22,000 research outputs found
MOLNs: A cloud platform for interactive, reproducible and scalable spatial stochastic computational experiments in systems biology using PyURDME
Computational experiments using spatial stochastic simulations have led to
important new biological insights, but they require specialized tools, a
complex software stack, as well as large and scalable compute and data analysis
resources due to the large computational cost associated with Monte Carlo
computational workflows. The complexity of setting up and managing a
large-scale distributed computation environment to support productive and
reproducible modeling can be prohibitive for practitioners in systems biology.
This results in a barrier to the adoption of spatial stochastic simulation
tools, effectively limiting the type of biological questions addressed by
quantitative modeling. In this paper, we present PyURDME, a new, user-friendly
spatial modeling and simulation package, and MOLNs, a cloud computing appliance
for distributed simulation of stochastic reaction-diffusion models. MOLNs is
based on IPython and provides an interactive programming platform for
development of sharable and reproducible distributed parallel computational
experiments
A Rewriting-Logic-Based Technique for Modeling Thermal Systems
This paper presents a rewriting-logic-based modeling and analysis technique
for physical systems, with focus on thermal systems. The contributions of this
paper can be summarized as follows: (i) providing a framework for modeling and
executing physical systems, where both the physical components and their
physical interactions are treated as first-class citizens; (ii) showing how
heat transfer problems in thermal systems can be modeled in Real-Time Maude;
(iii) giving the implementation in Real-Time Maude of a basic numerical
technique for executing continuous behaviors in object-oriented hybrid systems;
and (iv) illustrating these techniques with a set of incremental case studies
using realistic physical parameters, with examples of simulation and model
checking analyses.Comment: In Proceedings RTRTS 2010, arXiv:1009.398
Viewpoint Development of Stochastic Hybrid Systems
Nowadays, due to the explosive spreading of networked and highly distributed systems, mastering system complexity becomes a critical issue. Two development and verification paradigms have become more popular: viewpoints and randomisation. The viewpoints offer large freedom and introduce concurrency and compositionality in the development process. Randomisation is now a traditional method for reducing complexity (comparing with deterministic models) and it offers finer analytical analysis tools (quantification over non-determinism, multi-valued logics, etc). In this paper, we propose a combination of these two paradigms introducing a viewpoint methodology for systems with stochastic behaviours
Simulation of networks of spiking neurons: A review of tools and strategies
We review different aspects of the simulation of spiking neural networks. We
start by reviewing the different types of simulation strategies and algorithms
that are currently implemented. We next review the precision of those
simulation strategies, in particular in cases where plasticity depends on the
exact timing of the spikes. We overview different simulators and simulation
environments presently available (restricted to those freely available, open
source and documented). For each simulation tool, its advantages and pitfalls
are reviewed, with an aim to allow the reader to identify which simulator is
appropriate for a given task. Finally, we provide a series of benchmark
simulations of different types of networks of spiking neurons, including
Hodgkin-Huxley type, integrate-and-fire models, interacting with current-based
or conductance-based synapses, using clock-driven or event-driven integration
strategies. The same set of models are implemented on the different simulators,
and the codes are made available. The ultimate goal of this review is to
provide a resource to facilitate identifying the appropriate integration
strategy and simulation tool to use for a given modeling problem related to
spiking neural networks.Comment: 49 pages, 24 figures, 1 table; review article, Journal of
Computational Neuroscience, in press (2007
Generating a Performance Stochastic Model from UML Specifications
Since its initiation by Connie Smith, the process of Software Performance
Engineering (SPE) is becoming a growing concern. The idea is to bring
performance evaluation into the software design process. This suitable
methodology allows software designers to determine the performance of software
during design. Several approaches have been proposed to provide such
techniques. Some of them propose to derive from a UML (Unified Modeling
Language) model a performance model such as Stochastic Petri Net (SPN) or
Stochastic process Algebra (SPA) models. Our work belongs to the same category.
We propose to derive from a UML model a Stochastic Automata Network (SAN) in
order to obtain performance predictions. Our approach is more flexible due to
the SAN modularity and its high resemblance to UML' state-chart diagram
Scalable Approach to Uncertainty Quantification and Robust Design of Interconnected Dynamical Systems
Development of robust dynamical systems and networks such as autonomous
aircraft systems capable of accomplishing complex missions faces challenges due
to the dynamically evolving uncertainties coming from model uncertainties,
necessity to operate in a hostile cluttered urban environment, and the
distributed and dynamic nature of the communication and computation resources.
Model-based robust design is difficult because of the complexity of the hybrid
dynamic models including continuous vehicle dynamics, the discrete models of
computations and communications, and the size of the problem. We will overview
recent advances in methodology and tools to model, analyze, and design robust
autonomous aerospace systems operating in uncertain environment, with stress on
efficient uncertainty quantification and robust design using the case studies
of the mission including model-based target tracking and search, and trajectory
planning in uncertain urban environment. To show that the methodology is
generally applicable to uncertain dynamical systems, we will also show examples
of application of the new methods to efficient uncertainty quantification of
energy usage in buildings, and stability assessment of interconnected power
networks
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