Phase Fluctuation Analysis in Functional Brain Networks of Scaling EEG for Driver Fatigue Detection

The characterization of complex patterns arising from electroencephalogram (EEG) is an important problem with significant applications in identifying different mental states. Based on the operational EEG of drivers, a method is proposed to characterize and distinguish different EEG patterns. The EEG measurements from seven professional taxi drivers were collected under different states. The phase characterization method was used to calculate the instantaneous phase from the EEG measurements. Then, the optimization of drivers’ EEG was realized through performing common spatial pattern analysis. The structures and scaling components of the brain networks from optimized EEG measurements are sensitive to the EEG patterns. The effectiveness of the method is demonstrated, and its applicability is articulated.</p

EEG sleep stages identification based on weighted undirected complex networks

Sleep scoring is important in sleep research because any errors in the scoring of the patient's sleep electroencephalography (EEG) recordings can cause serious problems such as incorrect diagnosis, medication errors, and misinterpretations of patient's EEG recordings. The aim of this research is to develop a new automatic method for EEG sleep stages classification based on a statistical model and weighted brain networks. Methods each EEG segment is partitioned into a number of blocks using a sliding window technique. A set of statistical features are extracted from each block. As a result, a vector of features is obtained to represent each EEG segment. Then, the vector of features is mapped into a weighted undirected network. Different structural and spectral attributes of the networks are extracted and forwarded to a least square support vector machine (LS-SVM) classifier. At the same time the network's attributes are also thoroughly investigated. It is found that the network's characteristics vary with their sleep stages. Each sleep stage is best represented using the key features of their networks. Results In this paper, the proposed method is evaluated using two datasets acquired from different channels of EEG (Pz-Oz and C3-A2) according to the R&K and the AASM without pre-processing the original EEG data. The obtained results by the LS-SVM are compared with those by Naïve, k-nearest and a multi-class-SVM. The proposed method is also compared with other benchmark sleep stages classification methods. The comparison results demonstrate that the proposed method has an advantage in scoring sleep stages based on single channel EEG signals. Conclusions An average accuracy of 96.74% is obtained with the C3-A2 channel according to the AASM standard, and 96% with the Pz-Oz channel based on the R&K standard

Sleep Stage Classification: A Deep Learning Approach

Sleep occupies significant part of human life. The diagnoses of sleep related disorders are of great importance. To record specific physical and electrical activities of the brain and body, a multi-parameter test, called polysomnography (PSG), is normally used. The visual process of sleep stage classification is time consuming, subjective and costly. To improve the accuracy and efficiency of the sleep stage classification, automatic classification algorithms were developed. In this research work, we focused on pre-processing (filtering boundaries and de-noising algorithms) and classification steps of automatic sleep stage classification. The main motivation for this work was to develop a pre-processing and classification framework to clean the input EEG signal without manipulating the original data thus enhancing the learning stage of deep learning classifiers. For pre-processing EEG signals, a lossless adaptive artefact removal method was proposed. Rather than other works that used artificial noise, we used real EEG data contaminated with EOG and EMG for evaluating the proposed method. The proposed adaptive algorithm led to a significant enhancement in the overall classification accuracy. In the classification area, we evaluated the performance of the most common sleep stage classifiers using a comprehensive set of features extracted from PSG signals. Considering the challenges and limitations of conventional methods, we proposed two deep learning-based methods for classification of sleep stages based on Stacked Sparse AutoEncoder (SSAE) and Convolutional Neural Network (CNN). The proposed methods performed more efficiently by eliminating the need for conventional feature selection and feature extraction steps respectively. Moreover, although our systems were trained with lower number of samples compared to the similar studies, they were able to achieve state of art accuracy and higher overall sensitivity

Obstrüktif uyku apne teşhisi için makine öğrenmesi tabanlı yeni bir yöntem geliştirilmesi

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Obstrüktif Uyku Apne (OSA) uykuda solunumun durmasına bağlı olarak ortaya çıkan bir hastalıktır. Hastalığın teşhisi polisomnografi (PSG) cihazı kullanılarak uyku evreleme ve solunum skorlama adımları ile gerçekleştirilir. Sistem yapısı gereği teşhis sırasında hastaya birçok rahatsızlık vermektedir. Verilen rahatsızlıklara çözüm olabilecek, PSG cihazına alternatif sistemlere ihtiyaç duyulmaktadır. Bu tez çalışmasında, PSG cihazına alternatif yeni bir yaklaşım geliştirilmiştir. Bu yaklaşım ile PSG'ye alternatif, hastaya daha az rahatsızlık veren ve PSG kadar güvenilir bir cihazın oluşturulabileceği ispatlanmıştır. Çalışmada, 10 bireyden alınan Fotopletismografi (PPG) sinyali kullanılmıştır. Teşhis için PPG sinyali ve bu sinyalden türetilen Kalp Hızı Değişkeni (HRV) kullanılarak yapay zeka tabanlı teşhis algoritması tasarlanmıştır. Çalışma için PPG'den 46, HRV'den 40 adet olmak üzere toplam 86 özellik çıkarılmıştır. Çıkarılan özelliklerin, Mann-Whitney U Testi yöntemiyle, istatistiksel olarak, uyku uyanıklık ve anormal solunumsal olaylar (apne var - yok) için ayırt edici olup olmadığı tespit edilmeye çalışılmıştır. Ayrıca, özellikler, F-score özellik seçme yöntemleriyle 2 defa azaltılmış ve sınıflandırılmıştır. İstatistiksel sonuçlara göre, uyku evreleme işlemi için, 86 özellikten 75'inin uyku uyanıklık için anlamlı olduğu (p<0,05), solunum skorlamada ise 58 özelliğin anlamlı olduğu (p<0,05) tespit edilmiştir. Sınıflandırma sonuçlarına göre uyku evreleme 11 özellik ile, %84,93 duyarlılık, %97,40 özgüllük ve %91,09 sınıflandırma doğruluk oranı ile topluluk sınıflandırıcısı yardımıyla başarı ile sınıflandırılmıştır. Solunum skorlama işlemi, 86 özellik ile, %87,78 duyarlılık, %95,46 özgüllük ve %92,54 doğruluk oranı ile başarıyla gerçekleştirilmiştir. Bu çalışmada elde edilen sonuçlara göre, PPG sinyali ve bu sinyalden türetilen HRV özelliklerinin uyku evreleme ve solunum skorlama işleminde kullanılabileceği ve anlamlı sonuçlar vereceği kanısına varılmıştır. PPG sinyalinin kolay elde edilebilmesi ve HRV'nin PPG sinyalinden türetilmesi tek sinyal ile uyku evreleme ve solunum skorlama işleminin yapılabilmesinin önünü açmaktadır. Gerçek zamanlı çalışabilecek sistemlerde sinyalin kolay ölçülebilir ve kolay işlenebilir olması sistemlerin pratikliğini arttıracaktır.Obstructive Sleep Apnea (OSA) is a disease caused by breathlessness in sleep. Diagnosis of the disease is performed by polysomnography (PSG) device with sleep staging and respiratory scoring steps. The system structure causes many discomfort to the patient during diagnosis. Alternative systems are needed for the PSG device, which can be a solution to the inconveniences. In this thesis study, a new approach was developed to PSG device. This approach has been proven that an alternative to PSG is to create a device that is less disturbing to the patient and as reliable as PSG. In the study, a Photoplethysmography (PPG) signal from 10 individuals was used. For diagnosis, an artificial intelligence-based diagnostic algorithm is designed using PPG signal and Heart Rate Variable (HRV) derived from PPG. For the study, 86 features were extracted, 46 of PPG and 40 of HRV. Statistically, the Mann-Whitney U test was used to determine whether the extracted features were discriminatory for sleep – wakefulness and abnormal respiratory events (apnea present - absent). In addition, features are reduced by F-score property selection methods 2 times and classified. According to the statistical results, 75 of the 86 features were significant for sleep awake (p<0,05) and 58 for respiratory scoring (p<0,05). According to the classification results, the sleep classification was successfully classified with the help of ensemble classifier with 11 features, 84,93% sensitivity, 97,40% specificity and 91,09% classification accuracy. Respiratory scoring was successfully performed with 86 features with 87,78% sensitivity, 95.46% specificity and 92.54% classification accuracy. According to the results obtained in this study, it was concluded that features of the PPG signal and the HRV derived from PPG can be used in the sleep staging and respiratory scoring process and have meaningful results. The easy acquisition of the PPG signal and the derivation of the HRV from the PPG signal opens up the possibility of performing sleep staging and respiratory scoring with a single signal. In systems that can operate in real time, easy measurement and easy handling of the signal will increase the practicality of the systems

Feature Extraction and Selection in Automatic Sleep Stage Classification

Sleep stage classification is vital for diagnosing many sleep related disorders and Polysomnography (PSG) is an important tool in this regard. The visual process of sleep stage classification is time consuming, subjective and costly. To improve the accuracy and efficiency of the sleep stage classification, researchers have been trying to develop automatic classification algorithms. The automatic sleep stage classification mainly consists of three steps: pre-processing, feature extraction and classification. In this research work, we focused on feature extraction and selection steps. The main goal of this thesis was identifying a robust and reliable feature set that can lead to efficient classification of sleep stages. For achieving this goal, three types of contributions were introduced in feature selection, feature extraction and feature vector quality enhancement. Several feature ranking and rank aggregation methods were evaluated and compared for finding the best feature set. Evaluation results indicated that the decision on the precise feature selection method depends on the system design requirements such as low computational complexity, high stability or high classification accuracy. In addition to conventional feature ranking methods, in this thesis, novel methods such as Stacked Sparse AutoEncoder (SSAE) was used for dimensionality reduction. In feature extration area, new and effective features such as distancebased features were utilized for the first time in sleep stage classification. The results showed that these features contribute positively to the classification performance. For signal quality enhancement, a loss-less EEG artefact removal algorithm was proposed. The proposed adaptive algorithm led to a significant enhancement in the overall classification accuracy

Development of cognitive workload models to detect driving impairment

Tesi redactada en castellàDriving a vehicle is a complex activity exposed to continuous changes such as speed limits and vehicular traffic. Drivers require a high degree of concentration when performing this activity, increasing the amount of mental demand known as cognitive workload, causing vehicular accidents to the minimum negligence. In fact, human error is the leading contributing factor in over 90% of road accidents. In recent years, the subjects' cognitive workload levels while driving a vehicle have been predicted using subjective and vehicle performance tools. Other research has emphasized the use and analysis of physiological information, where electroencephalographic (EEG) signals are the most used to identify cognitive states due to their high precision. Although significant progress has been made in this area, these investigations have been based on traditional techniques or data analysis from a specific source due to the information's complexity. A new trend has been opened in the study of the internal behavior of subjects by implementing machine learning techniques to analyze information from various sources. However, there are still several challenges to face in this new line of research. This doctoral thesis presents a new model to predict the states of low and high cognitive workload of subjects when facing scenarios of driving a vehicle called GALoRSI-SVMRBF (Genetic Algorithms and Logistic Regression for the Structuring of Information-Support Vector Machine with Radial Basis Function Kernel). GALoRSI-SVMRBF is developed using machine learning algorithms based on information from EEG signals. Also, the information collected from NASA-TLX, instant online self-assessment and the error rate measure are implemented in the model. First, GALoRSI-SVMRBF proposes a new method for pattern recognition based on feature selection that combines statistical tests, genetic algorithms, and logistic regression. This method consists mainly of selecting an EEG dataset and exploring the information to identify the key features that recognize cognitive states. The selected data are defined as an index for pattern recognition and used to structure a new dataset capable of optimizing the model's learning and classification process. Second, the methodology and development of a classifier for the prediction model are presented, implementing machine learning algorithms. The classifier is developed mainly in two phases, defined as training and testing. Once the prediction model has been developed, this thesis presents the validation phase of GALoRSI-SVMRBF. The validation consists of evaluating the model's adaptability to new datasets, maintaining a high prediction rate. Finally, an analysis of the performance of GALoRSI-SVMRBF is presented. The objective is to know the model's scope and limitations, evaluating various performance metrics to find the optimal configuration for GALoRSI-SVMRBF. We found that GALoRSI-SVMRBF successfully predicts low and high cognitive workload of subjects while driving a vehicle. In general, it is observed that the model uses the information extracted from multiple EEG signals, reducing the original dataset by more than 50%, maximizing its predictive capacity, achieving a precision rate of >90% in the classification of the information. During this thesis, the experiments showed that obtaining a high percentage of prediction depends on several factors, from applying a useful collection technique data until the last step of the prediction model.La conducción de un vehículo es una actividad compleja que está expuesta a demandas que cambian continuamente por diferentes factores, tales como, el límite de velocidad, obstáculos en la vía, tráfico vehicular, entre otros. Al desempeñar esta actividad, los conductores requieren un alto grado de concentración incrementando la cantidad de demanda mental conocida como carga. En los últimos años, se han propuesto mecanismos para monitorear y/o predecir los niveles de carga cognitiva de los sujetos al conducir un vehículo, centrándose en el uso de herramientas subjetivas y de rendimiento vehicular. Otras investigaciones, han enfatizado en el uso y análisis de la información fisiológica, siendo las señales electroencefalográficas (EEG) las más utilizadas para identificar los estados cognitivos por su alta precisión. A pesar del gran avance realizado, estas investigaciones se han basado en técnicas tradicionales o en el análisis de la información proveniente de fuentes específicas para identificar el estado interno del sujeto, obteniendo modelos sobreentrenados o robustos, incrementando el tiempo de análisis afectando el desempeño del modelo. En esta tesis doctoral se presenta un nuevo modelo para predecir los estados de baja y alta carga cognitiva de los sujetos al enfrentarse a escenarios de la conducción de un vehículo denominado GALoRSI-SVMRBF (Genetic Algorithms and Logistic Regression for the Structuring of Information-Support Vector Machine with Radial Basis Function Kernel). GALoRSI-SVMRBF fue desarrollado utilizando los algoritmos de aprendizaje automático y técnicas estadísticas basado en la información proveniente de las señales EEG. Primero, GALoRSI-SVMRBF crea una base de datos extrayendo las características que serán utilizadas en el modelo a través de técnicas estadísticas. Posteriormente, propone un nuevo método para el reconocimiento de patrones basado en la selección de características que combina pruebas estadísticas, algoritmos genéticos y regresión logística. Este método consiste principalmente en seleccionar un conjunto de datos EEG y explorar la combinación de la información para identificar las características claves que contribuyan al reconocimiento de dos estados cognitivos. Después, la información seleccionada es definida como un índice para el reconocimiento de patrones y utilizada para estructurar un nuevo conjunto de datos que soporta información de uno o múltiples canales para optimizar el proceso de aprendizaje y clasificación del modelo. Por último, es desarrollado el clasificador del modelo de predicciones el cual consiste en dos etapas definidas como entrenamiento y prueba. Nosotros encontramos que GALoRSI-SVMRBF predice de manera exitosa la carga cognitiva baja y alta de los sujetos durante la conducción de un vehículo. En general, se observó que el modelo utiliza la información extraída de una o múltiples señales EEG y logrando una tasa de precisión >90% en la clasificación de la informaciónPostprint (published version