1,721 research outputs found
Reduction of dynamical biochemical reaction networks in computational biology
Biochemical networks are used in computational biology, to model the static
and dynamical details of systems involved in cell signaling, metabolism, and
regulation of gene expression. Parametric and structural uncertainty, as well
as combinatorial explosion are strong obstacles against analyzing the dynamics
of large models of this type. Multi-scaleness is another property of these
networks, that can be used to get past some of these obstacles. Networks with
many well separated time scales, can be reduced to simpler networks, in a way
that depends only on the orders of magnitude and not on the exact values of the
kinetic parameters. The main idea used for such robust simplifications of
networks is the concept of dominance among model elements, allowing
hierarchical organization of these elements according to their effects on the
network dynamics. This concept finds a natural formulation in tropical
geometry. We revisit, in the light of these new ideas, the main approaches to
model reduction of reaction networks, such as quasi-steady state and
quasi-equilibrium approximations, and provide practical recipes for model
reduction of linear and nonlinear networks. We also discuss the application of
model reduction to backward pruning machine learning techniques
On Nonnormal Asymptotic Behavior of Optimal Solutions of Stochastic Programming Problems: The Parametric Case
Under incomplete information about the parameters of the true distribution of the random coefficients, the optimal solutions to stochastic programs can be only approximated. This paper extends the previous results of the author to the case when strict complementarity conditions need not be assumed
Information geometric methods for complexity
Research on the use of information geometry (IG) in modern physics has
witnessed significant advances recently. In this review article, we report on
the utilization of IG methods to define measures of complexity in both
classical and, whenever available, quantum physical settings. A paradigmatic
example of a dramatic change in complexity is given by phase transitions (PTs).
Hence we review both global and local aspects of PTs described in terms of the
scalar curvature of the parameter manifold and the components of the metric
tensor, respectively. We also report on the behavior of geodesic paths on the
parameter manifold used to gain insight into the dynamics of PTs. Going
further, we survey measures of complexity arising in the geometric framework.
In particular, we quantify complexity of networks in terms of the Riemannian
volume of the parameter space of a statistical manifold associated with a given
network. We are also concerned with complexity measures that account for the
interactions of a given number of parts of a system that cannot be described in
terms of a smaller number of parts of the system. Finally, we investigate
complexity measures of entropic motion on curved statistical manifolds that
arise from a probabilistic description of physical systems in the presence of
limited information. The Kullback-Leibler divergence, the distance to an
exponential family and volumes of curved parameter manifolds, are examples of
essential IG notions exploited in our discussion of complexity. We conclude by
discussing strengths, limits, and possible future applications of IG methods to
the physics of complexity.Comment: review article, 60 pages, no figure
Trajectory optimization for the National Aerospace Plane
The primary objective of this research is to develop an efficient and robust trajectory optimization tool for the optimal ascent problem of the National Aerospace Plane (NASP). This report is organized in the following order to summarize the complete work: Section two states the formulation and models of the trajectory optimization problem. An inverse dynamics approach to the problem is introduced in Section three. Optimal trajectories corresponding to various conditions and performance parameters are presented in Section four. A midcourse nonlinear feedback controller is developed in Section five. Section six demonstrates the performance of the inverse dynamics approach and midcourse controller during disturbances. Section seven discusses rocket assisted ascent which may be beneficial when orbital altitude is high. Finally, Section eight recommends areas of future research
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