37,126 research outputs found
Longitudinal structural and perfusion MRI enhanced by machine learning outperforms standalone modalities and radiological expertise in high-grade glioma surveillance
PURPOSE: Surveillance of patients with high-grade glioma (HGG) and identification of disease progression remain a major challenge in neurooncology. This study aimed to develop a support vector machine (SVM) classifier, employing combined longitudinal structural and perfusion MRI studies, to classify between stable disease, pseudoprogression and progressive disease (3-class problem). METHODS: Study participants were separated into two groups: group I (total cohort: 64 patients) with a single DSC time point and group II (19 patients) with longitudinal DSC time points (2-3). We retrospectively analysed 269 structural MRI and 92 dynamic susceptibility contrast perfusion (DSC) MRI scans. The SVM classifier was trained using all available MRI studies for each group. Classification accuracy was assessed for different feature dataset and time point combinations and compared to radiologists’ classifications. RESULTS: SVM classification based on combined perfusion and structural features outperformed radiologists’ classification across all groups. For the identification of progressive disease, use of combined features and longitudinal DSC time points improved classification performance (lowest error rate 1.6%). Optimal performance was observed in group II (multiple time points) with SVM sensitivity/specificity/accuracy of 100/91.67/94.7% (first time point analysis) and 85.71/100/94.7% (longitudinal analysis), compared to 60/78/68% and 70/90/84.2% for the respective radiologist classifications. In group I (single time point), the SVM classifier also outperformed radiologists’ classifications with sensitivity/specificity/accuracy of 86.49/75.00/81.53% (SVM) compared to 75.7/68.9/73.84% (radiologists). CONCLUSION: Our results indicate that utilisation of a machine learning (SVM) classifier based on analysis of longitudinal perfusion time points and combined structural and perfusion features significantly enhances classification outcome (p value= 0.0001)
ICLabel: An automated electroencephalographic independent component classifier, dataset, and website
The electroencephalogram (EEG) provides a non-invasive, minimally
restrictive, and relatively low cost measure of mesoscale brain dynamics with
high temporal resolution. Although signals recorded in parallel by multiple,
near-adjacent EEG scalp electrode channels are highly-correlated and combine
signals from many different sources, biological and non-biological, independent
component analysis (ICA) has been shown to isolate the various source generator
processes underlying those recordings. Independent components (IC) found by ICA
decomposition can be manually inspected, selected, and interpreted, but doing
so requires both time and practice as ICs have no particular order or intrinsic
interpretations and therefore require further study of their properties.
Alternatively, sufficiently-accurate automated IC classifiers can be used to
classify ICs into broad source categories, speeding the analysis of EEG studies
with many subjects and enabling the use of ICA decomposition in near-real-time
applications. While many such classifiers have been proposed recently, this
work presents the ICLabel project comprised of (1) an IC dataset containing
spatiotemporal measures for over 200,000 ICs from more than 6,000 EEG
recordings, (2) a website for collecting crowdsourced IC labels and educating
EEG researchers and practitioners about IC interpretation, and (3) the
automated ICLabel classifier. The classifier improves upon existing methods in
two ways: by improving the accuracy of the computed label estimates and by
enhancing its computational efficiency. The ICLabel classifier outperforms or
performs comparably to the previous best publicly available method for all
measured IC categories while computing those labels ten times faster than that
classifier as shown in a rigorous comparison against all other publicly
available EEG IC classifiers.Comment: Intended for NeuroImage. Updated from version one with minor
editorial and figure change
Classifier Subset Selection to construct multi-classifiers by means of estimation of distribution algorithms
This paper proposes a novel approach to select the individual classifiers to take part in a Multiple-Classifier System. Individual classifier selection is a key step in the development of multi-classifiers. Several works have shown the benefits of fusing complementary classifiers. Nevertheless, the selection of the base classifiers to be used is still an open question, and different approaches have been proposed in the literature. This work is based on the selection of the appropriate single classifiers by means of an evolutionary algorithm. Different base classifiers, which have been chosen from different classifier families, are used as candidates in order to obtain variability in the classifications given. Experimental results carried out with 20 databases from the UCI Repository show how adequate the proposed approach is; Stacked Generalization multi-classifier has been selected to perform the experimental comparisons.The work described in this paper was partially conducted within the Basque Government Research Team grant and the University of the Basque Country UPV/EHU and under grant UFI11/45 (BAILab)
Identification of an Efficient Gene Expression Panel for Glioblastoma Classification.
We present here a novel genetic algorithm-based random forest (GARF) modeling technique that enables a reduction in the complexity of large gene disease signatures to highly accurate, greatly simplified gene panels. When applied to 803 glioblastoma multiforme samples, this method allowed the 840-gene Verhaak et al. gene panel (the standard in the field) to be reduced to a 48-gene classifier, while retaining 90.91% classification accuracy, and outperforming the best available alternative methods. Additionally, using this approach we produced a 32-gene panel which allows for better consistency between RNA-seq and microarray-based classifications, improving cross-platform classification retention from 69.67% to 86.07%. A webpage producing these classifications is available at http://simplegbm.semel.ucla.edu
Robust Classification for Imprecise Environments
In real-world environments it usually is difficult to specify target
operating conditions precisely, for example, target misclassification costs.
This uncertainty makes building robust classification systems problematic. We
show that it is possible to build a hybrid classifier that will perform at
least as well as the best available classifier for any target conditions. In
some cases, the performance of the hybrid actually can surpass that of the best
known classifier. This robust performance extends across a wide variety of
comparison frameworks, including the optimization of metrics such as accuracy,
expected cost, lift, precision, recall, and workforce utilization. The hybrid
also is efficient to build, to store, and to update. The hybrid is based on a
method for the comparison of classifier performance that is robust to imprecise
class distributions and misclassification costs. The ROC convex hull (ROCCH)
method combines techniques from ROC analysis, decision analysis and
computational geometry, and adapts them to the particulars of analyzing learned
classifiers. The method is efficient and incremental, minimizes the management
of classifier performance data, and allows for clear visual comparisons and
sensitivity analyses. Finally, we point to empirical evidence that a robust
hybrid classifier indeed is needed for many real-world problems.Comment: 24 pages, 12 figures. To be published in Machine Learning Journal.
For related papers, see http://www.hpl.hp.com/personal/Tom_Fawcett/ROCCH
A Bayesian approach to star-galaxy classification
Star-galaxy classification is one of the most fundamental data-processing
tasks in survey astronomy, and a critical starting point for the scientific
exploitation of survey data. For bright sources this classification can be done
with almost complete reliability, but for the numerous sources close to a
survey's detection limit each image encodes only limited morphological
information. In this regime, from which many of the new scientific discoveries
are likely to come, it is vital to utilise all the available information about
a source, both from multiple measurements and also prior knowledge about the
star and galaxy populations. It is also more useful and realistic to provide
classification probabilities than decisive classifications. All these
desiderata can be met by adopting a Bayesian approach to star-galaxy
classification, and we develop a very general formalism for doing so. An
immediate implication of applying Bayes's theorem to this problem is that it is
formally impossible to combine morphological measurements in different bands
without using colour information as well; however we develop several
approximations that disregard colour information as much as possible. The
resultant scheme is applied to data from the UKIRT Infrared Deep Sky Survey
(UKIDSS), and tested by comparing the results to deep Sloan Digital Sky Survey
(SDSS) Stripe 82 measurements of the same sources. The Bayesian classification
probabilities obtained from the UKIDSS data agree well with the deep SDSS
classifications both overall (a mismatch rate of 0.022, compared to 0.044 for
the UKIDSS pipeline classifier) and close to the UKIDSS detection limit (a
mismatch rate of 0.068 compared to 0.075 for the UKIDSS pipeline classifier).
The Bayesian formalism developed here can be applied to improve the reliability
of any star-galaxy classification schemes based on the measured values of
morphology statistics alone.Comment: Accepted 22 November 2010, 19 pages, 17 figure
Six Noise Type Military Sound Classifier
Blast noise from military installations often has a negative impact on the quality of life of residents living in nearby communities. This negatively impacts the military's testing \& training capabilities due to restrictions, curfews, or range closures enacted to address noise complaints. In order to more directly manage noise around military installations, accurate noise monitoring has become a necessity. Although most noise monitors are simple sound level meters, more recent ones are capable of discerning blasts from ambient noise with some success. Investigators at the University of Pittsburgh previously developed a more advanced noise classifier that can discern between wind, aircraft, and blast noise, while simultaneously lowering the measurement threshold. Recent work will be presented from the development of a more advanced classifier that identifies additional classes of noise such as machine gun fire, vehicles, and thunder. Additional signal metrics were explored given the increased complexity of the classifier. By broadening the types of noise the system can accurately classify and increasing the number of metrics, a new system was developed with increased blast noise accuracy, decreased number of missed events, and significantly fewer false positives
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