The use of clinical, behavioral, and social determinants of health to improve identification of patients in need of advanced care for depression

Indiana University-Purdue University Indianapolis (IUPUI)Depression is the most commonly occurring mental illness the world over. It poses a significant health and economic burden across the individual and community. Not all occurrences of depression require the same level of treatment. However, identifying patients in need of advanced care has been challenging and presents a significant bottleneck in providing care. We developed a knowledge-driven depression taxonomy comprised of features representing clinical, behavioral, and social determinants of health (SDH) that inform the onset, progression, and outcome of depression. We leveraged the depression taxonomy to build decision models that predicted need for referrals across: (a) the overall patient population and (b) various high-risk populations. Decision models were built using longitudinal, clinical, and behavioral data extracted from a population of 84,317 patients seeking care at Eskenazi Health of Indianapolis, Indiana. Each decision model yielded significantly high predictive performance. However, models predicting need of treatment across high-risk populations (ROC’s of 86.31% to 94.42%) outperformed models representing the overall patient population (ROC of 78.87%). Next, we assessed the value of adding SDH into each model. For each patient population under study, we built additional decision models that incorporated a wide range of patient and aggregate-level SDH and compared their performance against the original models. Models that incorporated SDH yielded high predictive performance. However, use of SDH did not yield statistically significant performance improvements. Our efforts present significant potential to identify patients in need of advanced care using a limited number of clinical and behavioral features. However, we found no benefit to incorporating additional SDH into these models. Our methods can also be applied across other datasets in response to a wide variety of healthcare challenges

The Bionic Radiologist: avoiding blurry pictures and providing greater insights

Radiology images and reports have long been digitalized. However, the potential of the more than 3.6 billion radiology examinations performed annually worldwide has largely gone unused in the effort to digitally transform health care. The Bionic Radiologist is a concept that combines humanity and digitalization for better health care integration of radiology. At a practical level, this concept will achieve critical goals: (1) testing decisions being made scientifically on the basis of disease probabilities and patient preferences; (2) image analysis done consistently at any time and at any site; and (3) treatment suggestions that are closely linked to imaging results and are seamlessly integrated with other information. The Bionic Radiologist will thus help avoiding missed care opportunities, will provide continuous learning in the work process, and will also allow more time for radiologists’ primary roles: interacting with patients and referring physicians. To achieve that potential, one has to cope with many implementation barriers at both the individual and institutional levels. These include: reluctance to delegate decision making, a possible decrease in image interpretation knowledge and the perception that patient safety and trust are at stake. To facilitate implementation of the Bionic Radiologist the following will be helpful: uncertainty quantifications for suggestions, shared decision making, changes in organizational culture and leadership style, maintained expertise through continuous learning systems for training, and role development of the involved experts. With the support of the Bionic Radiologist, disparities are reduced and the delivery of care is provided in a humane and personalized fashion

The Role of Social Workers in Addressing Patients' Unmet Social Needs in the Primary Care Setting

Indiana University-Purdue University Indianapolis (IUPUI)Unmet social needs pose significant risk to both patients and healthcare organizations by increasing morbidity, mortality, utilization, and costs. Health care delivery organizations are increasingly employing social workers to address social needs, given the growing number of policies mandating them to identify and address their patients’ social needs. However, social workers largely document their activities using unstructured or semi-structured textual descriptions, which may not provide information that is useful for modeling, decision-making, and evaluation. Therefore, without the ability to convert these social work documentations into usable information, the utility of these textual descriptions may be limited. While manual reviews are costly, time-consuming, and require technical skills, text mining algorithms such as natural language processing (NLP) and machine learning (ML) offer cheap and scalable solutions to extracting meaningful information from large text data. Moreover, the ability to extract information on social needs and social work interventions from free-text data within electronic health records (EHR) offers the opportunity to comprehensively evaluate the outcomes specific social work interventions. However, the use of text mining tools to convert these text data into usable information has not been well explored. Furthermore, only few studies sought to comprehensively investigate the outcomes of specific social work interventions in a safety-net population. To investigate the role of social workers in addressing patients’ social needs, this dissertation: 1) utilizes NLP, to extract and categorize the social needs that lead to referral to social workers, and market basket analysis (MBA), to investigate the co-occurrence of these social needs; 2) applies NLP, ML, and deep learning techniques to extract and categorize the interventions instituted by social workers to address patients’ social needs; and 3) measures the effects of receiving a specific social work intervention type on healthcare utilization outcomes

Simulation and Modeling for Improving Access to Care for Underserved Populations

Indiana University-Purdue University Indianapolis (IUPUI)This research, through partnership with seven Community Health Centers (CHCs) in Indiana, constructed effective outpatient appointment scheduling systems by determining care needs of CHC patients, designing an infrastructure for meaningful use of patient health records and clinic operational data, and developing prediction and simulation models for improving access to care for underserved populations. The aims of this study are 1) redesigning appointment scheduling templates based on patient characteristics, diagnoses, and clinic capacities in underserved populations; 2) utilizing predictive modeling to improve understanding the complexity of appointment adherence in underserved populations; and 3) developing simulation models with complex data to guide operational decision-making in community health centers. This research addresses its aims by applying a multi-method approach from different disciplines, such as statistics, industrial engineering, computer science, health informatics, and social sciences. First, a novel method was developed to use Electronic Health Record (EHR) data for better understanding appointment needs of the target populations based on their characteristics and reasons for seeking health, which helped simplify, improve, and redesign current appointment type and duration models. Second, comprehensive and informative predictive models were developed to better understand appointment non-adherence in community health centers. Logistic Regression, Naïve Bayes Classifier, and Artificial Neural Network found factors contributing to patient no-show. Predictors of appointment non-adherence might be used by outpatient clinics to design interventions reducing overall clinic no-show rates. Third, a simulation model was developed to assess and simulate scheduling systems in CHCs, and necessary steps to extract information for simulation modeling of scheduling systems in CHCs are described. Agent-Based Models were built in AnyLogic to test different scenarios of scheduling methods, and to identify how these scenarios could impact clinic access performance. This research potentially improves well-being of and care quality and timeliness for uninsured, underinsured, and underserved patients, and it helps clinics predict appointment no-shows and ensures scheduling systems are capable of properly meeting the populations’ care needs.2021-12-2

Data Science Methods for Nursing-Relevant Patient Outcomes and Clinical Processes The 2019 Literature Year in Review

Data science continues to be recognized and used within healthcare due to the increased availability of large data sets and advanced analytics. It can be challenging for nurse leaders to remain apprised of this rapidly changing landscape. In this article, we describe our findings from a scoping literature review of papers published in 2019 that use data science to explore, explain, and/or predict 15 phenomena of interest to nurses. Fourteen of the 15 phenomena were associated with at least one paper published in 2019. We identified the use of many contemporary data science methods (eg, natural language processing, neural networks) for many of the outcomes. We found many studies exploring Readmissions and Pressure Injuries. The topics of Artificial Intelligence/Machine Learning Acceptance, Burnout, Patient Safety, and Unit Culture were poorly represented. We hope that the studies described in this article help readers: (1) understand the breadth and depth of data science\u27s ability to improve clinical processes and patient outcomes that are relevant to nurses and (2) identify gaps in the literature that are in need of exploratio

Social and Behavioral Domains in Acute Care Electronic Health Records: Barriers, Facilitators, Relevance, and Value.

Ph.D. Thesis. University of Hawaiʻi at Mānoa 2018

An Examination Of Clinical Decision Support For Discharge Planning: Systematic Review, Simulation, And Natural Language Processing To Elucidate Referral Decision Making

Statement of the Problem: As healthcare data becomes increasingly prolific and older adult patient needs become more complex, there is opportunity for evidence-based technology such as clinical decision support systems (CDSS) to improve decision making at the point of care. Although CDSS for discharge planning is available, few published tools have been translated to new settings. Existing studies have not explored discordance between recommended and actual discharge disposition. Understanding the reasons why patients do not receive optimal post-acute care referrals is critical to improving the discharge planning process for older adults and their families. Methods: Three-paper dissertation examining CDSS. Paper 1 is a systematic review of studies with prediction models for post-acute care (PAC) destination. Paper 2 is a retrospective simulation of a discharge planning CDSS on electronic health record (EHR) data from two hospitals to examine differences in patient characteristics and 30-day readmission rates based on a CDSS recommendation among patients discharged home to self-care. Paper 3 is a natural language processing (NLP) study including retrospective analysis of narrative clinical notes to identify barriers to PAC among hospitalized older adults and create an NLP system to identify sentences containing negative patient preferences. Results: Most prediction models in the literature were developed for specific surgical populations using retrospective structured EHR data. Most models demonstrated high risk of bias and few published follow-up studies. In the simulation study, surgical patients identified by the CDSS as needing PAC but discharged home to self-care experienced adjusted 51.8% higher odds of 30-day readmission compared to those not identified. In the NLP study, the top three barriers were patient has a caregiver, negative preferences, and case management clinical reasoning. Most patients experienced multiple barriers. The negative preferences NLP system achieved an F1-Score of 0.916 using a deep learning model after internal validation. Conclusions: Future prediction modeling studies should follow TRIPOD guidelines to ensure rigorous reporting. Findings from the simulation and NLP studies suggest transportability of the CDSS to large urban academic health systems, especially among surgical patients. Incorporating natural language processing variables into CDSS tools may aid the identification of barriers to PAC

The Next Frontier in Communication and the ECLIPPSE Study: Bridging the Linguistic Divide in Secure Messaging

abstract: Health systems are heavily promoting patient portals. However, limited health literacy (HL) can restrict online communication via secure messaging (SM) because patients’ literacy skills must be sufficient to convey and comprehend content while clinicians must encourage and elicit communication from patients and match patients’ literacy level. This paper describes the Employing Computational Linguistics to Improve Patient-Provider Secure Email (ECLIPPSE) study, an interdisciplinary effort bringing together scientists in communication, computational linguistics, and health services to employ computational linguistic methods to (1) create a novel Linguistic Complexity Profile (LCP) to characterize communications of patients and clinicians and demonstrate its validity and (2) examine whether providers accommodate communication needs of patients with limited HL by tailoring their SM responses. We will study >5 million SMs generated by >150,000 ethnically diverse type 2 diabetes patients and >9000 clinicians from two settings: an integrated delivery system and a public (safety net) system. Finally, we will then create an LCP-based automated aid that delivers real-time feedback to clinicians to reduce the linguistic complexity of their SMs. This research will support health systems’ journeys to become health literate healthcare organizations and reduce HL-related disparities in diabetes care.The article is published at https://www.hindawi.com/journals/jdr/2017/1348242

Ethical Issues in Text Mining for Mental Health

A recent systematic review of Machine Learning (ML) approaches to health data, containing over 100 studies, found that the most investigated problem was mental health (Yin et al., 2019). Relatedly, recent estimates suggest that between 165,000 and 325,000 health and wellness apps are now commercially available, with over 10,000 of those designed specifically for mental health (Carlo et al., 2019). In light of these trends, the present chapter has three aims: (1) provide an informative overview of some of the recent work taking place at the intersection of text mining and mental health so that we can (2) highlight and analyze several pressing ethical issues that are arising in this rapidly growing field and (3) suggest productive directions for how these issues might be better addressed within future interdisciplinary work to ensure the responsible development of text mining approaches in psychology generally, and in mental health fields, specifically. In Section 1, we review some of the recent literature on text-mining and mental health in the contexts of traditional experimental settings, social media, and research involving electronic health records. Then, in Section 2, we introduce and discuss ethical concerns that arise before, during, and after research is conducted. Finally, in Section 3, we offer several suggestions about how ethical oversight of text-mining research might be improved to be more responsive to the concerns mapped out in Section 2

Clinical text data in machine learning: Systematic review

Background: Clinical narratives represent the main form of communication within healthcare providing a personalized account of patient history and assessments, offering rich information for clinical decision making. Natural language processing (NLP) has repeatedly demonstrated its feasibility to unlock evidence buried in clinical narratives. Machine learning can facilitate rapid development of NLP tools by leveraging large amounts of text data. Objective: The main aim of this study is to provide systematic evidence on the properties of text data used to train machine learning approaches to clinical NLP. We also investigate the types of NLP tasks that have been supported by machine learning and how they can be applied in clinical practice. Methods: Our methodology was based on the guidelines for performing systematic reviews. In August 2018, we used PubMed, a multi-faceted interface, to perform a literature search against MEDLINE. We identified a total of 110 relevant studies and extracted information about the text data used to support machine learning, the NLP tasks supported and their clinical applications. The data properties considered included their size, provenance, collection methods, annotation and any relevant statistics. Results: The vast majority of datasets used to train machine learning models included only hundreds or thousands of documents. Only 10 studies used tens of thousands of documents with a handful of studies utilizing more. Relatively small datasets were utilized for training even when much larger datasets were available. The main reason for such poor data utilization is the annotation bottleneck faced by supervised machine learning algorithms. Active learning was explored to iteratively sample a subset of data for manual annotation as a strategy for minimizing the annotation effort while maximizing predictive performance of the model. Supervised learning was successfully used where clinical codes integrated with free text notes into electronic health records were utilized as class labels. Similarly, distant supervision was used to utilize an existing knowledge base to automatically annotate raw text. Where manual annotation was unavoidable, crowdsourcing was explored, but it remains unsuitable due to sensitive nature of data considered. Beside the small volume, training data were typically sourced from a small number of institutions, thus offering no hard evidence about the transferability of machine learning models. The vast majority of studies focused on the task of text classification. Most commonly, the classification results were used to support phenotyping, prognosis, care improvement, resource management and surveillance. Conclusions: We identified the data annotation bottleneck as one of the key obstacles to machine learning approaches in clinical NLP. Active learning and distant supervision were explored as a way of saving the annotation efforts. Future research in this field would benefit from alternatives such as data augmentation and transfer learning, or unsupervised learning, which does not require data annotation