144,695 research outputs found
Biocatalytic self-assembly cascades
The properties of supramolecular materials are dictated by both kinetic and thermodynamic aspects, providing opportunities to dynamically regulate morphology and function. Herein, we demonstrate time-dependent regulation of supramolecular self-assembly by connected, kinetically competing enzymatic reactions. Starting from Fmoc-tyrosine phosphate and phenylalanine amide in the presence of an amidase and phosphatase, four distinct self-assembling molecules may be formed which each give rise to distinct morphologies (spheres, fibers, tubes/tapes and sheets). By varying the sequence or ratio in which the enzymes are added to mixtures of precursors, these structures can be (transiently) accessed and interconverted. The approach provides insights into dynamic self-assembly using competing pathways that may aid the design of soft nanostructures with tunable dynamic properties and life times
Fuel Efficient Computation in Passive Self-Assembly
In this paper we show that passive self-assembly in the context of the tile
self-assembly model is capable of performing fuel efficient, universal
computation. The tile self-assembly model is a premiere model of self-assembly
in which particles are modeled by four-sided squares with glue types assigned
to each tile edge. The assembly process is driven by positive and negative
force interactions between glue types, allowing for tile assemblies floating in
the plane to combine and break apart over time. We refer to this type of
assembly model as passive in that the constituent parts remain unchanged
throughout the assembly process regardless of their interactions. A
computationally universal system is said to be fuel efficient if the number of
tiles used up per computation step is bounded by a constant. Work within this
model has shown how fuel guzzling tile systems can perform universal
computation with only positive strength glue interactions. Recent work has
introduced space-efficient, fuel-guzzling universal computation with the
addition of negative glue interactions and the use of a powerful non-diagonal
class of glue interactions. Other recent work has shown how to achieve fuel
efficient computation within active tile self-assembly. In this paper we
utilize negative interactions in the tile self-assembly model to achieve the
first computationally universal passive tile self-assembly system that is both
space and fuel-efficient. In addition, we achieve this result using a limited
diagonal class of glue interactions
Optimization of supply diversity for the self-assembly of simple objects in two and three dimensions
The field of algorithmic self-assembly is concerned with the design and
analysis of self-assembly systems from a computational perspective, that is,
from the perspective of mathematical problems whose study may give insight into
the natural processes through which elementary objects self-assemble into more
complex ones. One of the main problems of algorithmic self-assembly is the
minimum tile set problem (MTSP), which asks for a collection of types of
elementary objects (called tiles) to be found for the self-assembly of an
object having a pre-established shape. Such a collection is to be as concise as
possible, thus minimizing supply diversity, while satisfying a set of stringent
constraints having to do with the termination and other properties of the
self-assembly process from its tile types. We present a study of what we think
is the first practical approach to MTSP. Our study starts with the introduction
of an evolutionary heuristic to tackle MTSP and includes results from extensive
experimentation with the heuristic on the self-assembly of simple objects in
two and three dimensions. The heuristic we introduce combines classic elements
from the field of evolutionary computation with a problem-specific variant of
Pareto dominance into a multi-objective approach to MTSP.Comment: Minor typos correcte
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