A comprehensive survey on cultural algorithms

Peer reviewedPostprin

Evolutionary Computation

This book presents several recent advances on Evolutionary Computation, specially evolution-based optimization methods and hybrid algorithms for several applications, from optimization and learning to pattern recognition and bioinformatics. This book also presents new algorithms based on several analogies and metafores, where one of them is based on philosophy, specifically on the philosophy of praxis and dialectics. In this book it is also presented interesting applications on bioinformatics, specially the use of particle swarms to discover gene expression patterns in DNA microarrays. Therefore, this book features representative work on the field of evolutionary computation and applied sciences. The intended audience is graduate, undergraduate, researchers, and anyone who wishes to become familiar with the latest research work on this field

Aerospace medicine and biology: A continuing bibliography with indexes (supplement 349)

This bibliography lists 149 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during April, 1991. Subject coverage includes: aerospace medicine and psychology, life support systems and controlled environments, safety equipment, exobiology and extraterrestrial life, and flight crew behavior and performance

Enhanced structure determination from powder diffraction data via algorithm optimisation and the use of conformational information

The performance of DASH has been evaluated against powder X-ray diffraction data collected from 101 molecular crystal structures, representing the most comprehensive testing of a "structure determination from powder diffraction data" (SDPD) program carried out to date. These 101 structures cover a broad range of molecular complexities, from very simple (6 degrees of freedom) to very challenging (49 degrees of freedom). 95 of the crystal structures could be solved with the current version of DASH, going some way to explaining why the parameterisation of its simulated annealing (SA) algorithm has not been altered since the launch of the program in 1999. This thesis explores optimisation of key DASH SA parameters using the program irace. The irace runs, comprising 255,000 individual DASH runs and requiring approximately 1300 CPU days of compute time, produced six sets of SA parameters which differed greatly from the DASH default parameters and which markedly improved the performance of DASH. Further evaluation of these six sets against all 101 compounds (a further 2874 of days of CPU time), allowed selection of one best-performing set, which delivered an order of magnitude improvement in the success rate with which crystal structures were solved. The adoption of these parameter values as the defaults in future releases of DASH is strongly recommended and is expected to broaden the range of molecular complexities to which the program can be applied. Three distinct approaches to further improving DASH performance, based on introducing prior conformational knowledge derived from the Cambridge Structural Database (CSD), have also been assesed. The findings show that inclusion of conformational knowledge brings significant additional gains in SDPD performance, and that existing implementations of these approaches in the DASH / CSD System are close to being ready for routine use

The doctoral research abstracts. Vol:6 2014 / Institute of Graduate Studies, UiTM

Congratulations to Institute of Graduate Studies on the continuous efforts to publish the 6th issue of the Doctoral Research Abstracts which ranged from the discipline of science and technology, business and administration to social science and humanities. This issue captures the novelty of research from 52 PhD doctorates receiving their scrolls in the UiTM’s 81st Convocation. This convocation is very significant especially for UiTM since we are celebrating the success of 52 PhD graduands – the highest number ever conferred at any one time. To the 52 doctorates, I would like it to be known that you have most certainly done UiTM proud by journeying through the scholastic path with its endless challenges and impediments, and by persevering right till the very end. This convocation should not be regarded as the end of your highest scholarly achievement and contribution to the body of knowledge but rather as the beginning of embarking into more innovative research from knowledge gained during this academic journey, for the community and country. As alumni of UiTM, we hold you dear to our hearts. The relationship that was once between a student and supervisor has now matured into comrades, forging and exploring together beyond the frontier of knowledge. We wish you all the best in your endeavour and may I offer my congratulations to all the graduands. ‘UiTM sentiasa dihati ku’ Tan Sri Dato’ Sri Prof Ir Dr Sahol Hamid Abu Bakar , FASc, PEng Vice Chancellor Universiti Teknologi MAR

Eleventh European Powder Diffraction Conference. Warsaw, September 19-22, 2008

Zeitschrift für Kristallographie. Supplement Volume 30 presents the complete Proceedings of all contributions to the XI European Powder Diffraction Conference in Warsaw 2008: Method Development and Application,Instrumental, Software Development, Materials. Supplement Series of Zeitschrift für Kristallographie publishes Proceedings and Abstracts of international conferences on the interdisciplinary field of crystallography

Breast Cancer Progression and Phytoestrogen Interactions with Estrogen Receptors

Breast cancer is one of the most common diseases affecting women and approximately 1.3 million females are diagnosed each year with this disease worldwide. Breast cancer is a multi-factorial disease and it is difficult to predict or control the physiopathology, to date one of the major risk factors alongside the patient’s genetic background is life time exposure to estrogen. Understanding the estrogen receptor (ER) has been a milestone in elucidating breast cancer biology, leading to advances in disease management. Alongside this, evidence from epidemiological studies suggests that dietary consumption of phytoestrogens may modulate disease progression. This study hypothesises that the interaction between some phytoestrogens (present in the pre-diagnosis diet or in the new diet adopted by breast cancer patients) and specific ER isoforms displayed in breast tumours influences the action of synthetic and endogenous estrogen in breast cancer cells. This study aimed to understand the interaction between estrogen, hormone drugs and phytoestrogens on the ER. In silico modelling of the ER focused on the wild type isoforms ERα and ERβ and different ligands (SWISS MODEL and docked through AutoDock Vina). Subsequently, isoforms of ERα and ERβ and different ligands (E1, E2, E3, PE, Tamoxifen, ICI 182,780) were modelled and tested by docking against the same set of ligands (E1, E2, E3, PE, Tamoxifen, ICI 182,780). The system described here highlighted the main amino acid residues of the LBD of ERα and ERβ along with ligand interactions for both agonists and antagonists, described in previous X-ray crystallography experiments. All of the phytoestrogens studied using AutoDock Vina interacted with the hormone binding site of both ERα and ERβ, due the phenolic ring of the studied structure which favoured the interaction with the hydrophobic environment of LBD amino acids. All of the dietary phytoestrogens showed lower binding affinity (<9.1 Kcal/mol) compared with estradiol (-10.6 Kcal/mol) in all the isoforms and isotypes studied, suggesting that phytoestrogens should not displace estradiol from the LBD, however it remains unclear if PE can act as an agonist compound in the ER pathways. Also, some phytoestrogens appeared to have greater affinity to the ERα and ERβ than Tamoxifen (antagonist models), but it is uncertain as to whether the resulting structure will interfere with subsequent interactions. Further laboratory experiments will be necessary to understand the impact of the PE in the ERs structure and the respective role in the ER pathway. The data from this computer modelling approach has provided an insight into the interactions between endogenous estrogens, drugs, phytoestrogens and ER. The in silico studies generated a system that recapitulated data obtained by other research groups (experimentally) and will be of value as a screening tool for further studies of new drugs and exogenous estrogens and their potential role in ER-induced breast cancer pathophysiology

Complexity, Emergent Systems and Complex Biological Systems:\ud Complex Systems Theory and Biodynamics. [Edited book by I.C. Baianu, with listed contributors (2011)]

An overview is presented of System dynamics, the study of the behaviour of complex systems, Dynamical system in mathematics Dynamic programming in computer science and control theory, Complex systems biology, Neurodynamics and Psychodynamics.\u

Functional and structural studies of an Enterococcal Serine/Threonine kinase and its contribution to antibiotic resistance mechanisms

The emergence of vancomycin-resistant enterococci (VRE) since the 1980s has turned this Gram-positive bacterium into a serious and growing clinical challenge. Enterococci have acquired resistance to a number of different antibiotics and are intrinsically resistant to cephalosporin b-lactam drugs. As a result, they are now placed in the World Health Organisation list of priority pathogens for which new antibiotics are urgently needed. An important risk factor for the emergence of VRE is treatment with cephalosporins, suggesting a connection between the origins of resistance between these two different types of antibiotics, the mechanistic basis for which was unknown. In this study I demonstrate that cephalosporin resistance is significantly enhanced in the well characterized E. faecalis OG1RF strain containing the Tn1549 transposon conferring the VanB type vancomycin resistance. Cephalosporin resistance is shown to be enhanced to the presence of the Tn1549 transposon and a single, chromosomally encoded Serine/Threonine (ST) kinase gene called ireK. Complementation experiments and fluorescence microscopy with a range of biophysical techniques to characterise the protein. Deletion of the gene results in cephalosporin sensitivity. Moreover, this phenotype can be chemically simulated by treatment of E. faecalis with inhibitors of cytoplasmic ST kinases such as staurosporine, demonstrating a requirement for ST kinase activity for cephalosporin resistance. This also demonstrates a therapeutic potential for targeting ST kinases in Gram-positive pathogens with small molecule inhibitors to restore cephalosporin sensitivity which may have clear translational significance. IreK was identified as a key protein involved in enhanced cephalosporin resistance and led to examination of its extracellular and intracellular domains to understand its signal transduction mechanisms and its linkage to resistance. The extracellular domain of IreK was essential for cellular location. Further biophysical experiments identified ligands for the extracellular domains include sugar motifs such as the glycan backbone of peptidoglycans and sugar containing antibiotics. This has led to a new functional model for ST kinases in enterococci