Effect of Vascepa (icosapent ethyl) on progression of coronary atherosclerosis in patients with elevated triglycerides (200-499 mg/dL) on statin therapy: Rationale and design of the EVAPORATE study.

Despite reducing progression and promoting regression of coronary atherosclerosis, statin therapy does not fully address residual cardiovascular (CV) risk. High-purity eicosapentaenoic acid (EPA) added to a statin has been shown to reduce CV events and induce regression of coronary atherosclerosis in imaging studies; however, data are from Japanese populations without high triglyceride (TG) levels and baseline EPA serum levels greater than those in North American populations. Icosapent ethyl is a high-purity prescription EPA ethyl ester approved at 4 g/d as an adjunct to diet to reduce TG levels in adults with TG levels >499 mg/dL. The objective of the randomized, double-blind, placebo-controlled EVAPORATE study is to evaluate the effects of icosapent ethyl 4 g/d on atherosclerotic plaque in a North American population of statin-treated patients with coronary atherosclerosis, TG levels of 200 to 499 mg/dL, and low-density lipoprotein cholesterol levels of 40 to 115 mg/dL. The primary endpoint is change in low-attenuation plaque volume measured by multidetector computed tomography angiography. Secondary endpoints include incident plaque rates; quantitative changes in different plaque types and morphology; changes in markers of inflammation, lipids, and lipoproteins; and the relationship between these changes and plaque burden and/or plaque vulnerability. Approximately 80 patients will be followed for 9 to 18 months. The clinical implications of icosapent ethyl 4 g/d treatment added to statin therapy on CV endpoints are being evaluated in the large CV outcomes study REDUCE-IT. EVAPORATE will provide important imaging-derived data that may add relevance to the clinically derived outcomes from REDUCE-IT

NASA Thesaurus Supplement: A three part cumulative supplement to the 1982 edition of the NASA Thesaurus (supplement 2)

The three part cumulative NASA Thesaurus Supplement to the 1982 edition of the NASA Thesaurus includes: part 1, hierarchical listing; part 2, access vocabulary, and part 3, deletions. The semiannual supplement gives complete hierarchies for new terms and includes new term indications for terms new to this supplement

The Impact of Monetary and Tax Policy on Income Inequality in Japan

This paper assesses the effects of the most recent monetary policy behavior of the Bank of Japan (BOJ) (in particular, zero interest rate policy and negative interest rate policy) and Japanese tax policy on income inequality in this country during the period of 2002Q1 to 2017Q3. The vector error correction model that develops in this research, shows that increase in money stock (m1) through quantitative easing (QE) and quantitative and qualitative easing (QQE) policies of the BOJ significantly increases the income inequality. On the contrary, Japanese tax policy was effective in reducing the income inequality. Variance decomposition results show after ten periods almost 87.15% of the forecast error variance of the inequality is accounted for by its own innovations and 3.76% of the forecast error variance can be explained by exogenous shocks to monetary policy shock—the money stock (M1). The short-term interest rate also accounts for the increase in inequality by 0.47%. On the other hand, the total tax and real gross domestic product contributed in reducing the inequality measure, respectively, by 6.65% and 1.96% after 10 periods

The Evolution of Income Concentration in Japan, 1886-2002: Evidence from Income Tax Statistics

This paper studies the evolution of income concentration in Japan from 1886 to 2002 by constructing long-run series of top income shares and top wage income shares, using income tax statistics. We find that (1) income concentration was extremely high throughout the pre-WWII period during which the nation underwent rapid industrialization; (2) a drastic de-concentration of income at the top took place in 1938-1945; (3) income concentration has remained low throughout the post-WWII period despite the high economic growth; and (4) top income composition in Japan has shifted dramatically from capital income to employment income over the course of the 20th century. We attribute the precipitous fall in income concentration during WWII primarily to the collapse of capital income due to wartime regulations and inflation. We argue that the change in the institutional structure under the occupational reforms made the one-time income de-concentration difficult to reverse. In contrast to the sharp increase in wage income inequality observed in the United States since 1970, the top wage income shares in Japan have remained remarkably stable over the recent decades. We show that the change in technology or tax policies alone cannot account for the comparative experience of Japan and the United States. Instead we suggest that institutional factors such as corporate governance and union structure are important determinants of wage income inequality.

Bank-firm credit network in Japan. An analysis of a bipartite network

We present an analysis of the credit market of Japan. The analysis is performed by investigating the bipartite network of banks and firms which is obtained by setting a link between a bank and a firm when a credit relationship is present in a given time window. In our investigation we focus on a community detection algorithm which is identifying communities composed by both banks and firms. We show that the clusters obtained by directly working on the bipartite network carry information about the networked nature of the Japanese credit market. Our analysis is performed for each calendar year during the time period from 1980 to 2011. Specifically, we obtain communities of banks and networks for each of the 32 investigated years, and we introduce a method to track the time evolution of these communities on a statistical basis. We then characterize communities by detecting the simultaneous over-expression of attributes of firms and banks. Specifically, we consider as attributes the economic sector and the geographical location of firms and the type of banks. In our 32 year long analysis we detect a persistence of the over-expression of attributes of clusters of banks and firms together with a slow dynamics of changes from some specific attributes to new ones. Our empirical observations show that the credit market in Japan is a networked market where the type of banks, geographical location of firms and banks and economic sector of the firm play a role in shaping the credit relationships between banks and firms.Comment: 9 pages, 4 figures, 2 Table

ESL and EFL Writing Instruction: Challenges and opportunities

Udostępnienie publikacji Wydawnictwa Uniwersytetu Łódzkiego finansowane w ramach projektu „Doskonałość naukowa kluczem do doskonałości kształcenia”. Projekt realizowany jest ze środków Europejskiego Funduszu Społecznego w ramach Programu Operacyjnego Wiedza Edukacja Rozwój; nr umowy: POWER.03.05.00-00-Z092/17-00

NASA Thesaurus Supplement: A three part cumulative supplement to the 1982 edition of the NASA Thesaurus (supplement 3)

The three part cumulative NASA Thesaurus Supplement to the 1982 edition of the NASA Thesaurus includes Part 1, Hierarchical Listing, Part 2, Access Vocabulary, and Part 3, Deletions. The semiannual supplement gives complete hierarchies for new terms and includes new term indications for entries new to this supplement

Ground-based Characterization of Hayabusa2 Mission Target Asteroid 162173 Ryugu: Constraining Mineralogical Composition in Preparation for Spacecraft Operations

Asteroids that are targets of spacecraft missions are interesting because they present us with an opportunity to validate ground-based spectral observations. One such object is near-Earth asteroid (NEA) (162173) Ryugu, which is the target of the Japanese Space Agency's (JAXA) Hayabusa2 sample return mission. We observed Ryugu using the 3-m NASA Infrared Telescope Facility (IRTF) on Mauna Kea, Hawaii, on July 13, 2016 to constrain the object's surface composition, meteorite analogs, and link to other asteroids in the main belt and NEA populations. We also modeled its photometric properties using archival data. Using the Lommel-Seeliger model we computed the predicted flux for Ryugu at a wide range of viewing geometries as well as albedo quantities such as geometric albedo, phase integral, and spherical Bond albedo. Our computed albedo quantities are consistent with results from Ishiguro et al. (2014). Our spectral analysis has found a near-perfect match between our spectrum of Ryugu and those of NEA (85275) 1994 LY and Mars-crossing asteroid (316720) 1998 BE7, suggesting that their surface regoliths have similar composition. We compared Ryugu's spectrum with that of main belt asteroid (302) Clarissa, the largest asteroid in the Clarissa asteroid family, suggested as a possible source of Ryugu by Campins et al. (2013). We found that the spectrum of Clarissa shows significant differences with our spectrum of Ryugu, but it is similar to the spectrum obtained by Moskovitz et al. (2013). The best possible meteorite analogs for our spectrum of Ryugu are two CM2 carbonaceous chondrites, Mighei and ALH83100.Comment: 23 pages, 7 figures, 4 tables, accepted in Monthly Notices of the Royal Astronomical Society Main Journa