Application of queueing theory in bulk biotech manufacturing

Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division; in conjunction with the Leaders for Global Operations Program at MIT, June 2011."June 2011." Page 42 blank. Cataloged from PDF version of thesis.Includes bibliographical references (p. 41).One of the most challenging problems in Amgen's biological manufacturing facility is adhering to the daily schedule of production tasks. Delays in non-time critical tasks have been traced to temporary workload surges that exceed the production staff's capability to handle them. To quantify this effect, a method for creating an M/M/c queueing model that is specific for bulk biologic manufacturing processes was developed. The model was successfully validated by comparing the predicted results to the historical data for each of the five production shifts. A discussion of how to model different improvement programs is presented, and Amgen-specific data are presented. It was found that across-the-board task duration reductions will reduce the schedule deviation rate by up to 50%. Additionally, it is shown that implementing staff-cross training with other production areas will reduce the schedule deviation rate between 14% and 75%. Implementation aspects of these improvement initiatives in a regulated production environment are discussed.by Michael Donohue.S.M.M.B.A

Improving equipment performance through queueing model applications

Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1995, and Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.Vita.Includes bibliographical references (p. 73-74).by Michael J. Capelle.M.S

Digital imaging technology assessment: Digital document storage project

An ongoing technical assessment and requirements definition project is examining the potential role of digital imaging technology at NASA's STI facility. The focus is on the basic components of imaging technology in today's marketplace as well as the components anticipated in the near future. Presented is a requirement specification for a prototype project, an initial examination of current image processing at the STI facility, and an initial summary of image processing projects at other sites. Operational imaging systems incorporate scanners, optical storage, high resolution monitors, processing nodes, magnetic storage, jukeboxes, specialized boards, optical character recognition gear, pixel addressable printers, communications, and complex software processes

Redundant disk arrays: Reliable, parallel secondary storage

During the past decade, advances in processor and memory technology have given rise to increases in computational performance that far outstrip increases in the performance of secondary storage technology. Coupled with emerging small-disk technology, disk arrays provide the cost, volume, and capacity of current disk subsystems, by leveraging parallelism, many times their performance. Unfortunately, arrays of small disks may have much higher failure rates than the single large disks they replace. Redundant arrays of inexpensive disks (RAID) use simple redundancy schemes to provide high data reliability. The data encoding, performance, and reliability of redundant disk arrays are investigated. Organizing redundant data into a disk array is treated as a coding problem. Among alternatives examined, codes as simple as parity are shown to effectively correct single, self-identifying disk failures

Simulation and analysis of adaptive routing and flow control in wide area communication networks

This thesis presents the development of new simulation and analytic models for the performance analysis of wide area communication networks. The models are used to analyse adaptive routing and flow control in fully connected circuit switched and sparsely connected packet switched networks. In particular the performance of routing algorithms derived from the L(_R-I) linear learning automata model are assessed for both types of network. A novel architecture using the INMOS Transputer is constructed for simulation of both circuit and packet switched networks in a loosely coupled multi- microprocessor environment. The network topology is mapped onto an identically configured array of processing centres to overcome the processing bottleneck of conventional Von Neumann architecture machines. Previous analytic work in circuit switched work is extended to include both asymmetrical networks and adaptive routing policies. In the analysis of packet switched networks analytic models of adaptive routing and flow control are integrated to produce a powerful, integrated environment for performance analysis The work concludes that routing algorithms based on linear learning automata have significant potential in both fully connected circuit switched networks and sparsely connected packet switched networks

Data systems elements technology assessment and system specifications, issue no. 1

The ability to satisfy the objectives of future NASA Office of Applications Programs is dependent on technology advances in a number of areas of data systems. The technology of end-to-end data systems (space generator elements through ground processing, dissemination, and presentation, is examined in terms of state of the art, trends, and projected developments in the 1980 to 1985 timeframe. Capability is considered in terms of elements that are either commercially available or that can be implemented from commercially available components with minimal development

C-MOS array design techniques: SUMC multiprocessor system study

The current capabilities of LSI techniques for speed and reliability, plus the possibilities of assembling large configurations of LSI logic and storage elements, have demanded the study of multiprocessors and multiprocessing techniques, problems, and potentialities. Evaluated are three previous systems studies for a space ultrareliable modular computer multiprocessing system, and a new multiprocessing system is proposed that is flexibly configured with up to four central processors, four 1/0 processors, and 16 main memory units, plus auxiliary memory and peripheral devices. This multiprocessor system features a multilevel interrupt, qualified S/360 compatibility for ground-based generation of programs, virtual memory management of a storage hierarchy through 1/0 processors, and multiport access to multiple and shared memory units

Online Simulation in Semiconductor Manufacturing

In semiconductor manufacturing discrete event simulation systems are quite established to support multiple planning decisions. During the recent years, the productivity is increasing by using simulation methods. The motivation for this thesis is to use online simulation not only for planning decisions, but also for a wide range of operational decisions. Therefore an integrated online simulation system for short term forecasting has been developed. The production environment is a mature high mix logic wafer fab. It has been selected because of its vast potential for performance improvement. In this thesis several aspects of online simulation will be addressed: The first aspect is the implementation of an online simulation system in semiconductor manufacturing. The general problem is to achieve a high speed, a high level of detail, and a high forecast accuracy. To resolve these problems, an online simulation system has been created. The simulation model has a high level of detail. It is created automatically from underling fab data. To create such a simulation model from fab data, additional problems related to the underlying data arise. The major parts are the data access, the data integration, and the data quality. These problems have been solved by using an integrated data model with several data extraction, data transformation, and data cleaning steps. The second aspect is related to the accuracy of online simulation. The overall problem is to increase the forecast horizon, increase the level of detail of the forecast and reduce the forecast error. To provide useful forecast results, the simulation model contains a high level of modeling details and a proper initialization. The influences on the forecast quality will be analyzed. The results show that the simulation forecast accuracy achieves good quality to predict future fab performance. The last aspect is to find ways to use simulation forecast results to improve the fab performance. Numerous applications have been identified. For each application a description is available. It contains the requirements of such a forecast, the decision variables, and background information. An application example shows, where a performance problem exists and how online simulation is able to resolve it. To further enhance the real time capability of online simulation, a major part is to investigate new ways to connect the simulation model with the wafer fab. For fab driven simulation, the simulation model and the real wafer fab run concurrently. The wafer fab provides several events to update the simulation during runtime. So the model is always synchronized with the real fab. It becomes possible to start a simulation run in real time. There is no further delay for data extraction, data transformation and model creation. A prototype for a single work center has been implemented to show the feasibility

Data systems elements technology assessment and system specifications, issue no. 2

The ability to satisfy the objectives of future NASA Office of Applications programs is dependent on technology advances in a number of areas of data systems. The hardware and software technology of end-to-end systems (data processing elements through ground processing, dissemination, and presentation) are examined in terms of state of the art, trends, and projected developments in the 1980 to 1985 timeframe. Capability is considered in terms of elements that are either commercially available or that can be implemented from commercially available components with minimal development