radar, ultrasound and medical imaging. Techniques exist for the analysis, modelling, extraction, recognition and synthesis of signals of interest. The focus of this thesis is signal processing for acoustics (both sonic and ultrasonic). In the applications examined, signals of interest are usually incomplete, distorted and/or noisy. Therefore, reconstructing the signal, noise reduction and removal of any distortion/interference are the main goals of the signal processing techniques presented. The primary aim is to study and develop an advanced time-frequency signal processing technique for acoustic applications to enhance the quality of the signals. In the first part of the thesis, a technique is presented that models and maintains the correlation between temporal and spectral parameters of audio signals. A novel Packet Loss Concealment (PLC) method is developed with applications to VoIP, audio broadcasting, and streaming. The problem of modelling the time-varying frequency spectrum in the context of PLC is addressed, and a novel solution is proposed for tracking and using the temporal motion of spectral flow to reconstruct the signal. The proposed method utilises a Time-Frequency Motion (TFM) matrix representation of the audio signal, where each frequency is tagged with a motion vector estimate that is assessed by cross-correlation of the movement of spectral energy within sub-bands across time frames. The missing packets are estimated using extrapolation or interpolation algorithms using a TFM matrix and then inverse transformed to the time-domain for reconstruction of the signal. The proposed method is compared with conventional approaches using objective Performance Evaluation of Speech Quality (PESQ), and subjective Mean Opinion Scores (MOS) in a range of packet loss from 5% to 20%. The evaluation results demonstrate that the proposed algorithm substantially improves performance by an average of 2.85% and 5.9% in terms of PESQ and MOS respectively. In the second part of the thesis, the proposed method is extended and modified to address challenges of excessive coherent noise arising from ultrasonic signals gathered during Guided Wave Testing (GWT). It is an advanced Non-destructive testing technique which is used over several branches of industry to inspect large structures for defects where the structural integrity is of concern. In such systems, signal interpretation can often be challenging due to the multi-modal and dispersive propagation of Ultrasonic Guided Waves (UGWs). The multi-modal and dispersive nature of the received signals hampers the ability to detect defects in a given structure. The Split-Spectrum Processing (SSP) method with application for such signal has been studied and reviewed quantitatively to measure the enhancement in terms of Signal-to-Noise Ratio (SNR) and spatial resolution. In this thesis, the influence of SSP filter bank parameters on these signals is studied and optimised to improve SNR and spatial resolution considerably. The proposed method is compared analytically and experimentally with conventional approaches. The proposed SSP algorithm substantially improves SNR by an average of 30dB. The conclusions reached in this thesis will contribute to the progression of the GWT technique through considerable improvement in defect detection capability.Centre for Electronic Systems Research (CESR) of Brunel University London, The National Structural Integrity Research Centre (NSIRC) and TWI Ltd

Speech Enhancement Exploiting the Source-Filter Model

Imagining everyday life without mobile telephony is nowadays hardly possible. Calls are being made in every thinkable situation and environment. Hence, the microphone will not only pick up the user’s speech but also sound from the surroundings which is likely to impede the understanding of the conversational partner. Modern speech enhancement systems are able to mitigate such effects and most users are not even aware of their existence. In this thesis the development of a modern single-channel speech enhancement approach is presented, which uses the divide and conquer principle to combat environmental noise in microphone signals. Though initially motivated by mobile telephony applications, this approach can be applied whenever speech is to be retrieved from a corrupted signal. The approach uses the so-called source-filter model to divide the problem into two subproblems which are then subsequently conquered by enhancing the source (the excitation signal) and the filter (the spectral envelope) separately. Both enhanced signals are then used to denoise the corrupted signal. The estimation of spectral envelopes has quite some history and some approaches already exist for speech enhancement. However, they typically neglect the excitation signal which leads to the inability of enhancing the fine structure properly. Both individual enhancement approaches exploit benefits of the cepstral domain which offers, e.g., advantageous mathematical properties and straightforward synthesis of excitation-like signals. We investigate traditional model-based schemes like Gaussian mixture models (GMMs), classical signal processing-based, as well as modern deep neural network (DNN)-based approaches in this thesis. The enhanced signals are not used directly to enhance the corrupted signal (e.g., to synthesize a clean speech signal) but as so-called a priori signal-to-noise ratio (SNR) estimate in a traditional statistical speech enhancement system. Such a traditional system consists of a noise power estimator, an a priori SNR estimator, and a spectral weighting rule that is usually driven by the results of the aforementioned estimators and subsequently employed to retrieve the clean speech estimate from the noisy observation. As a result the new approach obtains significantly higher noise attenuation compared to current state-of-the-art systems while maintaining a quite comparable speech component quality and speech intelligibility. In consequence, the overall quality of the enhanced speech signal turns out to be superior as compared to state-of-the-art speech ehnahcement approaches.Mobiltelefonie ist aus dem heutigen Leben nicht mehr wegzudenken. Telefonate werden in beliebigen Situationen an beliebigen Orten geführt und dabei nimmt das Mikrofon nicht nur die Sprache des Nutzers auf, sondern auch die Umgebungsgeräusche, welche das Verständnis des Gesprächspartners stark beeinflussen können. Moderne Systeme können durch Sprachverbesserungsalgorithmen solchen Effekten entgegenwirken, dabei ist vielen Nutzern nicht einmal bewusst, dass diese Algorithmen existieren. In dieser Arbeit wird die Entwicklung eines einkanaligen Sprachverbesserungssystems vorgestellt. Der Ansatz setzt auf das Teile-und-herrsche-Verfahren, um störende Umgebungsgeräusche aus Mikrofonsignalen herauszufiltern. Dieses Verfahren kann für sämtliche Fälle angewendet werden, in denen Sprache aus verrauschten Signalen extrahiert werden soll. Der Ansatz nutzt das Quelle-Filter-Modell, um das ursprüngliche Problem in zwei Unterprobleme aufzuteilen, die anschließend gelöst werden, indem die Quelle (das Anregungssignal) und das Filter (die spektrale Einhüllende) separat verbessert werden. Die verbesserten Signale werden gemeinsam genutzt, um das gestörte Mikrofonsignal zu entrauschen. Die Schätzung von spektralen Einhüllenden wurde bereits in der Vergangenheit erforscht und zum Teil auch für die Sprachverbesserung angewandt. Typischerweise wird dabei jedoch das Anregungssignal vernachlässigt, so dass die spektrale Feinstruktur des Mikrofonsignals nicht verbessert werden kann. Beide Ansätze nutzen jeweils die Eigenschaften der cepstralen Domäne, die unter anderem vorteilhafte mathematische Eigenschaften mit sich bringen, sowie die Möglichkeit, Prototypen eines Anregungssignals zu erzeugen. Wir untersuchen modellbasierte Ansätze, wie z.B. Gaußsche Mischmodelle, klassische signalverarbeitungsbasierte Lösungen und auch moderne tiefe neuronale Netzwerke in dieser Arbeit. Die so verbesserten Signale werden nicht direkt zur Sprachsignalverbesserung genutzt (z.B. Sprachsynthese), sondern als sogenannter A-priori-Signal-zu-Rauschleistungs-Schätzwert in einem traditionellen statistischen Sprachverbesserungssystem. Dieses besteht aus einem Störleistungs-Schätzer, einem A-priori-Signal-zu-Rauschleistungs-Schätzer und einer spektralen Gewichtungsregel, die üblicherweise mit Hilfe der Ergebnisse der beiden Schätzer berechnet wird. Schließlich wird eine Schätzung des sauberen Sprachsignals aus der Mikrofonaufnahme gewonnen. Der neue Ansatz bietet eine signifikant höhere Dämpfung des Störgeräuschs als der bisherige Stand der Technik. Dabei wird eine vergleichbare Qualität der Sprachkomponente und der Sprachverständlichkeit gewährleistet. Somit konnte die Gesamtqualität des verbesserten Sprachsignals gegenüber dem Stand der Technik erhöht werden

Models and analysis of vocal emissions for biomedical applications

This book of Proceedings collects the papers presented at the 3rd International Workshop on Models and Analysis of Vocal Emissions for Biomedical Applications, MAVEBA 2003, held 10-12 December 2003, Firenze, Italy. The workshop is organised every two years, and aims to stimulate contacts between specialists active in research and industrial developments, in the area of voice analysis for biomedical applications. The scope of the Workshop includes all aspects of voice modelling and analysis, ranging from fundamental research to all kinds of biomedical applications and related established and advanced technologies

Modeling and Digital Mitigation of Transmitter Imperfections in Radio Communication Systems

To satisfy the continuously growing demands for higher data rates, modern radio communication systems employ larger bandwidths and more complex waveforms. Furthermore, radio devices are expected to support a rich mixture of standards such as cellular networks, wireless local-area networks, wireless personal area networks, positioning and navigation systems, etc. In general, a "smart'' device should be flexible to support all these requirements while being portable, cheap, and energy efficient. These seemingly conflicting expectations impose stringent radio frequency (RF) design challenges which, in turn, call for their proper understanding as well as developing cost-effective solutions to address them. The direct-conversion transceiver architecture is an appealing analog front-end for flexible and multi-standard radio systems. However, it is sensitive to various circuit impairments, and modern communication systems based on multi-carrier waveforms such as Orthogonal Frequency Division Multiplexing (OFDM) and Orthogonal Frequency Division Multiple Access (OFDMA) are particularly vulnerable to RF front-end non-idealities.This thesis addresses the modeling and digital mitigation of selected transmitter (TX) RF impairments in radio communication devices. The contributions can be divided into two areas. First, new modeling and digital mitigation techniques are proposed for two essential front-end impairments in direct-conversion architecture-based OFDM and OFDMA systems, namely inphase and quadrature phase (I/Q) imbalance and carrier frequency offset (CFO). Both joint and de-coupled estimation and compensation schemes for frequency-selective TX I/Q imbalance and channel distortions are proposed for OFDM systems, to be adopted on the receiver side. Then, in the context of uplink OFDMA and Single Carrier FDMA (SC-FDMA), which are the air interface technologies of the 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) and LTE-Advanced systems, joint estimation and equalization techniques of RF impairments and channel distortions are proposed. Here, the challenging multi-user uplink scenario with unequal received power levels is investigated where I/Q imbalance causes inter-user interference. A joint mirror subcarrier processing-based minimum mean-square error (MMSE) equalizer with an arbitrary number of receiver antennas is formulated to effectively handle the mirror sub-band users of different power levels. Furthermore, the joint channel and impairments filter responses are efficiently approximated with polynomial-based basis function models, and the parameters of basis functions are estimated with the reference signals conforming to the LTE uplink sub-frame structure. The resulting receiver concept adopting the proposed techniques enables improved link performance without modifying the design of RF transceivers.Second, digital baseband mitigation solutions are developed for the TX leakage signal-induced self-interference in frequency division duplex (FDD) transceivers. In FDD transceivers, a duplexer is used to connect the TX and receiver (RX) chains to a common antenna while also providing isolation to the receiver chain against the powerful transmit signal. In general, the continuous miniaturization of hardware and adoption of larger bandwidths through carrier aggregation type noncontiguous allocations complicates achieving sufficient TX-RX isolation. Here, two different effects of the transmitter leakage signal are investigated. The first is TX out-of-band (OOB) emissions and TX spurious emissions at own receiver band, due to the transmitter nonlinearity, and the second is nonlinearity of down-converter in the RX that generates second-order intermodulation distortion (IMD2) due to the TX in-band leakage signal. This work shows that the transmitter leakage signal-induced interference depends on an equivalent leakage channel that models the TX path non-idealities, duplexer filter responses, and the RX path non-idealities. The work proposes algorithms that operate in the digital baseband of the transceiver to estimate the TX-RX non-idealities and the duplexer filter responses, and subsequently regenerating and canceling the self-interference, thereby potentially relaxing the TX-RX isolation requirements as well as increasing the transceiver flexibility.Overall, this thesis provides useful signal models to understand the implications of different RF non-idealities and proposes compensation solutions to cope with certain RF impairments. This is complemented with extensive computer simulations and practical RF measurements to validate their application in real-world radio transceivers

Speech coding at medium bit rates using analysis by synthesis techniques

Speech coding at medium bit rates using analysis by synthesis technique

The development of speech coding and the first standard coder for public mobile telephony

This thesis describes in its core chapter (Chapter 4) the original algorithmic and design features of the ??rst coder for public mobile telephony, the GSM full-rate speech coder, as standardized in 1988. It has never been described in so much detail as presented here. The coder is put in a historical perspective by two preceding chapters on the history of speech production models and the development of speech coding techniques until the mid 1980s, respectively. In the epilogue a brief review is given of later developments in speech coding. The introductory Chapter 1 starts with some preliminaries. It is de- ??ned what speech coding is and the reader is introduced to speech coding standards and the standardization institutes which set them. Then, the attributes of a speech coder playing a role in standardization are explained. Subsequently, several applications of speech coders - including mobile telephony - will be discussed and the state of the art in speech coding will be illustrated on the basis of some worldwide recognized standards. Chapter 2 starts with a summary of the features of speech signals and their source, the human speech organ. Then, historical models of speech production which form the basis of di??erent kinds of modern speech coders are discussed. Starting with a review of ancient mechanical models, we will arrive at the electrical source-??lter model of the 1930s. Subsequently, the acoustic-tube models as they arose in the 1950s and 1960s are discussed. Finally the 1970s are reviewed which brought the discrete-time ??lter model on the basis of linear prediction. In a unique way the logical sequencing of these models is exposed, and the links are discussed. Whereas the historical models are discussed in a narrative style, the acoustic tube models and the linear prediction tech nique as applied to speech, are subject to more mathematical analysis in order to create a sound basis for the treatise of Chapter 4. This trend continues in Chapter 3, whenever instrumental in completing that basis. In Chapter 3 the reader is taken by the hand on a guided tour through time during which successive speech coding methods pass in review. In an original way special attention is paid to the evolutionary aspect. Speci??cally, for each newly proposed method it is discussed what it added to the known techniques of the time. After presenting the relevant predecessors starting with Pulse Code Modulation (PCM) and the early vocoders of the 1930s, we will arrive at Residual-Excited Linear Predictive (RELP) coders, Analysis-by-Synthesis systems and Regular- Pulse Excitation in 1984. The latter forms the basis of the GSM full-rate coder. In Chapter 4, which constitutes the core of this thesis, explicit forms of Multi-Pulse Excited (MPE) and Regular-Pulse Excited (RPE) analysis-by-synthesis coding systems are developed. Starting from current pulse-amplitude computation methods in 1984, which included solving sets of equations (typically of order 10-16) two hundred times a second, several explicit-form designs are considered by which solving sets of equations in real time is avoided. Then, the design of a speci??c explicitform RPE coder and an associated eÆcient architecture are described. The explicit forms and the resulting architectural features have never been published in so much detail as presented here. Implementation of such a codec enabled real-time operation on a state-of-the-art singlechip digital signal processor of the time. This coder, at a bit rate of 13 kbit/s, has been selected as the Full-Rate GSM standard in 1988. Its performance is recapitulated. Chapter 5 is an epilogue brie y reviewing the major developments in speech coding technology after 1988. Many speech coding standards have been set, for mobile telephony as well as for other applications, since then. The chapter is concluded by an outlook