HIERARCHICAL LEARNING OF DISCRIMINATIVE FEATURES AND CLASSIFIERS FOR LARGE-SCALE VISUAL RECOGNITION

Enabling computers to recognize objects present in images has been a long standing but tremendously challenging problem in the field of computer vision for decades. Beyond the difficulties resulting from huge appearance variations, large-scale visual recognition poses unprecedented challenges when the number of visual categories being considered becomes thousands, and the amount of images increases to millions. This dissertation contributes to addressing a number of the challenging issues in large-scale visual recognition. First, we develop an automatic image-text alignment method to collect massive amounts of labeled images from the Web for training visual concept classifiers. Specif- ically, we first crawl a large number of cross-media Web pages containing Web images and their auxiliary texts, and then segment them into a collection of image-text pairs. We then show that near-duplicate image clustering according to visual similarity can significantly reduce the uncertainty on the relatedness of Web images’ semantics to their auxiliary text terms or phrases. Finally, we empirically demonstrate that ran- dom walk over a newly proposed phrase correlation network can help to achieve more precise image-text alignment by refining the relevance scores between Web images and their auxiliary text terms. Second, we propose a visual tree model to reduce the computational complexity of a large-scale visual recognition system by hierarchically organizing and learning the classifiers for a large number of visual categories in a tree structure. Compared to previous tree models, such as the label tree, our visual tree model does not require training a huge amount of classifiers in advance which is computationally expensive. However, we experimentally show that the proposed visual tree achieves results that are comparable or even better to other tree models in terms of recognition accuracy and efficiency. Third, we present a joint dictionary learning (JDL) algorithm which exploits the inter-category visual correlations to learn more discriminative dictionaries for image content representation. Given a group of visually correlated categories, JDL simul- taneously learns one common dictionary and multiple category-specific dictionaries to explicitly separate the shared visual atoms from the category-specific ones. We accordingly develop three classification schemes to make full use of the dictionaries learned by JDL for visual content representation in the task of image categoriza- tion. Experiments on two image data sets which respectively contain 17 and 1,000 categories demonstrate the effectiveness of the proposed algorithm. In the last part of the dissertation, we develop a novel data-driven algorithm to quantitatively characterize the semantic gaps of different visual concepts for learning complexity estimation and inference model selection. The semantic gaps are estimated directly in the visual feature space since the visual feature space is the common space for concept classifier training and automatic concept detection. We show that the quantitative characterization of the semantic gaps helps to automatically select more effective inference models for classifier training, which further improves the recognition accuracy rates

Network Analysis with Stochastic Grammars

Digital forensics requires significant manual effort to identify items of evidentiary interest from the ever-increasing volume of data in modern computing systems. One of the tasks digital forensic examiners conduct is mentally extracting and constructing insights from unstructured sequences of events. This research assists examiners with the association and individualization analysis processes that make up this task with the development of a Stochastic Context -Free Grammars (SCFG) knowledge representation for digital forensics analysis of computer network traffic. SCFG is leveraged to provide context to the low-level data collected as evidence and to build behavior profiles. Upon discovering patterns, the analyst can begin the association or individualization process to answer criminal investigative questions. Three contributions resulted from this research. First , domain characteristics suitable for SCFG representation were identified and a step -by- step approach to adapt SCFG to novel domains was developed. Second, a novel iterative graph-based method of identifying similarities in context-free grammars was developed to compare behavior patterns represented as grammars. Finally, the SCFG capabilities were demonstrated in performing association and individualization in reducing the suspect pool and reducing the volume of evidence to examine in a computer network traffic analysis use case

Context-Independent Task Knowledge for Neurosymbolic Reasoning in Cognitive Robotics

One of the current main goals of artificial intelligence and robotics research is the creation of an artificial assistant which can have flexible, human like behavior, in order to accomplish everyday tasks. A lot of what is context-independent task knowledge to the human is what enables this flexibility at multiple levels of cognition. In this scope the author analyzes how to acquire, represent and disambiguate symbolic knowledge representing context-independent task knowledge, abstracted from multiple instances: this thesis elaborates the incurred problems, implementation constraints, current state-of-the-art practices and ultimately the solutions newly introduced in this scope. The author specifically discusses acquisition of context-independent task knowledge from large amounts of human-written texts and their reusability in the robotics domain; the acquisition of knowledge on human musculoskeletal dependencies constraining motion which allows a better higher level representation of observed trajectories; the means of verbalization of partial contextual and instruction knowledge, increasing interaction possibilities with the human as well as contextual adaptation. All the aforementioned points are supported by evaluation in heterogeneous setups, to bring a view on how to make optimal use of statistical & symbolic applications (i.e. neurosymbolic reasoning) in cognitive robotics. This work has been performed to enable context-adaptable artificial assistants, by bringing together knowledge on what is usually regarded as context-independent task knowledge

Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment

Transcriptomics data are relevant to address a number of challenges in Toxicogenomics (TGx). After careful planning of exposure conditions and data preprocessing, the TGx data can be used in predictive toxicology, where more advanced modelling techniques are applied. The large volume of molecular profiles produced by omics-based technologies allows the development and application of artificial intelligence (AI) methods in TGx. Indeed, the publicly available omics datasets are constantly increasing together with a plethora of different methods that are made available to facilitate their analysis, interpretation and the generation of accurate and stable predictive models. In this review, we present the state-of-the-art of data modelling applied to transcriptomics data in TGx. We show how the benchmark dose (BMD) analysis can be applied to TGx data. We review read across and adverse outcome pathways (AOP) modelling methodologies. We discuss how network-based approaches can be successfully employed to clarify the mechanism of action (MOA) or specific biomarkers of exposure. We also describe the main AI methodologies applied to TGx data to create predictive classification and regression models and we address current challenges. Finally, we present a short description of deep learning (DL) and data integration methodologies applied in these contexts. Modelling of TGx data represents a valuable tool for more accurate chemical safety assessment. This review is the third part of a three-article series on Transcriptomics in Toxicogenomics

Transcriptomics in Toxicogenomics, Part III : Data Modelling for Risk Assessment

Transcriptomics data are relevant to address a number of challenges in Toxicogenomics (TGx). After careful planning of exposure conditions and data preprocessing, the TGx data can be used in predictive toxicology, where more advanced modelling techniques are applied. The large volume of molecular profiles produced by omics-based technologies allows the development and application of artificial intelligence (AI) methods in TGx. Indeed, the publicly available omics datasets are constantly increasing together with a plethora of different methods that are made available to facilitate their analysis, interpretation and the generation of accurate and stable predictive models. In this review, we present the state-of-the-art of data modelling applied to transcriptomics data in TGx. We show how the benchmark dose (BMD) analysis can be applied to TGx data. We review read across and adverse outcome pathways (AOP) modelling methodologies. We discuss how network-based approaches can be successfully employed to clarify the mechanism of action (MOA) or specific biomarkers of exposure. We also describe the main AI methodologies applied to TGx data to create predictive classification and regression models and we address current challenges. Finally, we present a short description of deep learning (DL) and data integration methodologies applied in these contexts. Modelling of TGx data represents a valuable tool for more accurate chemical safety assessment. This review is the third part of a three-article series on Transcriptomics in Toxicogenomics.Peer reviewe

Efficient reconstruction of prior austenite grains in steel from etched light optical micrographs using deep learning and annotations from correlative microscopy

The high-temperature austenite phase is the initial state of practically all technologically relevant hot forming and heat treatment operations in steel processing. The phenomena occurring in austenite, such as recrystallization or grain growth, can have a decisive influence on the subsequent properties of the material. After the hot forming or heat treatment process, however, the austenite transforms into other microstructural constituents and information on the prior austenite morphology are no longer directly accessible. There are established methods available for reconstructing former austenite grain boundaries via metallographic etching or electron backscatter diffraction (EBSD) which both exhibit shortcomings. While etching is often difficult to reproduce and strongly depend on the investigated steel’s alloying concept, EBSD acquisition and reconstruction is rather time-consuming. But in fact, though, light optical micrographs of steels contrasted with conventional Nital etchant also contain information about the former austenite grains. However, relevant features are not directly apparent or accessible with conventional segmentation approaches. This work presents a deep learning (DL) segmentation of prior austenite grains (PAG) from Nital etched light optical micrographs. The basis for successful segmentation is a correlative characterization from EBSD, light and scanning electron microscopy to specify the ground truth required for supervised learning. The DL model shows good and robust segmentation results. While the intersection over union of 70% does not fully reflect the model performance due to the inherent uncertainty in PAG estimation, a mean error of 6.1% in mean grain size derived from the segmentation clearly shows the high quality of the result

Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data

Abstract Managing, processing and understanding big healthcare data is challenging, costly and demanding. Without a robust fundamental theory for representation, analysis and inference, a roadmap for uniform handling and analyzing of such complex data remains elusive. In this article, we outline various big data challenges, opportunities, modeling methods and software techniques for blending complex healthcare data, advanced analytic tools, and distributed scientific computing. Using imaging, genetic and healthcare data we provide examples of processing heterogeneous datasets using distributed cloud services, automated and semi-automated classification techniques, and open-science protocols. Despite substantial advances, new innovative technologies need to be developed that enhance, scale and optimize the management and processing of large, complex and heterogeneous data. Stakeholder investments in data acquisition, research and development, computational infrastructure and education will be critical to realize the huge potential of big data, to reap the expected information benefits and to build lasting knowledge assets. Multi-faceted proprietary, open-source, and community developments will be essential to enable broad, reliable, sustainable and efficient data-driven discovery and analytics. Big data will affect every sector of the economy and their hallmark will be ‘team science’.http://deepblue.lib.umich.edu/bitstream/2027.42/134522/1/13742_2016_Article_117.pd