Chemical Similarity and Threshold of Toxicological Concern (TTC) Approaches: Report of an ECB Workshop held in Ispra, November 2005

There are many national, regional and international programmes – either regulatory or voluntary – to assess the hazards or risks of chemical substances to humans and the environment. The first step in making a hazard assessment of a chemical is to ensure that there is adequate information on each of the endpoints. If adequate information is not available then additional data is needed to complete the dataset for this substance. For reasons of resources and animal welfare, it is important to limit the number of tests that have to be conducted, where this is scientifically justifiable. One approach is to consider closely related chemicals as a group, or chemical category, rather than as individual chemicals. In a category approach, data for chemicals and endpoints that have been already tested are used to estimate the hazard for untested chemicals and endpoints. Categories of chemicals are selected on the basis of similarities in biological activity which is associated with a common underlying mechanism of action. A homologous series of chemicals exhibiting a coherent trend in biological activity can be rationalised on the basis of a constant change in structure. This type of grouping is relatively straightforward. The challenge lies in identifying the relevant chemical structural and physicochemical characteristics that enable more sophisticated groupings to be made on the basis of similarity in biological activity and hence purported mechanism of action. Linking two chemicals together and rationalising their similarity with reference to one or more endpoints has been very much carried out on an ad hoc basis. Even with larger groups, the process and approach is ad hoc and based on expert judgement. There still appears to be very little guidance about the tools and approaches for grouping chemicals systematically. In November 2005, the ECB Workshop on Chemical Similarity and Thresholds of Toxicological Concern (TTC) Approaches was convened to identify the available approaches that currently exist to encode similarity and how these can be used to facilitate the grouping of chemicals. This report aims to capture the main themes that were discussed. In particular, it outlines a number of different approaches that can facilitate the formation of chemical groupings in terms of the context under consideration and the likely information that would be required. Grouping methods were divided into one of four classes – knowledge-based, analogue-based, unsupervised, and supervised. A flowchart was constructed to attempt to capture a possible work flow to highlight where and how these approaches might be best applied.JRC.I.3-Toxicology and chemical substance

Text Extraction From Natural Scene: Methodology And Application

With the popularity of the Internet and the smart mobile device, there is an increasing demand for the techniques and applications of image/video-based analytics and information retrieval. Most of these applications can benefit from text information extraction in natural scene. However, scene text extraction is a challenging problem to be solved, due to cluttered background of natural scene and multiple patterns of scene text itself. To solve these problems, this dissertation proposes a framework of scene text extraction. Scene text extraction in our framework is divided into two components, detection and recognition. Scene text detection is to find out the regions containing text from camera captured images/videos. Text layout analysis based on gradient and color analysis is performed to extract candidates of text strings from cluttered background in natural scene. Then text structural analysis is performed to design effective text structural features for distinguishing text from non-text outliers among the candidates of text strings. Scene text recognition is to transform image-based text in detected regions into readable text codes. The most basic and significant step in text recognition is scene text character (STC) prediction, which is multi-class classification among a set of text character categories. We design robust and discriminative feature representations for STC structure, by integrating multiple feature descriptors, coding/pooling schemes, and learning models. Experimental results in benchmark datasets demonstrate the effectiveness and robustness of our proposed framework, which obtains better performance than previously published methods. Our proposed scene text extraction framework is applied to 4 scenarios, 1) reading print labels in grocery package for hand-held object recognition; 2) combining with car detection to localize license plate in camera captured natural scene image; 3) reading indicative signage for assistant navigation in indoor environments; and 4) combining with object tracking to perform scene text extraction in video-based natural scene. The proposed prototype systems and associated evaluation results show that our framework is able to solve the challenges in real applications

Geometrical-based algorithm for variational segmentation and smoothing of vector-valued images

An optimisation method based on a nonlinear functional is considered for segmentation and smoothing of vector-valued images. An edge-based approach is proposed to initially segment the image using geometrical properties such as metric tensor of the linearly smoothed image. The nonlinear functional is then minimised for each segmented region to yield the smoothed image. The functional is characterised with a unique solution in contrast with the Mumford–Shah functional for vector-valued images. An operator for edge detection is introduced as a result of this unique solution. This operator is analytically calculated and its detection performance and localisation are then compared with those of the DroGoperator. The implementations are applied on colour images as examples of vector-valued images, and the results demonstrate robust performance in noisy environments

From on-line sketching to 2D and 3D geometry: A fuzzy knowledge based system

The paper describes the development of a fuzzy knowledge based prototype system for conceptual design. This real time system is designed to infer user’s sketching intentions, to segment sketched input and generate corresponding geometric primitives: straight lines, circles, arcs, ellipses, elliptical arcs, and B-spline curves. Topology information (connectivity, unitary constraints and pairwise constraints) is received dynamically from 2D sketched input and primitives. From the 2D topology information, a more accurate 2D geometry can be built up by applying a 2D geometric constraint solver. Subsequently, 3D geometry can be received feature by feature incrementally. Each feature can be recognised by inference knowledge in terms of matching its 2D primitive configurations and connection relationships. The system accepts not only sketched input, working as an automatic design tools, but also accepts user’s interactive input of both 2D primitives and special positional 3D primitives. This makes it easy and friendly to use. The system has been tested with a number of sketched inputs of 2D and 3D geometry

The potential of additive manufacturing in the smart factory industrial 4.0: A review

Additive manufacturing (AM) or three-dimensional (3D) printing has introduced a novel production method in design, manufacturing, and distribution to end-users. This technology has provided great freedom in design for creating complex components, highly customizable products, and efficient waste minimization. The last industrial revolution, namely industry 4.0, employs the integration of smart manufacturing systems and developed information technologies. Accordingly, AM plays a principal role in industry 4.0 thanks to numerous benefits, such as time and material saving, rapid prototyping, high efficiency, and decentralized production methods. This review paper is to organize a comprehensive study on AM technology and present the latest achievements and industrial applications. Besides that, this paper investigates the sustainability dimensions of the AM process and the added values in economic, social, and environment sections. Finally, the paper concludes by pointing out the future trend of AM in technology, applications, and materials aspects that have the potential to come up with new ideas for the future of AM explorations

Real-time stress analysis of three-dimensional boundary element problems with continuously updating geometry

Computational design of mechanical components is an iterative process that involves multiple stress analysis runs; this can be time consuming and expensive. Significant improvements in the efficiency of this process can be made by increasing the level of interactivity. One approach is through real-time re-analysis of models with continuously updating geometry. In this work the boundary element method is used to realise this vision. Three primary areas need to be considered to accelerate the re-solution of boundary element problems. These are re-meshing the model, updating the boundary element system of equations and re-solution of the system. Once the initial model has been constructed and solved, the user may apply geometric perturbations to parts of the model. A new re-meshing algorithm accommodates these changes in geometry whilst retaining as much of the existing mesh as possible. This allows the majority of the previous boundary element system of equations to be re-used for the new analysis. Efficiency is achieved during re-integration by applying a reusable intrinsic sample point (RISP) integration scheme with a 64-bit single precision code. Parts of the boundary element system that have not been updated are retained by the re-analysis and integrals that multiply zero boundary conditions are suppressed. For models with fewer than 10,000 degrees of freedom, the re-integration algorithm performs up to five times faster than a standard integration scheme with less than 0.15% reduction in the L_2-norm accuracy of the solution vector. The method parallelises easily and an additional six times speed-up can be achieved on eight processors over the serial implementation. The performance of a range of direct, iterative and reduction based linear solvers have been compared for solving the boundary element system with the iterative generalised minimal residual (GMRES) solver providing the fastest convergence rate and the most accurate result. Further time savings are made by preconditioning the updated system with the LU decomposition of the original system. Using these techniques, near real-time analysis can be achieved for three-dimensional simulations; for two-dimensional models such real-time performance has already been demonstrated

Modeling of ground excavation with the particle finite element method

The present work introduces a new application of the Particle Finite Element Method (PFEM) for the modeling of excavation problems. PFEM is presented as a very suitable tool for the treatment of excavation problem. The method gives solution for the analysis of all processes that derive from it. The method has a high versatility and a reasonable computational cost. The obtained results are really promising.Postprint (published version