Review : Deep learning in electron microscopy

Deep learning is transforming most areas of science and technology, including electron microscopy. This review paper offers a practical perspective aimed at developers with limited familiarity. For context, we review popular applications of deep learning in electron microscopy. Following, we discuss hardware and software needed to get started with deep learning and interface with electron microscopes. We then review neural network components, popular architectures, and their optimization. Finally, we discuss future directions of deep learning in electron microscopy

Robust Distributed Multi-Source Detection and Labeling in Wireless Acoustic Sensor Networks

The growing demand in complex signal processing methods associated with low-energy large scale wireless acoustic sensor networks (WASNs) urges the shift to a new information and communication technologies (ICT) paradigm. The emerging research perception aspires for an appealing wireless network communication where multiple heterogeneous devices with different interests can cooperate in various signal processing tasks (MDMT). Contributions in this doctoral thesis focus on distributed multi-source detection and labeling applied to audio enhancement scenarios pursuing an MDMT fashioned node-specific source-of-interest signal enhancement in WASNs. In fact, an accurate detection and labeling is a pre-requisite to pursue the MDMT paradigm where nodes in the WASN communicate effectively their sources-of-interest and, therefore, multiple signal processing tasks can be enhanced via cooperation. First, a novel framework based on a dominant source model in distributed WASNs for resolving the activity detection of multiple speech sources in a reverberant and noisy environment is introduced. A preliminary rank-one multiplicative non-negative independent component analysis (M-NICA) for unique dominant energy source extraction given associated node clusters is presented. Partitional algorithms that minimize the within-cluster mean absolute deviation (MAD) and weighted MAD objectives are proposed to determine the cluster membership of the unmixed energies, and thus establish a source specific voice activity recognition. In a second study, improving the energy signal separation to alleviate the multiple source activity discrimination task is targeted. Sparsity inducing penalties are enforced on iterative rank-one singular value decomposition layers to extract sparse right rotations. Then, sparse non-negative blind energy separation is realized using multiplicative updates. Hence, the multiple source detection problem is converted into a sparse non-negative source energy decorrelation. Sparsity tunes the supposedly non-active energy signatures to exactly zero-valued energies so that it is easier to identify active energies and an activity detector can be constructed in a straightforward manner. In a centralized scenario, the activity decision is controlled by a fusion center that delivers the binary source activity detection for every participating energy source. This strategy gives precise detection results for small source numbers. With a growing number of interfering sources, the distributed detection approach is more promising. Conjointly, a robust distributed energy separation algorithm for multiple competing sources is proposed. A robust and regularized $t_{\nu}M$-estimation of the covariance matrix of the mixed energies is employed. This approach yields a simple activity decision using only the robustly unmixed energy signatures of the sources in the WASN. The performance of the robust activity detector is validated with a distributed adaptive node-specific signal estimation method for speech enhancement. The latter enhances the quality and intelligibility of the signal while exploiting the accurately estimated multi-source voice decision patterns. In contrast to the original M-NICA for source separation, the extracted binary activity patterns with the robust energy separation significantly improve the node-specific signal estimation. Due to the increased computational complexity caused by the additional step of energy signal separation, a new approach to solving the detection question of multi-device multi-source networks is presented. Stability selection for iterative extraction of robust right singular vectors is considered. The sub-sampling selection technique provides transparency in properly choosing the regularization variable in the Lasso optimization problem. In this way, the strongest sparse right singular vectors using a robust $\ell_1$-norm and stability selection are the set of basis vectors that describe the input data efficiently. Active/non-active source classification is achieved based on a robust Mahalanobis classifier. For this, a robust $M$-estimator of the covariance matrix in the Mahalanobis distance is utilized. Extensive evaluation in centralized and distributed settings is performed to assess the effectiveness of the proposed approach. Thus, overcoming the computationally demanding source separation scheme is possible via exploiting robust stability selection for sparse multi-energy feature extraction. With respect to the labeling problem of various sources in a WASN, a robust approach is introduced that exploits the direction-of-arrival of the impinging source signals. A short-time Fourier transform-based subspace method estimates the angles of locally stationary wide band signals using a uniform linear array. The median of angles estimated at every frequency bin is utilized to obtain the overall angle for each participating source. The features, in this case, exploit the similarity across devices in the particular frequency bins that produce reliable direction-of-arrival estimates for each source. Reliability is defined with respect to the median across frequencies. All source-specific frequency bands that contribute to correct estimated angles are selected. A feature vector is formed for every source at each device by storing the frequency bin indices that lie within the upper and lower interval of the median absolute deviation scale of the estimated angle. Labeling is accomplished by a distributed clustering of the extracted angle-based feature vectors using consensus averaging

Proceedings of the 35th WIC Symposium on Information Theory in the Benelux and the 4th joint WIC/IEEE Symposium on Information Theory and Signal Processing in the Benelux, Eindhoven, the Netherlands May 12-13, 2014

Compressive sensing (CS) as an approach for data acquisition has recently received much attention. In CS, the signal recovery problem from the observed data requires the solution of a sparse vector from an underdetermined system of equations. The underlying sparse signal recovery problem is quite general with many applications and is the focus of this talk. The main emphasis will be on Bayesian approaches for sparse signal recovery. We will examine sparse priors such as the super-Gaussian and student-t priors and appropriate MAP estimation methods. In particular, re-weighted l2 and re-weighted l1 methods developed to solve the optimization problem will be discussed. The talk will also examine a hierarchical Bayesian framework and then study in detail an empirical Bayesian method, the Sparse Bayesian Learning (SBL) method. If time permits, we will also discuss Bayesian methods for sparse recovery problems with structure; Intra-vector correlation in the context of the block sparse model and inter-vector correlation in the context of the multiple measurement vector problem

Proceedings of the 35th WIC Symposium on Information Theory in the Benelux and the 4th joint WIC/IEEE Symposium on Information Theory and Signal Processing in the Benelux, Eindhoven, the Netherlands May 12-13, 2014

Compressive sensing (CS) as an approach for data acquisition has recently received much attention. In CS, the signal recovery problem from the observed data requires the solution of a sparse vector from an underdetermined system of equations. The underlying sparse signal recovery problem is quite general with many applications and is the focus of this talk. The main emphasis will be on Bayesian approaches for sparse signal recovery. We will examine sparse priors such as the super-Gaussian and student-t priors and appropriate MAP estimation methods. In particular, re-weighted l2 and re-weighted l1 methods developed to solve the optimization problem will be discussed. The talk will also examine a hierarchical Bayesian framework and then study in detail an empirical Bayesian method, the Sparse Bayesian Learning (SBL) method. If time permits, we will also discuss Bayesian methods for sparse recovery problems with structure; Intra-vector correlation in the context of the block sparse model and inter-vector correlation in the context of the multiple measurement vector problem

Principled methods for mixtures processing

This document is my thesis for getting the habilitation à diriger des recherches, which is the french diploma that is required to fully supervise Ph.D. students. It summarizes the research I did in the last 15 years and also provides the short­term research directions and applications I want to investigate. Regarding my past research, I first describe the work I did on probabilistic audio modeling, including the separation of Gaussian and α­stable stochastic processes. Then, I mention my work on deep learning applied to audio, which rapidly turned into a large effort for community service. Finally, I present my contributions in machine learning, with some works on hardware compressed sensing and probabilistic generative models.My research programme involves a theoretical part that revolves around probabilistic machine learning, and an applied part that concerns the processing of time series arising in both audio and life sciences

Fundamentals

Volume 1 establishes the foundations of this new field. It goes through all the steps from data collection, their summary and clustering, to different aspects of resource-aware learning, i.e., hardware, memory, energy, and communication awareness. Machine learning methods are inspected with respect to resource requirements and how to enhance scalability on diverse computing architectures ranging from embedded systems to large computing clusters