111,676 research outputs found
Design Issues for Generalized Linear Models: A Review
Generalized linear models (GLMs) have been used quite effectively in the
modeling of a mean response under nonstandard conditions, where discrete as
well as continuous data distributions can be accommodated. The choice of design
for a GLM is a very important task in the development and building of an
adequate model. However, one major problem that handicaps the construction of a
GLM design is its dependence on the unknown parameters of the fitted model.
Several approaches have been proposed in the past 25 years to solve this
problem. These approaches, however, have provided only partial solutions that
apply in only some special cases, and the problem, in general, remains largely
unresolved. The purpose of this article is to focus attention on the
aforementioned dependence problem. We provide a survey of various existing
techniques dealing with the dependence problem. This survey includes
discussions concerning locally optimal designs, sequential designs, Bayesian
designs and the quantile dispersion graph approach for comparing designs for
GLMs.Comment: Published at http://dx.doi.org/10.1214/088342306000000105 in the
Statistical Science (http://www.imstat.org/sts/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Sequential experimental Design for Misspecified Nonlinear Models
International audienceIn design of experiments for nonlinear regression model identification, the design criterion depends on the unknown parameters to be identified. Classical strategies consist in designing sequentially the experiments by alternating the estimation and design stages. These strategies consider previous observations (collected data) only while estimating the unknown parameters during the estimation stages. This paper proposes to consider the previous observations not only during the estimation stages, but also by the criterion used during the design stages. Furthermore, the proposed criterion considers the robustness requirement: an unknown model error (misspecification) is supposed to exist and is modeled by a kernel-based representation (Gaussian process). Finally, the proposed sequential criterion is compared with a model-robust criterion which does not consider the previously collected data during the design stages, with the classical D-optimal and L-optimal criteria
Particle approximations of the score and observed information matrix for parameter estimation in state space models with linear computational cost
Poyiadjis et al. (2011) show how particle methods can be used to estimate
both the score and the observed information matrix for state space models.
These methods either suffer from a computational cost that is quadratic in the
number of particles, or produce estimates whose variance increases
quadratically with the amount of data. This paper introduces an alternative
approach for estimating these terms at a computational cost that is linear in
the number of particles. The method is derived using a combination of kernel
density estimation, to avoid the particle degeneracy that causes the
quadratically increasing variance, and Rao-Blackwellisation. Crucially, we show
the method is robust to the choice of bandwidth within the kernel density
estimation, as it has good asymptotic properties regardless of this choice. Our
estimates of the score and observed information matrix can be used within both
online and batch procedures for estimating parameters for state space models.
Empirical results show improved parameter estimates compared to existing
methods at a significantly reduced computational cost. Supplementary materials
including code are available.Comment: Accepted to Journal of Computational and Graphical Statistic
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On optimal designs for clinical trials: An updated review
Optimization of clinical trial designs can help investigators achieve higher qualityresults for the given resource constraints. The present paper gives an overviewof optimal designs for various important problems that arise in different stages ofclinical drug development, including phase I dose–toxicity studies; phase I/II studiesthat consider early efficacy and toxicity outcomes simultaneously; phase IIdose–response studies driven by multiple comparisons (MCP), modeling techniques(Mod), or their combination (MCP–Mod); phase III randomized controlled multiarmmulti-objective clinical trials to test difference among several treatment groups;and population pharmacokinetics–pharmacodynamics experiments. We find thatmodern literature is very rich with optimal design methodologies that can be utilizedby clinical researchers to improve efficiency of drug development
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