The Novel Approach of Adaptive Twin Probability for Genetic Algorithm

The performance of GA is measured and analyzed in terms of its performance parameters against variations in its genetic operators and associated parameters. Since last four decades huge numbers of researchers have been working on the performance of GA and its enhancement. This earlier research work on analyzing the performance of GA enforces the need to further investigate the exploration and exploitation characteristics and observe its impact on the behavior and overall performance of GA. This paper introduces the novel approach of adaptive twin probability associated with the advanced twin operator that enhances the performance of GA. The design of the advanced twin operator is extrapolated from the twin offspring birth due to single ovulation in natural genetic systems as mentioned in the earlier works. The twin probability of this operator is adaptively varied based on the fitness of best individual thereby relieving the GA user from statically defining its value. This novel approach of adaptive twin probability is experimented and tested on the standard benchmark optimization test functions. The experimental results show the increased accuracy in terms of the best individual and reduced convergence time.Comment: 7 pages, International Journal of Advanced Studies in Computer Science and Engineering (IJASCSE), Volume 2, Special Issue 2, 201

Compressed Genotyping

Significant volumes of knowledge have been accumulated in recent years linking subtle genetic variations to a wide variety of medical disorders from Cystic Fibrosis to mental retardation. Nevertheless, there are still great challenges in applying this knowledge routinely in the clinic, largely due to the relatively tedious and expensive process of DNA sequencing. Since the genetic polymorphisms that underlie these disorders are relatively rare in the human population, the presence or absence of a disease-linked polymorphism can be thought of as a sparse signal. Using methods and ideas from compressed sensing and group testing, we have developed a cost-effective genotyping protocol. In particular, we have adapted our scheme to a recently developed class of high throughput DNA sequencing technologies, and assembled a mathematical framework that has some important distinctions from 'traditional' compressed sensing ideas in order to address different biological and technical constraints.Comment: Submitted to IEEE Transaction on Information Theory - Special Issue on Molecular Biology and Neuroscienc

FairFuzz: Targeting Rare Branches to Rapidly Increase Greybox Fuzz Testing Coverage

In recent years, fuzz testing has proven itself to be one of the most effective techniques for finding correctness bugs and security vulnerabilities in practice. One particular fuzz testing tool, American Fuzzy Lop or AFL, has become popular thanks to its ease-of-use and bug-finding power. However, AFL remains limited in the depth of program coverage it achieves, in particular because it does not consider which parts of program inputs should not be mutated in order to maintain deep program coverage. We propose an approach, FairFuzz, that helps alleviate this limitation in two key steps. First, FairFuzz automatically prioritizes inputs exercising rare parts of the program under test. Second, it automatically adjusts the mutation of inputs so that the mutated inputs are more likely to exercise these same rare parts of the program. We conduct evaluation on real-world programs against state-of-the-art versions of AFL, thoroughly repeating experiments to get good measures of variability. We find that on certain benchmarks FairFuzz shows significant coverage increases after 24 hours compared to state-of-the-art versions of AFL, while on others it achieves high program coverage at a significantly faster rate

Robustness-Driven Resilience Evaluation of Self-Adaptive Software Systems

An increasingly important requirement for certain classes of software-intensive systems is the ability to self-adapt their structure and behavior at run-time when reacting to changes that may occur to the system, its environment, or its goals. A major challenge related to self-adaptive software systems is the ability to provide assurances of their resilience when facing changes. Since in these systems, the components that act as controllers of a target system incorporate highly complex software, there is the need to analyze the impact that controller failures might have on the services delivered by the system. In this paper, we present a novel approach for evaluating the resilience of self-adaptive software systems by applying robustness testing techniques to the controller to uncover failures that can affect system resilience. The approach for evaluating resilience, which is based on probabilistic model checking, quantifies the probability of satisfaction of system properties when the target system is subject to controller failures. The feasibility of the proposed approach is evaluated in the context of an industrial middleware system used to monitor and manage highly populated networks of devices, which was implemented using the Rainbow framework for architecture-based self-adaptation

New insight into genetic disease : the role of trinucleotide repeat expansions

The development of genetics in the last few decades is replete with surprise phenomena and new findings. One such phenomenon is the trinucleotide repeat expansion, a new type of mutation first discovered in 1991. These genetic diseases usually appear late in life and show the unusual phenomenon of anticipation in which the disease appears earlier and increases in severity in subsequent generations. In the present age of molecular genetics all physicians must be informed and educated about the implications of genetic diseases. Equally, there must be appropriate facilities for genetic testing and counselling and it is the responsibility of health authorities to ensure that such facilities are available and adequate.peer-reviewe

Web API Fragility: How Robust is Your Web API Client

Web APIs provide a systematic and extensible approach for application-to-application interaction. A large number of mobile applications makes use of web APIs to integrate services into apps. Each Web API's evolution pace is determined by their respective developer and mobile application developers are forced to accompany the API providers in their software evolution tasks. In this paper we investigate whether mobile application developers understand and how they deal with the added distress of web APIs evolving. In particular, we studied how robust 48 high profile mobile applications are when dealing with mutated web API responses. Additionally, we interviewed three mobile application developers to better understand their choices and trade-offs regarding web API integration.Comment: Technical repor

Attitudes Toward Breast Cancer Genetic Testing in Five Special Population Groups

Purpose: This study examined interest in and attitudes toward genetic testing in 5 different population groups. Methods: The survey included African American, Asian American, Latina, Native American, and Appalachian women with varying familial histories of breast cancer. A total of 49 women were interviewed in person. Descriptive and nonparametric statistical techniques were used to assess ethnic group differences. Results: Overall, interest in testing was high. All groups endorsed more benefits than risks. There were group differences regarding endorsement of specific benefits and risks: testing to “follow doctor recommendations” (p=0.017), “concern for effects on family” (p=0.044), “distrust of modern medicine” (p=0.036), “cost” (p=0.025), and “concerns about communication of results to others” (p=0.032). There was a significant inverse relationship between interest and genetic testing cost (p Conclusion: Cost may be an important barrier to obtaining genetic testing services, and participants would benefit by genetic counseling that incorporates the unique cultural values and beliefs of each group to create an individualized, culturally competent program. Further research about attitudes toward genetic testing is needed among Asian Americans, Native Americans, and Appalachians for whom data are severely lacking. Future study of the different Latina perceptions toward genetic testing are encouraged

Ethical issues connected with the privacy of persons found to have genetic defects

Information on genetic defects constitutes knowledge of a very intimate nature and can change a person’s life radically. Knowledge of one’s own genetic defects can be a source of great anxiety even if this information is kept secret. When the confidentiality of this information is broken the person is often placed in a very vulnerable position and his/her basic rights are threatened. Very serious harm can be done to the person involved. On the other hand, genetic information pertaining to one person can have serious implications for others’ welfare including spouses, children, and extended family members. How ought a genetic researcher/doctor deal with the information of genetic defects of his/her patients?peer-reviewe