293 research outputs found
Pathological Evidence Exploration in Deep Retinal Image Diagnosis
Though deep learning has shown successful performance in classifying the
label and severity stage of certain disease, most of them give few evidence on
how to make prediction. Here, we propose to exploit the interpretability of
deep learning application in medical diagnosis. Inspired by Koch's Postulates,
a well-known strategy in medical research to identify the property of pathogen,
we define a pathological descriptor that can be extracted from the activated
neurons of a diabetic retinopathy detector. To visualize the symptom and
feature encoded in this descriptor, we propose a GAN based method to synthesize
pathological retinal image given the descriptor and a binary vessel
segmentation. Besides, with this descriptor, we can arbitrarily manipulate the
position and quantity of lesions. As verified by a panel of 5 licensed
ophthalmologists, our synthesized images carry the symptoms that are directly
related to diabetic retinopathy diagnosis. The panel survey also shows that our
generated images is both qualitatively and quantitatively superior to existing
methods.Comment: to appear in AAAI (2019). The first two authors contributed equally
to the paper. Corresponding Author: Feng L
Multi-dataset Training for Medical Image Segmentation as a Service
Deep Learning tools are widely used for medical image segmentation. The results produced by these techniques depend to a great extent on the data sets used to train the used network. Nowadays many cloud service providers offer the required resources to train networks and deploy deep learning networks. This makes the idea of segmentation as a cloud-based service attractive. In this paper we study the possibility of training, a generalized configurable, Keras U-Net to test the feasibility of training with images acquired, with specific instruments, to perform predictions on data from other instruments. We use, as our application example, the segmentation of Optic Disc and Cup which can be applied to glaucoma detection. We use two publicly available data sets (RIM-One V3 and DRISHTI) to train either independently or combining their data.Ministerio de Economía y Competitividad TEC2016-77785-
Unsupervised Domain Adaptive Fundus Image Segmentation with Few Labeled Source Data
Deep learning-based segmentation methods have been widely employed for
automatic glaucoma diagnosis and prognosis. In practice, fundus images obtained
by different fundus cameras vary significantly in terms of illumination and
intensity. Although recent unsupervised domain adaptation (UDA) methods enhance
the models' generalization ability on the unlabeled target fundus datasets,
they always require sufficient labeled data from the source domain, bringing
auxiliary data acquisition and annotation costs. To further facilitate the data
efficiency of the cross-domain segmentation methods on the fundus images, we
explore UDA optic disc and cup segmentation problems using few labeled source
data in this work. We first design a Searching-based Multi-style Invariant
Mechanism to diversify the source data style as well as increase the data
amount. Next, a prototype consistency mechanism on the foreground objects is
proposed to facilitate the feature alignment for each kind of tissue under
different image styles. Moreover, a cross-style self-supervised learning stage
is further designed to improve the segmentation performance on the target
images. Our method has outperformed several state-of-the-art UDA segmentation
methods under the UDA fundus segmentation with few labeled source data.Comment: Accepted by The 33rd British Machine Vision Conference (BMVC) 202
TPU Cloud-Based Generalized U-Net for Eye Fundus Image Segmentation
Medical images from different clinics are acquired with different instruments and settings.
To perform segmentation on these images as a cloud-based service we need to train with multiple datasets
to increase the segmentation independency from the source. We also require an ef cient and fast segmentation
network. In this work these two problems, which are essential for many practical medical imaging
applications, are studied. As a segmentation network, U-Net has been selected. U-Net is a class of deep
neural networks which have been shown to be effective for medical image segmentation. Many different
U-Net implementations have been proposed.With the recent development of tensor processing units (TPU),
the execution times of these algorithms can be drastically reduced. This makes them attractive for cloud
services. In this paper, we study, using Google's publicly available colab environment, a generalized fully
con gurable Keras U-Net implementation which uses Google TPU processors for training and prediction.
As our application problem, we use the segmentation of Optic Disc and Cup, which can be applied to
glaucoma detection. To obtain networks with a good performance, independently of the image acquisition
source, we combine multiple publicly available datasets (RIM-One V3, DRISHTI and DRIONS). As a result
of this study, we have developed a set of functions that allow the implementation of generalized U-Nets
adapted to TPU execution and are suitable for cloud-based service implementation.Ministerio de Economía y Competitividad TEC2016-77785-
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