3D/2D Registration of Mapping Catheter Images for Arrhythmia Interventional Assistance

Radiofrequency (RF) catheter ablation has transformed treatment for tachyarrhythmias and has become first-line therapy for some tachycardias. The precise localization of the arrhythmogenic site and the positioning of the RF catheter over that site are problematic: they can impair the efficiency of the procedure and are time consuming (several hours). Electroanatomic mapping technologies are available that enable the display of the cardiac chambers and the relative position of ablation lesions. However, these are expensive and use custom-made catheters. The proposed methodology makes use of standard catheters and inexpensive technology in order to create a 3D volume of the heart chamber affected by the arrhythmia. Further, we propose a novel method that uses a priori 3D information of the mapping catheter in order to estimate the 3D locations of multiple electrodes across single view C-arm images. The monoplane algorithm is tested for feasibility on computer simulations and initial canine data.Comment: International Journal of Computer Science Issues, IJCSI, Volume 4, Issue 2, pp10-19, September 200

3D reconstruction of coronary arteries from angiographic sequences for interventional assistance

Introduction -- Review of literature -- Research hypothesis and objectives -- Methodology -- Results and discussion -- Conclusion and future perspectives

Photoacoustics for Cardiovascular Applications

In the thesis entitled Photoacoustic imaging for Cardiovascular Applications, two cardiovascular diseases were tackled, namely atrial fibrillation and coronary atherosclerosis. An imaging algorithm was also devised to enhance imaging target super-localization. Photoacoustic imaging is an imaging modality which provides molecular information, based on optical absorption and subsequent thermoelastic expansion resulting in detectable pressure waves with common ultrasonic detectors. Capability of imaging tissue molecular changes was shown relevant to enable real-time monitoring of lesion formation in catheter-based ablation for atrial fibrillation as well as to assess lipid content of atherosclerotic plaques in an animal model in vivo. This thesis describes the development and design of the photoacoustic imaging system from instrumentation to realization in clinically translatable setups