Controlled vocabularies in bioinformatics: A case study in the Gene Ontology

The automatic integration of information resources in the life sciences is one of the most challenging goals facing biomedical informatics today. Controlled vocabularies have played an important role in realizing this goal, by making it possible to draw together information from heterogeneous sources secure in the knowledge that the same terms will also represent the same entities on all occasions of use. One of the most impressive achievements in this regard is the Gene Ontology (GO), which is rapidly acquiring the status of a de facto standard in the field of gene and gene product annotations, and whose methodology has been much intimated in attempts to develop controlled vocabularies for shared use in different domains of biology. The GO Consortium has recognized, however, that its controlled vocabulary as currently constituted is marked by several problematic features - features which are characteristic of much recent work in bioinformatics and which are destined to raise increasingly serious obstacles to the automatic integration of biomedical information in the future. Here, we survey some of these problematic features, focusing especially on issues of compositionality and syntactic regimentation

Evolving more efficient digital circuits by allowing circuit layout evolution and multi-objective fitness

We use evolutionary search to design combinational logic circuits. The technique is based on evolving the functionality and connectivity of a rectangular array of logic cells whose dimension is defined by the circuit layout. The main idea of this approach is to improve quality of the circuits evolved by the GA by reducing the number of active gates used. We accomplish this by combining two ideas: 1) using multi-objective fitness function; 2) evolving circuit layout. It will be shown that using these two approaches allows us to increase the quality of evolved circuits. The circuits are evolved in two phases. Initially the genome fitness in given by the percentage of output bits that are correct. Once 100% functional circuits have been evolved, the number of gates actually used in the circuit is taken into account in the fitness function. This allows us to evolve circuits with 100% functionality and minimise the number of active gates in circuit structure. The population is initialised with heterogeneous circuit layouts and the circuit layout is allowed to vary during the evolutionary process. Evolving the circuit layout together with the function is one of the distinctive features of proposed approach. The experimental results show that allowing the circuit layout to be flexible is useful when we want to evolve circuits with the smallest number of gates used. We find that it is better to use a fixed circuit layout when the objective is to achieve the highest number of 100% functional circuits. The two-fitness strategy is most effective when we allow a large number of generations

An Architecture-Altering and Training Methodology for Neural Logic Networks: Application in the Banking Sector

Artificial neural networks have been universally acknowledged for their ability on constructing forecasting and classifying systems. Among their desirable features, it has always been the interpretation of their structure, aiming to provide further knowledge for the domain experts. A number of methodologies have been developed for this reason. One such paradigm is the neural logic networks concept. Neural logic networks have been especially designed in order to enable the interpretation of their structure into a number of simple logical rules and they can be seen as a network representation of a logical rule base. Although powerful by their definition in this context, neural logic networks have performed poorly when used in approaches that required training from data. Standard training methods, such as the back-propagation, require the network’s synapse weight altering, which destroys the network’s interpretability. The methodology in this paper overcomes these problems and proposes an architecture-altering technique, which enables the production of highly antagonistic solutions while preserving any weight-related information. The implementation involves genetic programming using a grammar-guided training approach, in order to provide arbitrarily large and connected neural logic networks. The methodology is tested in a problem from the banking sector with encouraging results

Modular modelling of signalling pathways and their crosstalk

Signalling pathways are well-known abstractions that explain the mechanisms whereby cells respond to signals. Collections of pathways form networks, and interactions between pathways in a network, known as cross-talk, enables further complex signalling behaviours. While there are several formal modelling approaches for signalling pathways, none make cross-talk explicit; the aim of this paper is to define and categorise cross-talk in a rigorous way. We define a modular approach to pathway and network modelling, based on the module construct in the PRISM modelling language, and a set of generic signalling modules. Five different types of cross-talk are defined according to various biologically meaningful combinations of variable sharing, synchronisation labels and reaction renaming. The approach is illustrated with a case-study analysis of cross-talk between the TGF-β, WNT and MAPK pathways

Genetic Programming for Smart Phone Personalisation

Personalisation in smart phones requires adaptability to dynamic context based on user mobility, application usage and sensor inputs. Current personalisation approaches, which rely on static logic that is developed a priori, do not provide sufficient adaptability to dynamic and unexpected context. This paper proposes genetic programming (GP), which can evolve program logic in realtime, as an online learning method to deal with the highly dynamic context in smart phone personalisation. We introduce the concept of collaborative smart phone personalisation through the GP Island Model, in order to exploit shared context among co-located phone users and reduce convergence time. We implement these concepts on real smartphones to demonstrate the capability of personalisation through GP and to explore the benefits of the Island Model. Our empirical evaluations on two example applications confirm that the Island Model can reduce convergence time by up to two-thirds over standalone GP personalisation.Comment: 43 pages, 11 figure

A Survey on Continuous Time Computations

We provide an overview of theories of continuous time computation. These theories allow us to understand both the hardness of questions related to continuous time dynamical systems and the computational power of continuous time analog models. We survey the existing models, summarizing results, and point to relevant references in the literature