Spatio of lungs Tuberculosis (Tb Lungs) in East Java Using Geographically Weighted Poisson Regression (GWPR)

Pulmonary tuberculosis patients lose nearly 40% of their productive time. This results in reduced productivity if he is the head of the family or productive. In addition, pulmonary tuberculosis patients become highly dangerous transmitters if they do not pay attention to handling the correct cough and being in a location with a high sexual percentage. Likewise, people who are hurt, will have great information, contracting, if any, and very experienced. This study aims to map the grouping of tuberculosis patients and who are at risk of contracting by time rather than looking at the factors that influence it by using poisson regression that address the presence of GWPR over dispersion. The results obtained there are 5 grouping of areas, with the most significant factors of the district plus the ratio of Trenggalek basic health facilities (Z2) and the percentage of school (Z4) and poor population (X1), BTA + (X2), HIV/AIDS incidence rate (X3) incidence of diabetes mellitus (X4), population density (X5) and ratio of health personnel (X6)

Similarities of Antimalarial Resistance Genes in Plasmodium Falciparum Based on Ontology

The finding of P. falciparum chloroquine resistance (pfcrt) and P. falciparum multidrug resistance 1(pfmdr1) gene in P. falciparum has become an obstacle in treating malaria. The polymorphism between the two genes may result in molecular functions, in cellular components, or in biological processes. The objective of this research is to find similarities between the two genes in 3 components; cellular components, molecular functions and biological processes, based on Gene Ontology. the similarity will be counted semantically by path length approach with Wang method. The range of similarity values is 0-1. After the similarity value examined; in Molecular Function the similarity is 1 due to the same drug transmembrane transporter activity, in Cellular Component is 0,714, the similarity only at the same vacuole food cells, and in Biological Processes is 1 due to the same proces in responding to drug. Therefore, this research proves both genes have similarities based on gene ontology

Sensitivity and Specificity of Rapid Diagnostic Test with Microscopic Gold Standard to Identify Plasmodium Species

Malaria is a main health problem in islands area which is under developed and isolated. Nation-wide, in 2014 Maluku province was recorded to have Annual Malaria Incident (AMI) value of 30.4%, positive incidents of 13.30%, ABER 3.76%, SPR 21.50%, and Annual Paracite Incident (API) 8.10%, while South Buru Regency has a value of Annual Malaria Incident (AMI) of 14.49%, 494 positive incidents, ABER 1.12%, SPR 60.91%, and Annual Paracite Incident (API) 6.86%. The purpose of this study was to identify Plasmodium species in malaria incidents in NamroleSubdistrict, South Buru Regency, Maluku Province. Observational research with a sample of 64 respondents for symptomatic and asymptomatic malaria. The instrument for the research was Rapid Diagnostic Test (RDT) and microscopic Gold Standard. Result: Malaria examination by using RDT suggested 3 kinds of parasites, i.e., P. falciparum, P. Vivax, and a mix between P. falciparum and P. vivax. Most parasites found were P. falciparum 56.3%. The accuracy of RDT examination was proven with microscopic test and the result suggested that the RDT sensitivity was 100% and the specifivity was 63.3%. Positive predictive value was 92.9% and negative predictive value was 100%, both were for positive likelihood ration of 2.75%. While for negative likelihood ration of 0%, the value of degree of conformity (Kappa) between RDT and microscopic is 0%. RDT has one benefit that it can be use to conduct malaria diagnosis rapidly, particularly in isolated areas. The benefit of Rapid Diagnostic Test (RDT) was that it could be used in remote and isolated areas to conduct diagnosis. RDT is highly effective and efficient

Sensitivity and Specificity of Rapid Diagnostic Test with Microscopic Gold Standard to Identify Plasmodium Species

Abstract Malaria is a main health problem in islands area which is under developed and isolated. Nation-wide, in 2014 Maluku province was recorded to have Annual Malaria Incident (AMI) value of 30.4%, positive incidents of 13.30%, ABER 3.76%, SPR 21.50%, and Annual Paracite Incident (API) 8.10%, while South Buru Regency has a value of Annual Malaria Incident (AMI) of 14.49%, 494 positive incidents, ABER 1.12%, SPR 60.91%, and Annual Paracite Incident (API) 6.86%. The purpose of this study was to identify Plasmodium species in malaria incidents in NamroleSubdistrict, South Buru Regency, Maluku Province. Observational research with a sample of 64 respondents for symptomatic and asymptomatic malaria. The instrument for the research was Rapid Diagnostic Test (RDT) and microscopic Gold Standard. Result: Malaria examination by using RDT suggested 3 kinds of parasites, i.e., P. falciparum, P. Vivax, and a mix between P. falciparum and P. vivax. Most parasites found were P. falciparum 56.3%. The accuracy of RDT examination was proven with microscopic test and the result suggested that the RDT sensitivity was 100% and the specifivity was 63.3%. Positive predictive value was 92.9% and negative predictive value was 100%, both were for positive likelihood ration of 2.75%. While for negative likelihood ration of 0%, the value of degree of conformity (Kappa) between RDT and microscopic is 0%. RDT has one benefit that it can be use to conduct malaria diagnosis rapidly, particularly in isolated areas. The benefit of Rapid Diagnostic Test (RDT) was that it could be used in remote and isolated areas to conduct diagnosis. RDT is highly effective and efficient