Interferometric Synthetic Aperture RADAR and Radargrammetry towards the Categorization of Building Changes

The purpose of this work is the investigation of SAR techniques relying on multi image acquisition for fully automatic and rapid change detection analysis at building level. In particular, the benefits and limitations of a complementary use of two specific SAR techniques, InSAR and radargrammetry, in an emergency context are examined in term of quickness, globality and accuracy. The analysis is performed using spaceborne SAR data

Vision Sensors and Edge Detection

Vision Sensors and Edge Detection book reflects a selection of recent developments within the area of vision sensors and edge detection. There are two sections in this book. The first section presents vision sensors with applications to panoramic vision sensors, wireless vision sensors, and automated vision sensor inspection, and the second one shows image processing techniques, such as, image measurements, image transformations, filtering, and parallel computing

On Improving Generalization of CNN-Based Image Classification with Delineation Maps Using the CORF Push-Pull Inhibition Operator

Deployed image classification pipelines are typically dependent on the images captured in real-world environments. This means that images might be affected by different sources of perturbations (e.g. sensor noise in low-light environments). The main challenge arises by the fact that image quality directly impacts the reliability and consistency of classification tasks. This challenge has, hence, attracted wide interest within the computer vision communities. We propose a transformation step that attempts to enhance the generalization ability of CNN models in the presence of unseen noise in the test set. Concretely, the delineation maps of given images are determined using the CORF push-pull inhibition operator. Such an operation transforms an input image into a space that is more robust to noise before being processed by a CNN. We evaluated our approach on the Fashion MNIST data set with an AlexNet model. It turned out that the proposed CORF-augmented pipeline achieved comparable results on noise-free images to those of a conventional AlexNet classification model without CORF delineation maps, but it consistently achieved significantly superior performance on test images perturbed with different levels of Gaussian and uniform noise

Epigenomic insights into common human disease pathology

The epigenome—the chemical modifications and chromatin-related packaging of the genome—enables the same genetic template to be activated or repressed in different cellular settings. This multi-layered mechanism facilitates cell-type specific function by setting the local sequence and 3D interactive activity level. Gene transcription is further modulated through the interplay with transcription factors and co-regulators. The human body requires this epigenomic apparatus to be precisely installed throughout development and then adequately maintained during the lifespan. The causal role of the epigenome in human pathology, beyond imprinting disorders and specific tumour suppressor genes, was further brought into the spotlight by large-scale sequencing projects identifying that mutations in epigenomic machinery genes could be critical drivers in both cancer and developmental disorders. Abrogation of this cellular mechanism is providing new molecular insights into pathogenesis. However, deciphering the full breadth and implications of these epigenomic changes remains challenging. Knowledge is accruing regarding disease mechanisms and clinical biomarkers, through pathogenically relevant and surrogate tissue analyses, respectively. Advances include consortia generated cell-type specific reference epigenomes, high-throughput DNA methylome association studies, as well as insights into ageing-related diseases from biological ‘clocks’ constructed by machine learning algorithms. Also, 3rd-generation sequencing is beginning to disentangle the complexity of genetic and DNA modification haplotypes. Cell-free DNA methylation as a cancer biomarker has clear clinical utility and further potential to assess organ damage across many disorders. Finally, molecular understanding of disease aetiology brings with it the opportunity for exact therapeutic alteration of the epigenome through CRISPR-activation or inhibition

New advances in vehicular technology and automotive engineering

An automobile was seen as a simple accessory of luxury in the early years of the past century. Therefore, it was an expensive asset which none of the common citizen could afford. It was necessary to pass a long period and waiting for Henry Ford to establish the first plants with the series fabrication. This new industrial paradigm makes easy to the common American to acquire an automobile, either for running away or for working purposes. Since that date, the automotive research grown exponentially to the levels observed in the actuality. Now, the automobiles are indispensable goods; saying with other words, the automobile is a first necessity article in a wide number of aspects of living: for workers to allow them to move from their homes into their workplaces, for transportation of students, for allowing the domestic women in their home tasks, for ambulances to carry people with decease to the hospitals, for transportation of materials, and so on, the list don’t ends. The new goal pursued by the automotive industry is to provide electric vehicles at low cost and with high reliability. This commitment is justified by the oil’s peak extraction on 50s of this century and also by the necessity to reduce the emissions of CO2 to the atmosphere, as well as to reduce the needs of this even more valuable natural resource. In order to achieve this task and to improve the regular cars based on oil, the automotive industry is even more concerned on doing applied research on technology and on fundamental research of new materials. The most important idea to retain from the previous introduction is to clarify the minds of the potential readers for the direct and indirect penetration of the vehicles and the vehicular industry in the today’s life. In this sequence of ideas, this book tries not only to fill a gap by presenting fresh subjects related to the vehicular technology and to the automotive engineering but to provide guidelines for future research. This book account with valuable contributions from worldwide experts of automotive’s field. The amount and type of contributions were judiciously selected to cover a broad range of research. The reader can found the most recent and cutting-edge sources of information divided in four major groups: electronics (power, communications, optics, batteries, alternators and sensors), mechanics (suspension control, torque converters, deformation analysis, structural monitoring), materials (nanotechnology, nanocomposites, lubrificants, biodegradable, composites, structural monitoring) and manufacturing (supply chains). We are sure that you will enjoy this book and will profit with the technical and scientific contents. To finish, we are thankful to all of those who contributed to this book and who made it possible.info:eu-repo/semantics/publishedVersio

SIMULATING SEISMIC WAVE PROPAGATION IN TWO-DIMENSIONAL MEDIA USING DISCONTINUOUS SPECTRAL ELEMENT METHODS

We introduce a discontinuous spectral element method for simulating seismic wave in 2- dimensional elastic media. The methods combine the flexibility of a discontinuous finite element method with the accuracy of a spectral method. The elastodynamic equations are discretized using high-degree of Lagrange interpolants and integration over an element is accomplished based upon the Gauss-Lobatto-Legendre integration rule. This combination of discretization and integration results in a diagonal mass matrix and the use of discontinuous finite element method makes the calculation can be done locally in each element. Thus, the algorithm is simplified drastically. We validated the results of one-dimensional problem by comparing them with finite-difference time-domain method and exact solution. The comparisons show excellent agreement

The interaction of promoter chromatin architecture with the cell cycle regulates transcription activation kinetics

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2013.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references.The relationship between regulatory trans-factors binding a gene's cis-regulatory sequence elements and the transcriptional output of that gene is fundamental to even the most complex network behaviors such as metabolism and differentiation. In eukaryotes, chromatin dynamics on gene promoter sequences is an integral part of regulation, and nucleosome remodeling is often required for transcription activation. Though the transient response of these regulated genes is often important in biological contexts, the role of promoter chromatin architecture in activation kinetics is still unclear. We sought to investigate this relationship as well as possible links to the cell cycle, over which chromatin state experiences dramatic changes. To study the activation kinetics of individual promoters, we develop a method to infer real-time transcription rates from protein expression in single Saccharomyces cerevisiae cells using time-lapse fluorescence microscopy. Comparison between the instantaneous transcription rate and cell-cycle phase in each cell demonstrates the majority of transcriptional variability is due to cell cycle-dependent effects with noisy expression restricted to S/G2/M. This is in stark contrast to current stochastic models of gene expression, most of which do not account for extrinsic effects, and reveals a permissive activation period beginning each S-phase. We then employ a switchable transactivator system to probe transient response kinetics as a function of promoter chromatin architecture at the PHO5 promoter, a well-established model system for chromatin-regulated expression. While we show transactivator binding site affinity and location relative to nucleosomes influences promoter response kinetics, the effect is primarily through architecture-dependent reliance on a dominant, permissive activation period in S/G2. Together with similar observations at synthetic promoters using a chimerical, switchable transactivator, these results suggest the cell cycle has a general role in transcription activation. Based on the timing of the permissive period, DNA replication may play a direct role in transactivation. Thus, in network topologies involving noisy genes and positive feedback, the cell cycle-dependent transcription would lead to distinct predictions between frequently- and non-dividing cells. This work reveals an unappreciated yet dominant role for the cell cycle as a general regulator of transcription in eukaryotes with direct implications in better modeling and design of biological networks.by Christopher J. Zopf.Ph.D

Urban Informatics

This open access book is the first to systematically introduce the principles of urban informatics and its application to every aspect of the city that involves its functioning, control, management, and future planning. It introduces new models and tools being developed to understand and implement these technologies that enable cities to function more efficiently – to become ‘smart’ and ‘sustainable’. The smart city has quickly emerged as computers have become ever smaller to the point where they can be embedded into the very fabric of the city, as well as being central to new ways in which the population can communicate and act. When cities are wired in this way, they have the potential to become sentient and responsive, generating massive streams of ‘big’ data in real time as well as providing immense opportunities for extracting new forms of urban data through crowdsourcing. This book offers a comprehensive review of the methods that form the core of urban informatics from various kinds of urban remote sensing to new approaches to machine learning and statistical modelling. It provides a detailed technical introduction to the wide array of tools information scientists need to develop the key urban analytics that are fundamental to learning about the smart city, and it outlines ways in which these tools can be used to inform design and policy so that cities can become more efficient with a greater concern for environment and equity

Urban Informatics

This open access book is the first to systematically introduce the principles of urban informatics and its application to every aspect of the city that involves its functioning, control, management, and future planning. It introduces new models and tools being developed to understand and implement these technologies that enable cities to function more efficiently – to become ‘smart’ and ‘sustainable’. The smart city has quickly emerged as computers have become ever smaller to the point where they can be embedded into the very fabric of the city, as well as being central to new ways in which the population can communicate and act. When cities are wired in this way, they have the potential to become sentient and responsive, generating massive streams of ‘big’ data in real time as well as providing immense opportunities for extracting new forms of urban data through crowdsourcing. This book offers a comprehensive review of the methods that form the core of urban informatics from various kinds of urban remote sensing to new approaches to machine learning and statistical modelling. It provides a detailed technical introduction to the wide array of tools information scientists need to develop the key urban analytics that are fundamental to learning about the smart city, and it outlines ways in which these tools can be used to inform design and policy so that cities can become more efficient with a greater concern for environment and equity

Urban Informatics

This open access book is the first to systematically introduce the principles of urban informatics and its application to every aspect of the city that involves its functioning, control, management, and future planning. It introduces new models and tools being developed to understand and implement these technologies that enable cities to function more efficiently – to become ‘smart’ and ‘sustainable’. The smart city has quickly emerged as computers have become ever smaller to the point where they can be embedded into the very fabric of the city, as well as being central to new ways in which the population can communicate and act. When cities are wired in this way, they have the potential to become sentient and responsive, generating massive streams of ‘big’ data in real time as well as providing immense opportunities for extracting new forms of urban data through crowdsourcing. This book offers a comprehensive review of the methods that form the core of urban informatics from various kinds of urban remote sensing to new approaches to machine learning and statistical modelling. It provides a detailed technical introduction to the wide array of tools information scientists need to develop the key urban analytics that are fundamental to learning about the smart city, and it outlines ways in which these tools can be used to inform design and policy so that cities can become more efficient with a greater concern for environment and equity