Laboratory observations of permeability enhancement by fluid pressure oscillation of in situ fractured rock

We report on laboratory experiments designed to investigate the influence of pore pressure oscillations on the effective permeability of fractured rock. Berea sandstone samples were fractured in situ under triaxial stresses of tens of megapascals, and deionized water was forced through the incipient fracture under conditions of steady and oscillating pore pressure. We find that short-term pore pressure oscillations induce long-term transient increases in effective permeability of the fractured samples. The magnitude of the effective permeability enhancements scales with the amplitude of pore pressure oscillations, and changes persist well after the stress perturbation. The maximum value of effective permeability enhancement is 5 × 10^(−16) m^2 with a background permeability of 1 × 10^(−15) m^2; that is, the maximum enhanced permeability is 1.5 × 10^(−15) m^2. We evaluate poroelastic effects and show that hydraulic storage release does not explain our observations. Effective permeability recovery following dynamic oscillations occurs as the inverse square root of time. The recovery indicates that a reversible mechanism, such as clogging/unclogging of fractures, as opposed to an irreversible one, like microfracturing, is responsible for the transient effective permeability increase. Our work suggests the feasibility of dynamically controlling the effective permeability of fractured systems. The result has consequences for models of earthquake triggering and permeability enhancement in fault zones due to dynamic shaking from near and distant earthquakes

Transmission Studies of Left-handed Materials

Left-handed materials are studied numerically using an improved version of the transfer-matrix method. The transmission, reflection, the phase of the reflection and the absorption are calculated and compared with experiments for both single split-ring resonators (SRR) with negative permeability and left-handed materials (LHMs) which have both the permittivity and permeability negative. Our results suggest ways of positively identifying materials that have both permittivity and permeability negative, from materials that have either permeability or permittivity negative

Permeability evolution during progressive development of deformation bands in porous sandstones

[1] Triaxial deformation experiments were carried out on large (0.1 m) diameter cores of a porous sandstone in order to investigate the evolution of bulk sample permeability as a function of axial strain and effective confining pressure. The log permeability of each sample evolved via three stages: (1) a linear decrease prior to sample failure associated with poroelastic compaction, (2) a transient increase associated with dynamic stress drop, and (3) a systematic quasi-static decrease associated with progressive formation of new deformation bands with increasing inelastic axial strain. A quantitative model for permeability evolution with increasing inelastic axial strain is used to analyze the permeability data in the postfailure stage. The model explicitly accounts for the observed fault zone geometry, allowing the permeability of individual deformation bands to be estimated from measured bulk parameters. In a test of the model for Clashach sandstone, the parameters vary systematically with confining pressure and define a simple constitutive rule for bulk permeability of the sample as a function of inelastic axial strain and effective confining pressure. The parameters may thus be useful in predicting fault permeability and sealing potential as a function of burial depth and faul

Dietary calcium decreases but short-chain fructo-oligosaccharides increase colonic permeability in rats

An increased intestinal permeability is associated with several diseases. Nutrition can influence gut permeability. Previously, we showed that dietary Ca decreases whereas dietary short-chain fructo-oligosaccharides (scFOS) increase intestinal permeability in rats. However, it is unknown how and where in the gastrointestinal tract Ca and scFOS exert their effects. Rats were fed a Western low-Ca control diet, or a similar diet supplemented with either Ca or scFOS. Lactulose plus mannitol and Cr-EDTA were added to the diets to quantify small and total gastrointestinal permeability, respectively. Additionally, colonic tissue was mounted in Ussing chambers and exposed to faecal water of these rats. Dietary Ca immediately decreased urinary Cr-EDTA excretion by 24 % in Ca-fed rats compared with control rats. Dietary scFOS increased total Cr-EDTA permeability gradually with time, likely reflecting relatively slow gut microbiota adaptations, which finally resulted in a 30 % increase. The lactulose: mannitol ratio was 15 % higher for Ca-fed rats and 16 % lower for scFOS-fed rats compared with control rats. However, no dietary effect was present on individual urinary lactulose and mannitol excretion. The faecal waters did not influence colonic permeability in Ussing chambers. In conclusion, despite effects on the lactulose: mannitol ratio, individual lactulose values did not alter, indicating that diet did not influence small-intestinal permeability. Therefore, both nutrients affect permeability only in the colon: Ca decreases, while scFOS increase colonic permeability. As faecal water did not influence permeability in Ussing chambers, probably modulation of mucins and/or microbiota is important for the in vivo effects of dietary Ca and scFOS

Experimental measurements of the permeability of fibrous carbon at high temperature

A series of experiments was performed to obtain permeability data on FiberForm(R), a commercial carbon preform used for manufacturing thermal protection systems. A porous sample was placed in a quartz flow-tube heated by an isothermal furnace. The setup was instrumented to measure mass flow through and pressure drop across the sample. The intrinsic permeability and the Klinkenberg correction, which accounts for rarefied effects, were computed from the experimental data. The role of the gas temperature and pressure on the effective permeability is shown, and it is demonstrated that with proper data reduction, the intrinsic permeability is strictly a function of the micro-structure of the material. A function for the effective permeability of FiberForm, dependent on temperature, pressure, pore geometry, and type of gas is proposed. The intrinsic permeability was evaluated at $K_0 = 5.57 \times 10^{-11}$ m$^2$, with a Klinkenberg parameter of $8c/d_p = 2.51 \times 10^5$ m$^{-1}$ and a reference porosity of $\phi^\dagger = 0.87$

Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery

The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed complications. However, the mechanisms underlying blood-brain barrier opening are poorly understood. Here we demonstrate the role of the neurotransmitter glutamate in modulating early barrier permeability in vivo Using intravital microscopy, we show that recurrent seizures and the associated excessive glutamate release lead to increased vascular permeability in the rat cerebral cortex, through activation of NMDA receptors. NMDA receptor antagonists reduce barrier permeability in the peri-ischemic brain, whereas neuronal activation using high-intensity magnetic stimulation increases barrier permeability and facilitates drug delivery. Finally, we conducted a double-blind clinical trial in patients with malignant glial tumors, using contrast-enhanced magnetic resonance imaging to quantitatively assess blood-brain barrier permeability. We demonstrate the safety of stimulation that efficiently increased blood-brain barrier permeability in 10 of 15 patients with malignant glial tumors. We suggest a novel mechanism for the bidirectional modulation of brain vascular permeability toward increased drug delivery and prevention of delayed complications in brain disorders. SIGNIFICANCE STATEMENT: In this study, we reveal a new mechanism that governs blood-brain barrier (BBB) function in the rat cerebral cortex, and, by using the discovered mechanism, we demonstrate bidirectional control over brain endothelial permeability. Obviously, the clinical potential of manipulating BBB permeability for neuroprotection and drug delivery is immense, as we show in preclinical and proof-of-concept clinical studies. This study addresses an unmet need to induce transient BBB opening for drug delivery in patients with malignant brain tumors and effectively facilitate BBB closure in neurological disorders

Structural heterogeneity and permeability in faulted eolian sandstone: Implications for subsurface modeling of faults

We determined the structure and permeability variations of a 4 km-long normal fault by integrating surface mapping with data from five boreholes drilled through the fault (borehole to tens of meters scale). The Big Hole fault outcrops in the Jurassic Navajo Sandstone, central Utah. A total of 363.2 m of oriented drill core was recovered at two sites where fault displacement is 8 and 3-5 m. The main fault core is a narrow zone of intensely comminuted grains that is a maximum of 30 cm thick and is composed of low-porosity amalgamated deformation bands that have slip surfaces on one or both sides. Probe permeameter measurements showed a permeability decline from greater than 2000 to less than 0.1 md as the fault is approached. Whole-core analyses showed that fault core permeability is less than I md and individual deformation band permeability is about 1 md. Using these data, we calculated the bulk permeability of the fault zone. Calculated transverse permeability over length scales of 5-10 m is 30-40 md, approximately 1-4% the value of the host rock. An inverse power mean calculation (representing a fault array with complex geometry) yielded total fault-zone permeabilities of 7-57 md. The bulk fault-zone permeability is most sensitive to variations in fault core thickness, which exhibits the greatest variability of the fault components

Flow of pH-responsive microcapsules in porous media

This article investigates the use micro-capsules, containing a gelling agent hydroxypropyl cellulose (HPC), to alter flow paths in porous media. The aim is to preferentially block-off high permeability regions, thereby diverting the flow into adjacent un-swept low permeability regions. Micro-capsules with 2 – 7 µm in diameter, were made by polymer precipitation through solvent evaporation usingpoly(4-vinyl pyridine) (PVP) as the shell material. A customized flow tank was constructed to facilitate porous media flow and both single and dual permeability experiments were conducted. Even without gelling agent, the micro-capsules gradually blocked the pore throats of the glass beads network. Following acidification a drop in permeability was observed. This was because swelling of the PVP shell constricted the pore throats. The permeability drop was observed to be more significant for low permeability regions. Flowing micro-capsules through the tank with two permeability regions in parallel, allowed the high permeability region to be selectively blocked