Presynaptic adenosine receptor-mediated regulation of diverse thalamocortical short-term plasticity in the mouse whisker pathway

Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits. In “driver” thalamocortical (TC) synaptic populations, STP is dominated by depression during stimulation from rest. However, during ongoing stimulation, lemniscal TC connections onto layer 4 neurons in mouse barrel cortex express variable STP. Each synapse responds to input trains with a distinct pattern of depression or facilitation around its mean steady-state response. As a result, in common with other synaptic populations, lemniscal TC synapses express diverse rather than uniform dynamics, allowing for a rich representation of temporally varying stimuli. Here, we show that this STP diversity is regulated presynaptically. Presynaptic adenosine receptors of the A1R type, but not kainate receptors (KARs), modulate STP behavior. Blocking the receptors does not eliminate diversity, indicating that diversity is related to heterogeneous expression of multiple mechanisms in the pathway from presynaptic calcium influx to neurotransmitter release

The impact of science and technology parks on firms´ product innovation: empirical evidence from Spain

Science and Technology Parks (STP) are one of the most important and extensive innovation policy initiatives introduced in recent years. This work evaluates the impact of STP on firm product innovation in the Spanish context. Spain is less developed than most of the advanced countries, and regional and national governments are prioritizing STP initiatives. The large firm sample for our study is from the Spanish Technological Innovation Survey, provided by the National Statistical Institute. We focus on average treatment effects for firms located in 22 Spanish STP. Our results show that Spanish STP have a strong and positive impact on the probability and amount of product innovation achieved by STP located firms. These results hold for different assumptions about the mechanisms underlying location in a STP.Science and Technology Parks; product innovation; treatment effects; regional development policies.

The Symmetric Teleparallel Gravity

We study symmetric teleparallel (STP) gravity model, in which only spacetime non-metricity is nonzero. First we obtain STP equivalent Einstein-Hilbert Lagrangian and give an approach for a generic solution in terms of only metric tensor. Then we obtain a spherically symmetric static solution to the Einstein's equation in STP space-time and discuss the singularities. Finally, we study a model given by a Lagrangian 4-form quadratic in non-metricity. Thus, we seek Schwarzschild-type solutions because of its observational success and obtain some sets of solutions. Finally, we discuss physical relevance of the solutions.Comment: Paper presented at The 5th Workshop on Quantization, Dualities and Integrable Systems, Pamukkale University, 23-28 January 2006, Denizli, Turke

Spectral and temporal processing in human auditory cortex

Hierarchical processing suggests that spectrally and temporally complex stimuli will evoke more activation than do simple stimuli, particularly in non-primary auditory fields. This hypothesis was tested using two tones, a single frequency tone and a harmonic tone, that were either static or frequency modulated to create four stimuli. We interpret the location of differences in activation by drawing comparisons between fMRI and human cytoarchitectonic data, reported in the same brain space. Harmonic tones produced more activation than single tones in right Heschl's gyrus (HG) and bilaterally in the lateral supratemporal plane (STP). Activation was also greater to frequency-modulated tones than to static tones in these areas, plus in left HG and bilaterally in an anterolateral part of the STP and the superior temporal sulcus. An elevated response magnitude to both frequency-modulated tones was found in the lateral portion of the primary area, and putatively in three surrounding non-primary regions on the lateral STP (one anterior and two posterior to HG). A focal site on the posterolateral STP showed an especially high response to the frequency-modulated harmonic tone. Our data highlight the involvement of both primary and lateral non-primary auditory regions

Farm-gate phosphorus balances and soil phosphorus concentrations on intensive dairy farms in the south-west of Ireland

peer-reviewedThis project was part funded by the European Research and Development Fund under INTERREG IIIB: Green Dairy Project Number 100 and partly by the Dairy Levy. Financial support for post-graduate students involved in this study was provided by the Teagasc Walsh Fellowship Scheme.Phosphorus (P) loss to water is a significant threat to water quality in Ireland. Agriculture is an important source of this P. There is concern about balancing agronomic requirements and environmental protection in regulations prescribing P management on farms. This study examined farm-gate (P) balances and soil test P (STP) concentrations on 21 dairy farms in the south west of Ireland over four years, from 2003 to 2006 inclusive. Stocking density on the farms averaged 2.4 (s.d. = 0.4) livestock units (LU) per ha. Annual mean import of P onto farms was 21.6 (1.9) kg P/ha. Fertilizer P accounted for 47% (0.041), concentrates 35% (0.060) and organic manures 18% (0.034) of imported P. The mean annual P balance per farm was 9.4 (1.2) kg/ha, ranging from –3 to 47 kg/ha and mean P use efficiency was 0.71 (0.05) ranging from 0.24 to 1.37. The mean STP per farm following extraction using Morgan’s solution was 8.15 (2.9) mg/L of soil and ranged from 4.4 (2.2) to 14.7 (6.4) mg/L. There was a positive relationship (R2 = 0.34; P < 0.01) between STP and P balance; farms with a deficit of P tended to have agronomically sub-optimal STP and vice versa. The high between- and withinfarm variation in STP indicates that farmers were either unaware or were not making efficient use of STP results, and consequently there was agronomically sub-optimal soil P status in some fields and potentially environmentally damaging excesses on others (often within one farm). There was considerable potential to improve P management practices on these farms with clear agronomic and environmental benefits.European UnionTeagasc Walsh Fellowship ProgrammeDairy Levy Fun

Cooperative Glutamatergic and Cholinergic Mechanisms Generate Short-Term Modifications of Synaptic Effectiveness in Prepositus Hypoglossi Neurons

To maintain horizontal eye position on a visual target after a saccade, extraocular motoneurons need a persistent (tonic) neural activity, called "eye-position signal," generated by prepositus hypoglossi (PH) neurons. We have shown previously in vitro and in vivo that this neural activity depends, among others mechanisms, on the interplay of glutamatergic transmission and cholinergic synaptically triggered depolarization. Here, we used rat sagittal brainstem slices, including PH nucleus and paramedian pontine reticular formation (PPRF). We made intracellular recordings of PH neurons and studied their synaptic activation from PPRF neurons. Train stimulation of the PPRF area evoked a cholinergic-sustained depolarization of PH neurons that outlasted the stimulus. EPSPs evoked in PH neurons by single pulses applied to the PPRF presented a short-term potentiation (STP) after train stimulation. APV (an NMDA-receptor blocker) or chelerythrine (a protein kinase-C inhibitor) had no effect on the sustained depolarization, but they did block the evoked STP, whereas pirenzepine (an M1 muscarinic antagonist) blocked both the sustained depolarization and the STP of PH neurons. Thus, electrical stimulation of the PPRF area activates both glutamatergic and cholinergic axons terminating in the PH nucleus, the latter producing a sustained depolarization probably involved in the genesis of the persistent neural activity required for eye fixation. M1-receptor activation seems to evoke a STP of PH neurons via NMDA receptors. Such STP could be needed for the stabilization of the neural network involved in the generation of position signals necessary for eye fixation after a saccade