Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates

The study of cerebral anatomy in developing neonates is of great importance for the understanding of brain development during the early period of life. This dissertation therefore focuses on three challenges in the modelling of cerebral anatomy in neonates during brain development. The methods that have been developed all use Magnetic Resonance Images (MRI) as source data. To facilitate study of vascular development in the neonatal period, a set of image analysis algorithms are developed to automatically extract and model cerebral vessel trees. The whole process consists of cerebral vessel tracking from automatically placed seed points, vessel tree generation, and vasculature registration and matching. These algorithms have been tested on clinical Time-of- Flight (TOF) MR angiographic datasets. To facilitate study of the neonatal cortex a complete cerebral cortex segmentation and reconstruction pipeline has been developed. Segmentation of the neonatal cortex is not effectively done by existing algorithms designed for the adult brain because the contrast between grey and white matter is reversed. This causes pixels containing tissue mixtures to be incorrectly labelled by conventional methods. The neonatal cortical segmentation method that has been developed is based on a novel expectation-maximization (EM) method with explicit correction for mislabelled partial volume voxels. Based on the resulting cortical segmentation, an implicit surface evolution technique is adopted for the reconstruction of the cortex in neonates. The performance of the method is investigated by performing a detailed landmark study. To facilitate study of cortical development, a cortical surface registration algorithm for aligning the cortical surface is developed. The method first inflates extracted cortical surfaces and then performs a non-rigid surface registration using free-form deformations (FFDs) to remove residual alignment. Validation experiments using data labelled by an expert observer demonstrate that the method can capture local changes and follow the growth of specific sulcus

Consistent joint photometric and geometric image registration

In this paper, we derive a novel robust image alignment technique that performs joint geometric and photometric registration in the total least square sense. The main idea is to use the total least square metrics instead of the ordinary least square metrics, which is commonly used in the literature. While the OLS model indicates that the target image may contain noise and the reference image should be noise-free, this puts a severe limitation on practical registration problems. By introducing the TLS model, which allows perturbations in both images, we can obtain mutually consistent parameters. Experimental results show that our method is indeed much more consistent and accurate in presence of noise compared to existing registration algorithms

A Hybrid Parameterization Technique for Speaker Identification

Classical parameterization techniques for Speaker Identification use the codification of the power spectral density of raw speech, not discriminating between articulatory features produced by vocal tract dynamics (acoustic-phonetics) from glottal source biometry. Through the present paper a study is conducted to separate voicing fragments of speech into vocal and glottal components, dominated respectively by the vocal tract transfer function estimated adaptively to track the acoustic-phonetic sequence of the message, and by the glottal characteristics of the speaker and the phonation gesture. The separation methodology is based in Joint Process Estimation under the un-correlation hypothesis between vocal and glottal spectral distributions. Its application on voiced speech is presented in the time and frequency domains. The parameterization methodology is also described. Speaker Identification experiments conducted on 245 speakers are shown comparing different parameterization strategies. The results confirm the better performance of decoupled parameterization compared against approaches based on plain speech parameterization

Ultrasound IMT measurement on a multi-ethnic and multi-institutional database: Our review and experience using four fully automated and one semi-automated methods

Automated and high performance carotid intima-media thickness (IMT) measurement is gaining increasing importance in clinical practice to assess the cardiovascular risk of patients. In this paper, we compare four fully automated IMT measurement techniques (CALEX, CAMES, CARES and CAUDLES) and one semi-automated technique (FOAM). We present our experience using these algorithms, whose lumen-intima and media-adventitia border estimation use different methods that can be: (a) edge-based; (b) training-based; (c) feature-based; or (d) directional Edge-Flow based. Our database (DB) consisted of 665 images that represented a multi-ethnic group and was acquired using four OEM scanners. The performance evaluation protocol adopted error measures, reproducibility measures, and Figure of Merit (FoM). FOAM showed the best performance, with an IMT bias equal to 0.025 ± 0.225 mm, and a FoM equal to 96.6%. Among the four automated methods, CARES showed the best results with a bias of 0.032 ± 0.279 mm, and a FoM to 95.6%, which was statistically comparable to that of FOAM performance in terms of accuracy and reproducibility. This is the first time that completely automated and user-driven techniques have been compared on a multi-ethnic dataset, acquired using multiple original equipment manufacturer (OEM) machines with different gain settings, representing normal and pathologic case

Automatic detection of arcs and arclets formed by gravitational lensing

We present an algorithm developed particularly to detect gravitationally lensed arcs in clusters of galaxies. This algorithm is suited for automated surveys as well as individual arc detections. New methods are used for image smoothing and source detection. The smoothing is performed by so-called anisotropic diffusion, which maintains the shape of the arcs and does not disperse them. The algorithm is much more efficient in detecting arcs than other source finding algorithms and the detection by eye.Comment: A&A in press, 12 pages, 16 figure

Age Sensitivity of Face Recognition Algorithms

This paper investigates the performance degradation of facial recognition systems due to the influence of age. A comparative analysis of verification performance is conducted for four subspace projection techniques combined with four different distance metrics. The experimental results based on a subset of the MORPH-II database show that the choice of subspace projection technique and associated distance metric can have a significant impact on the performance of the face recognition system for particular age groups