Marvin: Semantic annotation using multiple knowledge sources

People are producing more written material then anytime in the history. The increase is so high that professionals from the various fields are no more able to cope with this amount of publications. Text mining tools can offer tools to help them and one of the tools that can aid information retrieval and information extraction is semantic text annotation. In this report we present Marvin, a text annotator written in Java, which can be used as a command line tool and as a Java library. Marvin is able to annotate text using multiple sources, including WordNet, MetaMap, DBPedia and thesauri represented as SKOS.Comment: 9 pages, 4 figures, keywords: Semantic annotation, text normalization, semantic web, linked data, information management, text mining, information extraction, data curatio

Large-scale event extraction from literature with multi-level gene normalization

Text mining for the life sciences aims to aid database curation, knowledge summarization and information retrieval through the automated processing of biomedical texts. To provide comprehensive coverage and enable full integration with existing biomolecular database records, it is crucial that text mining tools scale up to millions of articles and that their analyses can be unambiguously linked to information recorded in resources such as UniProt, KEGG, BioGRID and NCBI databases. In this study, we investigate how fully automated text mining of complex biomolecular events can be augmented with a normalization strategy that identifies biological concepts in text, mapping them to identifiers at varying levels of granularity, ranging from canonicalized symbols to unique gene and proteins and broad gene families. To this end, we have combined two state-of-the-art text mining components, previously evaluated on two community-wide challenges, and have extended and improved upon these methods by exploiting their complementary nature. Using these systems, we perform normalization and event extraction to create a large-scale resource that is publicly available, unique in semantic scope, and covers all 21.9 million PubMed abstracts and 460 thousand PubMed Central open access full-text articles. This dataset contains 40 million biomolecular events involving 76 million gene/protein mentions, linked to 122 thousand distinct genes from 5032 species across the full taxonomic tree. Detailed evaluations and analyses reveal promising results for application of this data in database and pathway curation efforts. The main software components used in this study are released under an open-source license. Further, the resulting dataset is freely accessible through a novel API, providing programmatic and customized access (http://www.evexdb.org/api/v001/). Finally, to allow for large-scale bioinformatic analyses, the entire resource is available for bulk download from http://evexdb.org/download/, under the Creative Commons -Attribution - Share Alike (CC BY-SA) license

Ontology-Driven Semantic Enrichment Framework for Open Data Value Creation

The reviewed semantic enrichment frameworks lack mechanisms to assess the degree of semantic value added to flat-text resources in terms of knowledge and semantic capabilities. This complicates the tasks of driving the semantic value creation process toward the specific enrichment output and evaluating the output. In addressing this gap, we propose the semantic value creation solution, which converts flat-text resources to knowledge resources. Namely, we propose the ontology-driven semantic enrichment (ODSE) framework, with a mechanism for semantic valuation. The framework’s development involved adopting the design science research methodology for information systems. The developed framework leverages linked data principles for knowledge creation. This framework was demonstrated to determine the semantic capabilities enabled by the syntax additions, as well as the knowledge enabled by the semantic additions to flat-text resources, along with its potential impact on knowledge creation, mining, and resource-usability effectiveness. The ODSE framework is reusable in semantic value creation implementations that transform a flat text to semantic formats

Automating Metadata Extraction: Genre Classification

A problem that frequently arises in the management and integration of scientific data is the lack of context and semantics that would link data encoded in disparate ways. To bridge the discrepancy, it often helps to mine scientific texts to aid the understanding of the database. Mining relevant text can be significantly aided by the availability of descriptive and semantic metadata. The Digital Curation Centre (DCC) has undertaken research to automate the extraction of metadata from documents in PDF([22]). Documents may include scientific journal papers, lab notes or even emails. We suggest genre classification as a first step toward automating metadata extraction. The classification method will be built on looking at the documents from five directions; as an object of specific visual format, a layout of strings with characteristic grammar, an object with stylo-metric signatures, an object with meaning and purpose, and an object linked to previously classified objects and external sources. Some results of experiments in relation to the first two directions are described here; they are meant to be indicative of the promise underlying this multi-faceted approach.

OrganismTagger: detection, normalization and grounding of organism entities in biomedical documents

Motivation: Semantic tagging of organism mentions in full-text articles is an important part of literature mining and semantic enrichment solutions. Tagged organism mentions also play a pivotal role in disambiguating other entities in a text, such as proteins. A high-precision organism tagging system must be able to detect the numerous forms of organism mentions, including common names as well as the traditional taxonomic groups: genus, species and strains. In addition, such a system must resolve abbreviations and acronyms, assign the scientific name and if possible link the detected mention to the NCBI Taxonomy database for further semantic queries and literature navigation. Results: We present the OrganismTagger, a hybrid rule-based/machine learning system to extract organism mentions from the literature. It includes tools for automatically generating lexical and ontological resources from a copy of the NCBI Taxonomy database, thereby facilitating system updates by end users. Its novel ontology-based resources can also be reused in other semantic mining and linked data tasks. Each detected organism mention is normalized to a canonical name through the resolution of acronyms and abbreviations and subsequently grounded with an NCBI Taxonomy database ID. In particular, our system combines a novel machine-learning approach with rule-based and lexical methods for detecting strain mentions in documents. On our manually annotated OT corpus, the OrganismTagger achieves a precision of 95%, a recall of 94% and a grounding accuracy of 97.5%. On the manually annotated corpus of Linnaeus-100, the results show a precision of 99%, recall of 97% and grounding accuracy of 97.4%. Availability: The OrganismTagger, including supporting tools, resources, training data and manual annotations, as well as end user and developer documentation, is freely available under an open-source license at http://www.semanticsoftware.info/organism-tagger. Contact: [email protected]

Extracting and re-using research data from chemistry e-theses: the SPECTRa-T project

Scientific e-theses are data-rich resources, but much of the information they contain is not readily accessible. For chemistry, the SPECTRa-T project has addressed this problem by developing data-mining techniques to extract experimental data, creating RDF (Resource Description Framework) triples for exposure to sophisticated Semantic Web searches. We used OSCAR3, an Open Source chemistry text-mining tool, to parse and extract data from theses in PDF, and from theses in Office Open XML document format. Theses in PDF suffered data corruption and a loss of formatting that prevented the identification of chemical objects. Theses in .docx yielded semantically rich SciXML that enabled the additional extraction of associated data. Chemical objects were placed in a data repository, and RDF triples deposited in a triplestore. Data-mining from chemistry e-theses is both desirable and feasible; but the use of PDF, the de facto format standard for deposit in most repositories, prevents the optimal extraction of data for semantic querying. In order to facilitate this, we recommend that universities also require deposition of chemistry e-theses in an XML document format. Further work is required to clarify the complex IPR issues and ensure that they do not become an unwarranted barrier to data extraction and re-use