Analysis & Classification of Acute Lymphoblastic Leukemia using KNN Algorithm

The early Detection of leukemia in cancer patients can greatly increase the chances of recovery. The leukemia can be identified by specific tests such as Cytogenetics and Immunophenotyping and morphological cell classification made by hematologist observing blood & marrow microscope images. This Diagnostic methods are costly and time consuming. We propose the use of morphological analysis of microscopic images of leukemic blood cells for the identification purpose, the morphological analysis just requires an image not a blood sample and hence is suitable for low cost and remote diagnostic system . The proposed system firstly individuates in the blood image the leucocytes from the others blood cells, then it select the lymphocyte cells (the ones interested by acute leukemia), it evaluates morphological indexes from those cells and finally it classifies the presence of the leukemia. The segmentation process provides two enhanced images for each blood cell; containing the cytoplasm and the nuclei regions. Unique features for each form of leukemia can then be extracted from the two images and used for identification

Automated Detection of Acute Leukemia using K-mean Clustering Algorithm

Leukemia is a hematologic cancer which develops in blood tissue and triggers rapid production of immature and abnormal shaped white blood cells. Based on statistics it is found that the leukemia is one of the leading causes of death in men and women alike. Microscopic examination of blood sample or bone marrow smear is the most effective technique for diagnosis of leukemia. Pathologists analyze microscopic samples to make diagnostic assessments on the basis of characteristic cell features. Recently, computerized methods for cancer detection have been explored towards minimizing human intervention and providing accurate clinical information. This paper presents an algorithm for automated image based acute leukemia detection systems. The method implemented uses basic enhancement, morphology, filtering and segmenting technique to extract region of interest using k-means clustering algorithm. The proposed algorithm achieved an accuracy of 92.8% and is tested with Nearest Neighbor (KNN) and Naive Bayes Classifier on the data-set of 60 samples.Comment: Presented in ICCCCS 201

Image processing and machine learning in the morphological analysis of blood cells

Introduction: This review focuses on how image processing and machine learning can be useful for the morphological characterization and automatic recognition of cell images captured from peripheral blood smears. Methods: The basics of the 3 core elements (segmentation, quantitative features, and classification) are outlined, and recent literature is discussed. Although red blood cells are a significant part of this context, this study focuses on malignant lymphoid cells and blast cells. Results: There is no doubt that these technologies may help the cytologist to perform efficient, objective, and fast morphological analysis of blood cells. They may also help in the interpretation of some morphological features and may serve as learning and survey tools. Conclusion: Although research is still needed, it is important to define screening strategies to exploit the potential of image-based automatic recognition systems integrated in the daily routine of laboratories along with other analysis methodologies.Peer ReviewedPostprint (published version

Prospects for Theranostics in Neurosurgical Imaging: Empowering Confocal Laser Endomicroscopy Diagnostics via Deep Learning

Confocal laser endomicroscopy (CLE) is an advanced optical fluorescence imaging technology that has the potential to increase intraoperative precision, extend resection, and tailor surgery for malignant invasive brain tumors because of its subcellular dimension resolution. Despite its promising diagnostic potential, interpreting the gray tone fluorescence images can be difficult for untrained users. In this review, we provide a detailed description of bioinformatical analysis methodology of CLE images that begins to assist the neurosurgeon and pathologist to rapidly connect on-the-fly intraoperative imaging, pathology, and surgical observation into a conclusionary system within the concept of theranostics. We present an overview and discuss deep learning models for automatic detection of the diagnostic CLE images and discuss various training regimes and ensemble modeling effect on the power of deep learning predictive models. Two major approaches reviewed in this paper include the models that can automatically classify CLE images into diagnostic/nondiagnostic, glioma/nonglioma, tumor/injury/normal categories and models that can localize histological features on the CLE images using weakly supervised methods. We also briefly review advances in the deep learning approaches used for CLE image analysis in other organs. Significant advances in speed and precision of automated diagnostic frame selection would augment the diagnostic potential of CLE, improve operative workflow and integration into brain tumor surgery. Such technology and bioinformatics analytics lend themselves to improved precision, personalization, and theranostics in brain tumor treatment.Comment: See the final version published in Frontiers in Oncology here: https://www.frontiersin.org/articles/10.3389/fonc.2018.00240/ful

A Survey on Deep Learning in Medical Image Analysis

Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks and provide concise overviews of studies per application area. Open challenges and directions for future research are discussed.Comment: Revised survey includes expanded discussion section and reworked introductory section on common deep architectures. Added missed papers from before Feb 1st 201

Classification of Acute Lymphocytic Leukemic Blood Cell Images using Hybrid CNN-Enhanced Ensemble SVM Models and Machine Learning Classifiers

Acute Lymphocytic Leukemia is a dangerous kind of malignant cancer caused due to the overproduction of white blood cells. The white blood cells in our body are responsible for fighting against infections, if the WBC increases the immunity will decrease and it would lead to serious health conditions. Malignant cancers such as ALL is life threatening if the disease is not diagnosed at an early stage. If a person is suffering from ALL the disease needs to be diagnosed at an early stage before it starts spreading, if it starts spreading the person’s chances of survival would also reduce. Here comes the need of an accurate automated system which would assist the oncologists to diagnose the disease as early as possible. In this paper some of the algorithms that are enhanced to detect and classify ALL are incorporated. In order to classify the Acute Lymphocytic Leukemia a hybrid model has been deployed to improve the accuracy of the diagnosis and it is termed as Hybrid CNN Enhanced Ensemble SVM for the classification of malignancy. Machine Learning classifiers are also used to design the system and it is then compared with enhanced CNN based on the performance metrics

Evaluation of Statistical Features for Medical Image Retrieval

In this paper we present a complete system allowing the classification of medical images in order to detect possible diseases present in them. The proposed method is developed in two distinct stages: calculation of descriptors and their classification. In the first stage we compute a vector of thirty-three statistical features: seven are related to statistics of the first level order, fifteen to that of second level where thirteen are calculated by means of co-occurrence matrices and two with absolute gradient; the last thirteen finally are calculated using run-length matrices. In the second phase, using the descriptors already calculated, there is the actual image classification. Naive Bayes, RBF, Support VectorMa- chine, K-Nearest Neighbor, Random Forest and Random Tree classifiers are used. The results obtained from the proposed system show that the analysis carried out both on textured and on medical images lead to have a high accuracy

A Systematic Survey of Classification Algorithms for Cancer Detection

Cancer is a fatal disease induced by the occurrence of a count of inherited issues and also a count of pathological changes. Malignant cells are dangerous abnormal areas that could develop in any part of the human body, posing a life-threatening threat. To establish what treatment options are available, cancer, also referred as a tumor, should be detected early and precisely. The classification of images for cancer diagnosis is a complex mechanism that is influenced by a diverse of parameters. In recent years, artificial vision frameworks have focused attention on the classification of images as a key problem. Most people currently rely on hand-made features to demonstrate an image in a specific manner. Learning classifiers such as random forest and decision tree were used to determine a final judgment. When there are a vast number of images to consider, the difficulty occurs. Hence, in this paper, weanalyze, review, categorize, and discuss current breakthroughs in cancer detection utilizing machine learning techniques for image recognition and classification. We have reviewed the machine learning approaches like logistic regression (LR), Naïve Bayes (NB), K-nearest neighbors (KNN), decision tree (DT), and Support Vector Machines (SVM)

A survey on automated detection and classification of acute leukemia and WBCs in microscopic blood cells

Leukemia (blood cancer) is an unusual spread of White Blood Cells or Leukocytes (WBCs) in the bone marrow and blood. Pathologists can diagnose leukemia by looking at a person's blood sample under a microscope. They identify and categorize leukemia by counting various blood cells and morphological features. This technique is time-consuming for the prediction of leukemia. The pathologist's professional skills and experiences may be affecting this procedure, too. In computer vision, traditional machine learning and deep learning techniques are practical roadmaps that increase the accuracy and speed in diagnosing and classifying medical images such as microscopic blood cells. This paper provides a comprehensive analysis of the detection and classification of acute leukemia and WBCs in the microscopic blood cells. First, we have divided the previous works into six categories based on the output of the models. Then, we describe various steps of detection and classification of acute leukemia and WBCs, including Data Augmentation, Preprocessing, Segmentation, Feature Extraction, Feature Selection (Reduction), Classification, and focus on classification step in the methods. Finally, we divide automated detection and classification of acute leukemia and WBCs into three categories, including traditional, Deep Neural Network (DNN), and mixture (traditional and DNN) methods based on the type of classifier in the classification step and analyze them. The results of this study show that in the diagnosis and classification of acute leukemia and WBCs, the Support Vector Machine (SVM) classifier in traditional machine learning models and Convolutional Neural Network (CNN) classifier in deep learning models have widely employed. The performance metrics of the models that use these classifiers compared to the others model are higher

Red Deer Optimization with Deep Learning based Robust White Blood Cell Detection and Classification Model

The use of deep learning techniques for White Blood Cell (WBC) classification has garnered significant attention on medical image analysis due to its potential to automate and enhance the accuracy of WBC classification, which is critical for disease diagnosis and infection detection. Convolutional neural networks (CNNs) have revolutionized image analysis tasks, including WBC classification effectively capturing intricate spatial patterns and distinguishing between different cell types. A key advantage of deep learning-based WBC classification is its capability to handle large datasets, enabling models to learn the diverse variations and characteristics of different cell types. This facilitates robust generalization and accurate classification of previously unseen samples. In this paper, a novel approach called Red Deer Optimization with Deep Learning for Robust White Blood Cell Detection and Classification was presented. The proposed model incorporates various components to improve performance and robustness. Image pre-processing involves the utilization of median filtering, while U-Net++ is employed for segmentation, facilitating accurate delineation of WBCs. Feature extraction is performed using the Xception model, which effectively captures informative representations of the WBCs. For classification, BiGRU model is employed, leveraging its ability to model temporal dependencies in the WBC sequences. To optimize the performance of the BiGRU model, the RDO is utilized for parameter tuning, resulting in enhanced accuracy and faster convergence of the deep learning models. The integration of RDO contributes to more reliable detection and classification of WBCs, further improving the overall performance and robustness of the approach. Experimental results demonstrate the superiority of our Red Deer Optimization with deep learning-based approach over traditional methods and standalone deep learning models in achieving robust WBC detection and classification. This research highlights the possibility of combining deep learning techniques with optimization algorithms for improving WBC analysis, offering valuable insights for medical professionals and medical image analysis