Recent Progress in Optical Sensors for Biomedical Diagnostics

In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.DFG, 428780268, Biomimetische Rezeptoren auf NanoMIP-Basis zur Virenerkennung und -entfernung mittels integrierter Ansätz

Status of the Fiber Optic Control System Integration (FOCSI) program

This report presents a discussion of the progress made in the NASA/NAVY Fiber Optic Control System Integration (FOCSI) program. This program will culminate in open-loop flight tests of passive optical sensors and associated electro-optics on an F-18 aircraft. Currently, the program is in the final stages of hardware fabrication and environmental testing of the passive optical sensors and electro-optics. This program is a foundation for future Fly-by-Light (FBL) programs. The term Fly-by-Light is used to describe the utilization of passive optical sensors and fiber optic data links for monitoring and control of aircraft in which sensor and actuation signals are transmitted optically. The benefits of this technology for advanced aircraft include the following: improved reliability and reduced certification cost due to greater immunity to EME (electromagnetic effects); reduced harness volume and weight; elimination of short circuits and sparking in wiring due to insulation deterioration; lower maintenance costs (fewer components); greater flexibility in data bus protocol and architecture; absence of ground loops; and higher operating temperatures for electrically passive optical sensors

Flexible protection architectures using distributed optical sensors

In this paper we describe recent developments in flexible protection schemes that make use of passive fibre Bragg grating (FBG) based transducers for the distributed measurement of voltage and current. The technology underpinning the passive optical approach is described in detail, and both the present development and the future potential of the approach are discussed. In co-operation with Toshiba, the integration of the technique with an existing busbar protection relay is demonstrated, illustrating the flexibility offered by protection schemes that are based on the use of small, passive, multiplexable, dielectric transducers

Optical Sensors

This book is a compilation of works presenting recent developments and practical applications in optical sensor technology. It contains 10 chapters that encompass contributions from various individuals and research groups working in the area of optical sensing. It provides the reader with a broad overview and sampling of the innovative research on optical sensors in the world

On the sensitivity of generic porous optical sensors

A porous material was considered as a platform for optical sensing. It was envisaged that the porous material was infiltrated by a fluid which contains an agent to be sensed. Changes in the optical properties of the infiltrated porous material provide the basis for detection of the agent to be sensed. Using a homogenization approach based on the Bruggeman formalism, wherein the infiltrated porous material was regarded as a homogenized composite material, the sensitivity of such a sensor was investigated. For the case of an isotropic dielectric porous material of relative permittivity $\epsilon^a$ and an isotropic dielectric fluid of relative permittivity $\epsilon^b$, it was found that the sensitivity was maximized when there was a large contrast between $\epsilon^a$ and $\epsilon^b$; the maximum sensitivity was achieved at mid-range values of porosity. Especially high sensitivities may be achieved for $\epsilon^b$ close to unity when $\epsilon^a >> 1$, for example. Furthermore, higher sensitivities may be achieved by incorporating pores which have elongated spheroidal shapes

Gravitational sensing with weak value based optical sensors

Using weak values amplification angular resolution limits, we theoretically investigate the gravitational sensing of objects. By inserting a force-sensing pendulum into a weak values interferometer, the optical response can sense accelerations to a few 10's of $\mathrm{zepto}\text{-}\mathrm{g}/\sqrt{\mathrm{Hz}}$, with optical powers of $1~\mathrm{mW}$. We convert this precision into range and mass sensitivity, focusing in detail on simple and torsion pendula. Various noise sources present are discussed, as well as the necessary cooling that should be applied to reach the desired levels of precision.Comment: 9 pages, 4 figures, Quantum Stud.: Math. Found. (2018

Study of celestial/inertial test facility Final report

Test facility and equipment for evaluation of optical sensors employed in celestial navigation and guidance system