Computational neurorehabilitation: modeling plasticity and learning to predict recovery

Despite progress in using computational approaches to inform medicine and neuroscience in the last 30 years, there have been few attempts to model the mechanisms underlying sensorimotor rehabilitation. We argue that a fundamental understanding of neurologic recovery, and as a result accurate predictions at the individual level, will be facilitated by developing computational models of the salient neural processes, including plasticity and learning systems of the brain, and integrating them into a context specific to rehabilitation. Here, we therefore discuss Computational Neurorehabilitation, a newly emerging field aimed at modeling plasticity and motor learning to understand and improve movement recovery of individuals with neurologic impairment. We first explain how the emergence of robotics and wearable sensors for rehabilitation is providing data that make development and testing of such models increasingly feasible. We then review key aspects of plasticity and motor learning that such models will incorporate. We proceed by discussing how computational neurorehabilitation models relate to the current benchmark in rehabilitation modeling – regression-based, prognostic modeling. We then critically discuss the first computational neurorehabilitation models, which have primarily focused on modeling rehabilitation of the upper extremity after stroke, and show how even simple models have produced novel ideas for future investigation. Finally, we conclude with key directions for future research, anticipating that soon we will see the emergence of mechanistic models of motor recovery that are informed by clinical imaging results and driven by the actual movement content of rehabilitation therapy as well as wearable sensor-based records of daily activity

Themes and Participants’ Role in Online Health Discussion: Evidence From Reddit

Health-related topics are discussed widely on different social networking sites. These discussions and their related aspects can reveal significant insights and patterns that are worth studying and understanding. In this dissertation, we explore the patterns of mandatory and voluntary vaccine online discussions including the topics discussed, the words correlated with each of them, and the sentiment expressed. Moreover, we explore the role opinion leaders play in the health discussion and their impact on participation in a particular discussion. Opinion leaders are determined, and their impact on discussion participation is differentiated based on their different characteristics such as their connections and locations in the social network, their content, and their sentiment. We apply social network analysis, topic modeling, sentiment analysis, machine learning, econometric analysis, and other techniques to analyze the collected data from Reddit. The results of our analyses show that sentiment is an important factor in health discussion, and it varies between different types of discussions. In addition, we identified the main topics discussed for each vaccine. Furthermore, the results of our study found that global opinion leaders have more influence compared to local opinion leaders in elevating the health discussion. Our study has important theoretical and practical implications

Temperament in the Classroom

Variance in academic performance that persists when situational variables are held constant suggests that whether students fail or thrive depends not only on circumstance, but also on relatively stable individual differences in how children respond to circumstance. More academically talented children generally outperform their less able peers, but much less is known about how traits unrelated to general intelligence influence academic outcomes. This paper addresses several related questions: What insights can be gleaned from historical interest in the role of temperament in the classroom? What does recent empirical research say about the specific dimensions of temperament most important to successful academic performance? In particular, which aspects of temperament most strongly influence school readiness, academic achievement, and educational attainment? What factors mediate and moderate associations between temperament and academic outcomes? What progress has been made in deliberately cultivating aspects of temperament that matter most to success in school? And, finally, for researchers keenly interested in better understanding how and why temperament influences academic success, in which direction does future progress lie?

Predictive Modeling in Action: How 'Virtual Wards' Help High-Risk Patients Receive Hospital Care at Home

Describes a program to reduce hospitalizations by providing multidisciplinary case management and coordinated preventive care at home to chronic disease patients found to be at risk of emergency hospitalization by predictive modeling. Outlines challenges

Functional Magnetic Resonance Imaging of Semantic Memory as a Presymptomatic Biomarker of Alzheimer’s Disease Risk

Extensive research efforts have been directed toward strategies for predicting risk of developing Alzheimer\u27s disease (AD) prior to the appearance of observable symptoms. Existing approaches for early detection of AD vary in terms of their efficacy, invasiveness, and ease of implementation. Several non-invasive magnetic resonance imaging strategies have been developed for predicting decline in cognitively healthy older adults. This review will survey a number of studies, beginning with the development of a famous name discrimination task used to identify neural regions that participate in semantic memory retrieval and to test predictions of several key theories of the role of the hippocampus in memory. This task has revealed medial temporal and neocortical contributions to recent and remote memory retrieval, and it has been used to demonstrate compensatory neural recruitment in older adults, apolipoprotein E ε4 carriers, and amnestic mild cognitive impairment patients. Recently, we have also found that the famous name discrimination task provides predictive value for forecasting episodic memory decline among asymptomatic older adults. Other studies investigating the predictive value of semantic memory tasks will also be presented. We suggest several advantages associated with the use of semantic processing tasks, particularly those based on person identification, in comparison to episodic memory tasks to study AD risk. Future directions for research and potential clinical uses of semantic memory paradigms are also discussed. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease

Predictive models for charitable giving using machine learning techniques

Private giving represents more than three fourths of all U.S. charitable donations, about 2% of total Gross Domestic Product (GDP). Private giving is a significant factor in funding the nonprofit sector of the U.S. economy, which accounts for more than 10% of total GDP. Despite the abundance of data available through tax forms and other sources, it is unclear which factors influence private donation, and a reliable predictive mechanism remains elu- sive. This study aims to develop predictive models to accurately estimate future charitable giving based on a set of potentially influential factors. We have selected several factors, including unemployment rate, household income, poverty level, population, sex, age, ethnic- ity, education level, and number of vehicles per household. This study sheds light on the relationship between donation and these variables. We use Stepwise Regression to identify the most influential variables among the available variables, based on which predictive mod- els are developed. Multiple Linear Regression (MLR) and machine learning techniques, including Artificial Neural Networks (ANN) and Support Vector Regression (SVR) are used to develop the predictive models. The results suggest that population, education level, and the amount of charitable giving in the previous year are the most significant, independent variables. We propose three predictive models (MLR, ANN, and SVR) and validate them using 10-fold cross-validation method, then evaluate the performance using 9 different mea- suring criteria. All three models are capable of predicting the amount of future donations in a given region with good accuracy. Based on the evaluation criteria, using a test data set, ANN outperforms SVR and MLR in predicting the amount of charitable giving in the following year

Point of view on outcome prediction models in post-stroke motor recovery

Stroke is a leading cause of disability worldwide which can cause significant and persistent upper limb (UL) impairment. It is difficult to predict UL motor recovery after stroke and to forecast the expected outcomes of rehabilitation interventions during the acute and subacute phases when using clinical data alone. Accurate prediction of response to treatment could allow for more timely and targeted interventions, thereby improving recovery, resource allocation, and reducing the economic impact of post-stroke disability. Initial motor impairment is currently the strongest predictor of post-stroke motor recovery. Despite significant progress, current prediction models could be refined with additional predictors, and an emphasis on the time dependency of patient-specific predictions of UL recovery profiles. In the current paper a panel of experts provide their opinion on additional predictors and aspects of the literature that can help advance stroke outcome prediction models. Potential strategies include close attention to post-stroke data collection timeframes and adoption of individual-computerized modeling methods connected to a patient’s health record. These models should account for the non-linear and the variable recovery pattern of spontaneous neurological recovery. Additionally, input data should be extended to include cognitive, genomic, sensory, neural injury, and function measures as additional predictors of recovery. The accuracy of prediction models may be further improved by including standardized measures of outcome. Finally, we consider the potential impact of refined prediction models on healthcare costs

Disposition of youth in predicting sustainable development goals using the Neuro - fuzzy and random forest algorithms

This paper evaluates the inclination of Asian youth regarding the achievement of Sustainable Development Goals (SDGs). As the young population of a country holds the key to its future development, the authors of this study aim to provide evidence of the successful application of machine learning techniques to highlight their opinions about a sustainable future. This study’s timing is critical due to rapid developments in technology which are highlighting gaps between policy and the actual aspirations of citizens. Several studies indicate the superior predictive capabilities of neuro-fuzzy techniques. At the same time, Random Forest is gaining popularity as an advanced prediction and classification tool. This study aims to build on the previous research and compare the predictive accuracy of the adaptive neuro-fuzzy inference system (ANFIS) and Random Forest models for three categories of SGDs. The study also aims to explore possible differences of opinion regarding the importance of these categories among Asian and Serbian youth. The data used in this study were collected from 425 youth respondents in India. The results of data analysis show that ANFIS is better at predicting SDGs than the Random Forest model. The SDG preference among Asian and Serbian youth was found to be highest for the environmental pillar, followed by the social and economic pillars. This paper makes both a theoretical and a practical contribution to deepening understanding of the predictive power of the two models and to devising policies for attaining the SDGs by 2030

Faculty Publications 2018-2019

The production of scholarly research continues to be one of the primary missions of the ILR School. During a typical academic year, ILR faculty members published or had accepted for publication over 25 books, edited volumes, and monographs, 170 articles and chapters in edited volumes, numerous book reviews. In addition, a large number of manuscripts were submitted for publication, presented at professional association meetings, or circulated in working paper form. Our faculty\u27s research continues to find its way into the very best industrial relations, social science and statistics journal

Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: A Prospective Resting-State fMRI Study

Functional magnetic resonance imaging (fMRI) studies have demonstrated alterations during task-induced brain activation in spinal cord injury (SCI) patients. The interruption to structural integrity of the spinal cord and the resultant disrupted flow of bidirectional communication between the brain and the spinal cord might contribute to the observed dynamic reorganization (neural plasticity). However, the effect of SCI on brain resting-state connectivity patterns remains unclear. We undertook a prospective resting-state fMRI (rs-fMRI) study to explore changes to cortical activation patterns following SCI. With institutional review board approval, rs-fMRI data was obtained in eleven patients with complete cervical SCI (\u3e2 years post injury) and nine age-matched controls. The data was processed using the Analysis of Functional Neuroimages software. Region of interest (ROI) based analysis was performed to study changes in the sensorimotor network using pre- and post-central gyri as seed regions. Two-sampled t-test was carried out to check for significant differences between the two groups. SCI patients showed decreased functional connectivity in motor and sensory cortical regions when compared to controls. The decrease was noted in ipsilateral, contralateral, and interhemispheric regions for left and right precentral ROIs. Additionally, the left postcentral ROI demonstrated increased connectivity with the thalamus bilaterally in SCI patients. Our results suggest that cortical activation patterns in the sensorimotor network undergo dynamic reorganization following SCI. The presence of these changes in chronic spinal cord injury patients is suggestive of the inherent neural plasticity within the central nervous system