5,431 research outputs found
Hemodynamics of Cerebral Aneurysms: Computational Analyses of Aneurysm Progress and Treatment
The progression of a cerebral aneurysm involves degenerative arterial wall remodeling. Various hemodynamic parameters are suspected to be major mechanical factors related to the genesis and progression of vascular diseases. Flow alterations caused by the insertion of coils and stents for interventional aneurysm treatment may affect the aneurysm embolization process. Therefore, knowledge of hemodynamic parameters may provide physicians with an advanced understanding of aneurysm progression and rupture, as well as the effectiveness of endovascular treatments. Progress in medical imaging and information technology has enabled the prediction of flow fields in the patient-specific blood vessels using computational analysis. In this paper, recent computational hemodynamic studies on cerebral aneurysm initiation, progress, and rupture are reviewed. State-of-the-art computational aneurysmal flow analyses after coiling and stenting are also summarized. We expect the computational analysis of hemodynamics in cerebral aneurysms to provide valuable information for planning and follow-up decisions for treatment
The 'Sphere': A Dedicated Bifurcation Aneurysm Flow-Diverter Device.
We present flow-based results from the early stage design cycle, based on computational modeling, of a prototype flow-diverter device, known as the 'Sphere', intended to treat bifurcation aneurysms of the cerebral vasculature. The device is available in a range of diameters and geometries and is constructed from a single loop of NITINOL(®) wire. The 'Sphere' reduces aneurysm inflow by means of a high-density, patterned, elliptical surface that partially occludes the aneurysm neck. The device is secured in the healthy parent vessel by two armatures in the shape of open loops, resulting in negligible disruption of parent or daughter vessel flow. The device is virtually deployed in six anatomically accurate bifurcation aneurysms: three located at the Basilar tip and three located at the terminus bifurcation of the Internal Carotid artery (at the meeting of the middle cerebral and anterior cerebral arteries). Both steady state and transient flow simulations reveal that the device presents with a range of aneurysm inflow reductions, with mean flow reductions falling in the range of 30.6-71.8% across the different geometries. A significant difference is noted between steady state and transient simulations in one geometry, where a zone of flow recirculation is not captured in the steady state simulation. Across all six aneurysms, the device reduces the WSS magnitude within the aneurysm sac, resulting in a hemodynamic environment closer to that of a healthy vessel. We conclude from extensive CFD analysis that the 'Sphere' device offers very significant levels of flow reduction in a number of anatomically accurate aneurysm sizes and locations, with many advantages compared to current clinical cylindrical flow-diverter designs. Analysis of the device's mechanical properties and deployability will follow in future publications
Comparison of existing aneurysm models and their path forward
The two most important aneurysm types are cerebral aneurysms (CA) and
abdominal aortic aneurysms (AAA), accounting together for over 80\% of all
fatal aneurysm incidences. To minimise aneurysm related deaths, clinicians
require various tools to accurately estimate its rupture risk. For both
aneurysm types, the current state-of-the-art tools to evaluate rupture risk are
identified and evaluated in terms of clinical applicability. We perform a
comprehensive literature review, using the Web of Science database. Identified
records (3127) are clustered by modelling approach and aneurysm location in a
meta-analysis to quantify scientific relevance and to extract modelling
patterns and further assessed according to PRISMA guidelines (179 full text
screens). Beside general differences and similarities of CA and AAA, we
identify and systematically evaluate four major modelling approaches on
aneurysm rupture risk: finite element analysis and computational fluid dynamics
as deterministic approaches and machine learning and assessment-tools and
dimensionless parameters as stochastic approaches. The latter score highest in
the evaluation for their potential as clinical applications for rupture
prediction, due to readiness level and user friendliness. Deterministic
approaches are less likely to be applied in a clinical environment because of
their high model complexity. Because deterministic approaches consider
underlying mechanism for aneurysm rupture, they have improved capability to
account for unusual patient-specific characteristics, compared to stochastic
approaches. We show that an increased interdisciplinary exchange between
specialists can boost comprehension of this disease to design tools for a
clinical environment. By combining deterministic and stochastic models,
advantages of both approaches can improve accessibility for clinicians and
prediction quality for rupture risk.Comment: 46 pages, 5 figure
Immersed boundary method predictions of shear stresses for different flow topologies occuring in cerebral aneurysms
A volume-penalizing immersed boundary method is presented that facilitates the computation of incompressible fluid flow in complex flow domains. We apply this method to simulate the flow in cerebral aneurysms, and focus on the accuracy with which the flow field and the corresponding shear stress field are computed. The method is applied to laminar, incompressible flow in curved cylindrical vessels and in a model aneurysm. The time-dependent shear stress distributions over the vessel walls are visualized and interpreted in terms of the flow fields that develop. We compute shear stress levels at two different Reynolds numbers, corresponding to a steady and an unsteady flow. In the latter situation strong fluctuations in the shear stress are observed, that may be connected to raised risk-levels of aneurysm rupture
Hypertension as a Determining Factor in the Rupture of Intracranial Aneurysms, Diagnosed by 64-MDCT Angiography
Background: To determine a correlation between risk factors and the rupture of intracranial aneurysms. Methods: A cross-sectional study of 29 patients with a saccular intracranial aneurysm was obtained using consecutive sampling and examination of 64-MDCT angiography. Bivariate statistical analysis using Fisher's exact test was arranged using cross-tabulation to determine the correlation between each risk factor of age, sex, hypertension, and smoking with the occurrence of ruptured intracranial aneurysms. Results: The highest incidence of ruptured intracranial aneurysms were in patients aged <60 years (70%), male (75%), experienced hypertension (85%), and were smokers (85.7%). Only the risk factor of hypertension had a correlation with the occurrence of a ruptured intracranial aneurysm (p < 0.05). The prevalence ratio of age and sex were 1.0 and 0.9, whereas hypertension and smoking were 2.6 and 1.3. Conclusions: The risk factor of hypertension leading to a ruptured intracranial aneurysm was 2.6 times higher than non-hypertensive patients, and as such hypertension is a risk factor associated with the occurrence of ruptured intracranial aneurysm
An automated multiscale ensemble simulation approach for vascular blood flow
Cerebrovascular diseases such as brain aneurysms are a primary cause of adult disability. The flow dynamics in brain arteries, both during periods of rest and increased activity, are known to be a major factor in the risk of aneurysm formation and rupture. The precise relation is however still an open field of investigation. We present an automated ensemble simulation method for modelling cerebrovascular blood flow under a range of flow regimes. By automatically constructing and performing an ensemble of multiscale simulations, where we unidirectionally couple a 1D solver with a 3D lattice-Boltzmann code, we are able to model the blood flow in a patient artery over a range of flow regimes. We apply the method to a model of a middle cerebral artery, and find that this approach helps us to fine-tune our modelling techniques, and opens up new ways to investigate cerebrovascular flow properties.This work has received funding from the CRESTA project within the EC-FP7 (ICT-2011.9.13) under Grant Agreements no. 287703, and from EPSRC Grants EP/I017909/1 (www.2020science.net) and EP/I034602/1
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Estimated pretreatment hemodynamic prognostic factors of aneurysm recurrence after endovascular embolization.
BACKGROUND:Hemodynamic factors play important roles in aneurysm recurrence after endovascular treatment. OBJECTIVE:Predicting the risk of recurrence by hemodynamic analysis using an untreated aneurysm model is important because such prediction is required before treatment. METHODS:We retrospectively analyzed hemodynamic factors associated with aneurysm recurrence from pretreatment models of five recurrent and five stable posterior communicating artery (Pcom) aneurysms with no significant differences in aneurysm volume, coil packing density, or sizes of the dome, neck, or Pcom. Hemodynamic factors of velocity ratio, flow rate, pressure ratio, and wall shear stress were investigated. RESULTS:Among the hemodynamic factors investigated, velocity ratio and flow rate of the Pcom showed significant differences between the recurrence group and stable group (0.630 ± 0.062 and 0.926 ± 0.051, P= 0.016; 56.4 ± 8.9 and 121.6 ± 6.7, P= 0.008, respectively). CONCLUSIONS:Our results suggest that hemodynamic factors may be associated with aneurysm recurrence among Pcom aneurysms. Velocity and flow rate in the Pcom may be a pretreatment prognostic factor for aneurysm recurrence after endovascular treatment
Effects of blood flow patent and cross-sectional area on hemodynamic into patient-specific cerebral aneurysm via fluid-structure interaction method : A review
Fluid-structure interaction (FSI) simulation is carried out to investigate the blood flow analysis in different patient-specific cerebral aneurysms. In this study, we reviewed the studies done on the numerical simulation of blood flow in patient-specific aneurysm by using FSI analysis methods. Based on these studies, the wall shear stress (WSS) plays an important role in the development, growth, and rupture of the cerebral aneurysm. Prediction of the hemodynamic forces near the aneurysmal site helps to understand the formation and rupture of the aneurysms better. Then most of the aneurysms studied are located in the middle cerebral artery (MCA). In the existing considered, many researchers are more familiar with the experimental method in studies of blood flow through cerebral aneurysm compared to the numerical method. Nevertheless, numerical simulation of patient-specific cerebral aneurysms can give a better understanding and clear visualization of WSS distribution and fluid flow pattern in the aneurysm region
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