A Boxology of Design Patterns for Hybrid Learning and Reasoning Systems

We propose a set of compositional design patterns to describe a large variety of systems that combine statistical techniques from machine learning with symbolic techniques from knowledge representation. As in other areas of computer science (knowledge engineering, software engineering, ontology engineering, process mining and others), such design patterns help to systematize the literature, clarify which combinations of techniques serve which purposes, and encourage re-use of software components. We have validated our set of compositional design patterns against a large body of recent literature.Comment: 12 pages,55 reference

A Numerical Slow Manifold Approach to Model Reduction for Optimal Control of Multiple Time Scale ODE

Time scale separation is a natural property of many control systems that can be ex- ploited, theoretically and numerically. We present a numerical scheme to solve optimal control problems with considerable time scale separation that is based on a model reduction approach that does not need the system to be explicitly stated in singularly perturbed form. We present examples that highlight the advantages and disadvantages of the method

A Model-Driven Framework for Enabling Flexible and Robust Mobile Data Collection Applications

In the light of the ubiquitous digital transformation, smart mobile technology has become a salient factor for enabling large-scale data collection scenarios. Structured instruments (e.g., questionnaires) are frequently used to collect data in various application domains, like healthcare, psychology, and social sciences. In current practice, instruments are usually distributed and filled out in a paper-based fashion (e.g., paper-and-pencil questionnaires). The widespread use of smart mobile devices, like smartphones or tablets, offers promising perspectives for the controlled collection of accurate data in high quality. The design, implementation and deployment of mobile data collection applications, however, is a challenging endeavor. First, various mobile operating systems need to be properly supported, taking their short release cycles into account. Second, domain-specific peculiarities need to be flexibly aligned with mobile application development. Third, domain-specific usability guidelines need to be obeyed. Altogether, these challenges turn both programming and maintaining of mobile data collection applications into a costly, time-consuming, and error-prone endeavor. The Ph.D. thesis at hand presents an advanced framework that shall enable domain experts to transform paper-based instruments to mobile data collection applications. The latter, in turn, can then be deployed to and executed on heterogeneous smart mobile devices. In particular, the framework shall empower domain experts (i.e., end-users) to flexibly design and create robust mobile data collection applications on their own; i.e., without need to involve IT experts or mobile application developers. As major benefit, the framework enables the development of sophisticated mobile data collection applications by orders of magnitude faster compared to current approaches, and relieves domain experts from manual tasks like, for example, digitizing and analyzing the collected data

Inviwo -- A Visualization System with Usage Abstraction Levels

The complexity of today's visualization applications demands specific visualization systems tailored for the development of these applications. Frequently, such systems utilize levels of abstraction to improve the application development process, for instance by providing a data flow network editor. Unfortunately, these abstractions result in several issues, which need to be circumvented through an abstraction-centered system design. Often, a high level of abstraction hides low level details, which makes it difficult to directly access the underlying computing platform, which would be important to achieve an optimal performance. Therefore, we propose a layer structure developed for modern and sustainable visualization systems allowing developers to interact with all contained abstraction levels. We refer to this interaction capabilities as usage abstraction levels, since we target application developers with various levels of experience. We formulate the requirements for such a system, derive the desired architecture, and present how the concepts have been exemplary realized within the Inviwo visualization system. Furthermore, we address several specific challenges that arise during the realization of such a layered architecture, such as communication between different computing platforms, performance centered encapsulation, as well as layer-independent development by supporting cross layer documentation and debugging capabilities

Towards green 3D-microfabrication of Bio-MEMS devices using ADEX dry film photoresists

Current trends in miniaturized diagnostics indicate an increasing demand for large quantities of mobile devices for health monitoring and point-of-care diagnostics. This comes along with a need for rapid but preferably also green microfabrication. Dry film photoresists (DFPs) promise low-cost and greener microfabrication and can partly or fully replace conventional silicon-technologies being associated with high-energy demands and the intense use of toxic and climate-active chemicals. Due to their mechanical stability and superior film thickness homogeneity, DFPs outperform conventional spin-on photoresists, such as SU-8, especially when three-dimensional architectures are required for micro-analytical devices (e.g. microfluidics). In this study, we utilize the commercial epoxy-based DFP ADEX to demonstrate various application scenarios ranging from the direct modification of microcantilever beams via the assembly of microfluidic channels to lamination-free patterning of DFPs, which employs the DFP directly as a substrate material. Finally, kinked, bottom-up grown silicon nanowires were integrated in this manner as prospective ion-sensitive field-effect transistors in a bio-probe architecture directly on ADEX substrates. Hence, we have developed the required set of microfabrication protocols for such an assembly comprising metal thin film deposition, direct burn-in of lithography alignment markers, and polymer patterning on top of the DFP