The oral microbiome and adverse pregnancy outcomes.

Significant evidence supports an association between periodontal pathogenic bacteria and preterm birth and preeclampsia. The virulence properties assigned to specific oral pathogenic bacteria, for example, Fusobacterium nucleatum, Porphyromonas gingivalis, Filifactor alocis, Campylobacter rectus, and others, render them as potential collaborators in adverse outcomes of pregnancy. Several pathways have been suggested for this association: 1) hematogenous spread (bacteremia) of periodontal pathogens; 2) hematogenous spread of multiple mediators of inflammation that are generated by the host and/or fetal immune response to pathogenic bacteria; and 3) the possibility of oral microbial pathogen transmission, with subsequent colonization, in the vaginal microbiome resulting from sexual practices. As periodontal disease is, for the most part, preventable, the medical and dental public health communities can address intervention strategies to control oral inflammatory disease, lessen the systemic inflammatory burden, and ultimately reduce the potential for adverse pregnancy outcomes. This article reviews the oral, vaginal, and placental microbiomes, considers their potential impact on preterm labor, and the future research needed to confirm or refute this relationship

Identifikasi bakteri patogen pada kuda laut (hippocampus kuda) di balai budidaya laut, Lampung

Abstract Sea horse (Hippocampus kuda) is one of the ornamental marine organisms and raw material of traditional medicine. Since 1993, Seafarming Development Centre, Lampung has pioneered a research and culture of sea horse in Indonesia. The serious problem in the culture of sea horse is pathogenic bacteria caused death of juveniles and broodstocks. The objective of this study was to identify pathogenic bacteria isolated from sea horse in Seafarming Development Centre. Koch Postulate test was carried out, and then the pathogenic bacteria were identifed by morphological and biochemical tests. Results showed that from a total of 6 bacterial strains isolated from diseased sea horse, 3 strains were pathogenic bacteria to sea horse. These 3 pathogenic bacteria caused identical disease signs with the initial disease signs when the bacteria were isolated. Morphological and biochemical tests suggested that the pathogenic bacteria could be identified to be Vibrio fluviatis, V. algTholyticus and V. hoilisae. Key words pathogenic bacteria, sea horse, Vibrio fluvialis, V. alginolyticus, V. hollisa

The Landscape of Realized Homologous Recombination in Pathogenic Bacteria

Recombination enhances the adaptive potential of organisms by allowing genetic variants to be tested on multiple genomic backgrounds. Its distribution in the genome can provide insight into the evolutionary forces that underlie traits, such as the emergence of pathogenicity. Here, we examined landscapes of realized homologous recombination of 500 genomes from ten bacterial species and found all species have “hot” regions with elevated rates relative to the genome average. We examined the size, gene content, and chromosomal features associated with these regions and the correlations between closely related species. The recombination landscape is variable and evolves rapidly. For example in Salmonella, only short regions of around 1 kb in length are hot whereas in the closely related species Escherichia coli, some hot regions exceed 100 kb, spanning many genes. Only Streptococcus pyogenes shows evidence for the positive correlation between GC content and recombination that has been reported for several eukaryotes. Genes with function related to the cell surface/membrane are often found in recombination hot regions but E. coli is the only species where genes annotated as “virulence associated” are consistently hotter. There is also evidence that some genes with “housekeeping” functions tend to be overrepresented in cold regions. For example, ribosomal proteins showed low recombination in all of the species. Among specific genes, transferrin-binding proteins are recombination hot in all three of the species in which they were found, and are subject to interspecies recombination

Pathogenic bacteria in man

Thesis (M.A.)--Boston University This item was digitized by the Internet Archive