Spatial-temporal data modelling and processing for personalised decision support

The purpose of this research is to undertake the modelling of dynamic data without losing any of the temporal relationships, and to be able to predict likelihood of outcome as far in advance of actual occurrence as possible. To this end a novel computational architecture for personalised ( individualised) modelling of spatio-temporal data based on spiking neural network methods (PMeSNNr), with a three dimensional visualisation of relationships between variables is proposed. In brief, the architecture is able to transfer spatio-temporal data patterns from a multidimensional input stream into internal patterns in the spiking neural network reservoir. These patterns are then analysed to produce a personalised model for either classification or prediction dependent on the specific needs of the situation. The architecture described above was constructed using MatLab© in several individual modules linked together to form NeuCube (M1). This methodology has been applied to two real world case studies. Firstly, it has been applied to data for the prediction of stroke occurrences on an individual basis. Secondly, it has been applied to ecological data on aphid pest abundance prediction. Two main objectives for this research when judging outcomes of the modelling are accurate prediction and to have this at the earliest possible time point. The implications of these findings are not insignificant in terms of health care management and environmental control. As the case studies utilised here represent vastly different application fields, it reveals more of the potential and usefulness of NeuCube (M1) for modelling data in an integrated manner. This in turn can identify previously unknown (or less understood) interactions thus both increasing the level of reliance that can be placed on the model created, and enhancing our human understanding of the complexities of the world around us without the need for over simplification. Read less Keywords Personalised modelling; Spiking neural network; Spatial-temporal data modelling; Computational intelligence; Predictive modelling; Stroke risk predictio

Spatial-temporal data modelling and processing for personalised decision support

The purpose of this research is to undertake the modelling of dynamic data without losing any of the temporal relationships, and to be able to predict likelihood of outcome as far in advance of actual occurrence as possible. To this end a novel computational architecture for personalised ( individualised) modelling of spatio-temporal data based on spiking neural network methods (PMeSNNr), with a three dimensional visualisation of relationships between variables is proposed. In brief, the architecture is able to transfer spatio-temporal data patterns from a multidimensional input stream into internal patterns in the spiking neural network reservoir. These patterns are then analysed to produce a personalised model for either classification or prediction dependent on the specific needs of the situation. The architecture described above was constructed using MatLab© in several individual modules linked together to form NeuCube (M1). This methodology has been applied to two real world case studies. Firstly, it has been applied to data for the prediction of stroke occurrences on an individual basis. Secondly, it has been applied to ecological data on aphid pest abundance prediction. Two main objectives for this research when judging outcomes of the modelling are accurate prediction and to have this at the earliest possible time point. The implications of these findings are not insignificant in terms of health care management and environmental control. As the case studies utilised here represent vastly different application fields, it reveals more of the potential and usefulness of NeuCube (M1) for modelling data in an integrated manner. This in turn can identify previously unknown (or less understood) interactions thus both increasing the level of reliance that can be placed on the model created, and enhancing our human understanding of the complexities of the world around us without the need for over simplification. Read less Keywords Personalised modelling; Spiking neural network; Spatial-temporal data modelling; Computational intelligence; Predictive modelling; Stroke risk predictio

A hybrid CFGTSA based approach for scheduling problem: a case study of an automobile industry

In the global competitive world swift, reliable and cost effective production subject to uncertain situations, through an appropriate management of the available resources, has turned out to be the necessity for surviving in the market. This inspired the development of the more efficient and robust methods to counteract the existing complexities prevailing in the market. The present paper proposes a hybrid CFGTSA algorithm inheriting the salient features of GA, TS, SA, and chaotic theory to solve the complex scheduling problems commonly faced by most of the manufacturing industries. The proposed CFGTSA algorithm has been tested on a scheduling problem of an automobile industry, and its efficacy has been shown by comparing the results with GA, SA, TS, GTS, and hybrid TSA algorithms

On the use of biased-randomized algorithms for solving non-smooth optimization problems

Soft constraints are quite common in real-life applications. For example, in freight transportation, the fleet size can be enlarged by outsourcing part of the distribution service and some deliveries to customers can be postponed as well; in inventory management, it is possible to consider stock-outs generated by unexpected demands; and in manufacturing processes and project management, it is frequent that some deadlines cannot be met due to delays in critical steps of the supply chain. However, capacity-, size-, and time-related limitations are included in many optimization problems as hard constraints, while it would be usually more realistic to consider them as soft ones, i.e., they can be violated to some extent by incurring a penalty cost. Most of the times, this penalty cost will be nonlinear and even noncontinuous, which might transform the objective function into a non-smooth one. Despite its many practical applications, non-smooth optimization problems are quite challenging, especially when the underlying optimization problem is NP-hard in nature. In this paper, we propose the use of biased-randomized algorithms as an effective methodology to cope with NP-hard and non-smooth optimization problems in many practical applications. Biased-randomized algorithms extend constructive heuristics by introducing a nonuniform randomization pattern into them. Hence, they can be used to explore promising areas of the solution space without the limitations of gradient-based approaches, which assume the existence of smooth objective functions. Moreover, biased-randomized algorithms can be easily parallelized, thus employing short computing times while exploring a large number of promising regions. This paper discusses these concepts in detail, reviews existing work in different application areas, and highlights current trends and open research lines

Scheduling over Scenarios on Two Machines

We consider scheduling problems over scenarios where the goal is to find a single assignment of the jobs to the machines which performs well over all possible scenarios. Each scenario is a subset of jobs that must be executed in that scenario and all scenarios are given explicitly. The two objectives that we consider are minimizing the maximum makespan over all scenarios and minimizing the sum of the makespans of all scenarios. For both versions, we give several approximation algorithms and lower bounds on their approximability. With this research into optimization problems over scenarios, we have opened a new and rich field of interesting problems.Comment: To appear in COCOON 2014. The final publication is available at link.springer.co

Four payment models for the multi-mode resource constrained project scheduling problem with discounted cash flows

In this paper, the multi-mode resource constrained project scheduling problem with discounted cash flows is considered. The objective is the maximization of the net present value of all cash flows. Time value of money is taken into consideration, and cash in- and outflows are associated with activities and/or events. The resources can be of renewable, nonrenewable, and doubly constrained resource types. Four payment models are considered: Lump sum payment at the terminal event, payments at prespecified event nodes, payments at prespecified time points and progress payments. For finding solutions to problems proposed, a genetic algorithm (GA) approach is employed, which uses a special crossover operator that can exploit the multi-component nature of the problem. The models are investigated at the hand of an example problem. Sensitivity analyses are performed over the mark up and the discount rate. A set of 93 problems from literature are solved under the four different payment models and resource type combinations with the GA approach employed resulting in satisfactory computation times. The GA approach is compared with a domain specific heuristic for the lump sum payment case with renewable resources and is shown to outperform it

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems