139,090 research outputs found
Training-free Measures Based on Algorithmic Probability Identify High Nucleosome Occupancy in DNA Sequences
We introduce and study a set of training-free methods of
information-theoretic and algorithmic complexity nature applied to DNA
sequences to identify their potential capabilities to determine nucleosomal
binding sites. We test our measures on well-studied genomic sequences of
different sizes drawn from different sources. The measures reveal the known in
vivo versus in vitro predictive discrepancies and uncover their potential to
pinpoint (high) nucleosome occupancy. We explore different possible signals
within and beyond the nucleosome length and find that complexity indices are
informative of nucleosome occupancy. We compare against the gold standard
(Kaplan model) and find similar and complementary results with the main
difference that our sequence complexity approach. For example, for high
occupancy, complexity-based scores outperform the Kaplan model for predicting
binding representing a significant advancement in predicting the highest
nucleosome occupancy following a training-free approach.Comment: 8 pages main text (4 figures), 12 total with Supplementary (1 figure
Approximations of Algorithmic and Structural Complexity Validate Cognitive-behavioural Experimental Results
We apply methods for estimating the algorithmic complexity of sequences to
behavioural sequences of three landmark studies of animal behavior each of
increasing sophistication, including foraging communication by ants, flight
patterns of fruit flies, and tactical deception and competition strategies in
rodents. In each case, we demonstrate that approximations of Logical Depth and
Kolmogorv-Chaitin complexity capture and validate previously reported results,
in contrast to other measures such as Shannon Entropy, compression or ad hoc.
Our method is practically useful when dealing with short sequences, such as
those often encountered in cognitive-behavioural research. Our analysis
supports and reveals non-random behavior (LD and K complexity) in flies even in
the absence of external stimuli, and confirms the "stochastic" behaviour of
transgenic rats when faced that they cannot defeat by counter prediction. The
method constitutes a formal approach for testing hypotheses about the
mechanisms underlying animal behaviour.Comment: 28 pages, 7 figures and 2 table
Biology of Applied Digital Ecosystems
A primary motivation for our research in Digital Ecosystems is the desire to
exploit the self-organising properties of biological ecosystems. Ecosystems are
thought to be robust, scalable architectures that can automatically solve
complex, dynamic problems. However, the biological processes that contribute to
these properties have not been made explicit in Digital Ecosystems research.
Here, we discuss how biological properties contribute to the self-organising
features of biological ecosystems, including population dynamics, evolution, a
complex dynamic environment, and spatial distributions for generating local
interactions. The potential for exploiting these properties in artificial
systems is then considered. We suggest that several key features of biological
ecosystems have not been fully explored in existing digital ecosystems, and
discuss how mimicking these features may assist in developing robust, scalable
self-organising architectures. An example architecture, the Digital Ecosystem,
is considered in detail. The Digital Ecosystem is then measured experimentally
through simulations, with measures originating from theoretical ecology, to
confirm its likeness to a biological ecosystem. Including the responsiveness to
requests for applications from the user base, as a measure of the 'ecological
succession' (development).Comment: 9 pages, 4 figure, conferenc
Algorithmic complexity for psychology: A user-friendly implementation of the coding theorem method
Kolmogorov-Chaitin complexity has long been believed to be impossible to
approximate when it comes to short sequences (e.g. of length 5-50). However,
with the newly developed \emph{coding theorem method} the complexity of strings
of length 2-11 can now be numerically estimated. We present the theoretical
basis of algorithmic complexity for short strings (ACSS) and describe an
R-package providing functions based on ACSS that will cover psychologists'
needs and improve upon previous methods in three ways: (1) ACSS is now
available not only for binary strings, but for strings based on up to 9
different symbols, (2) ACSS no longer requires time-consuming computing, and
(3) a new approach based on ACSS gives access to an estimation of the
complexity of strings of any length. Finally, three illustrative examples show
how these tools can be applied to psychology.Comment: to appear in "Behavioral Research Methods", 14 pages in journal
format, R package at http://cran.r-project.org/web/packages/acss/index.htm
SLIDER: Mining correlated motifs in protein-protein interaction networks
Abstract—Correlated motif mining (CMM) is the problem to find overrepresented pairs of patterns, called motif pairs, in interacting protein sequences. Algorithmic solutions for CMM thereby provide a computational method for predicting binding sites for protein interaction. In this paper, we adopt a motif-driven approach where the support of candidate motif pairs is evaluated in the network. We experimentally establish the superiority of the Chi-square-based support measure over other support measures. Furthermore, we obtain that CMM is an NP-hard problem for a large class of support measures (including Chi-square) and reformulate the search for correlated motifs as a combinatorial optimization problem. We then present the method SLIDER which uses local search with a neighborhood function based on sliding motifs and employs the Chi-square-based support measure. We show that SLIDER outperforms existing motif-driven CMM methods and scales to large protein-protein interaction networks
Sequence alignment, mutual information, and dissimilarity measures for constructing phylogenies
Existing sequence alignment algorithms use heuristic scoring schemes which
cannot be used as objective distance metrics. Therefore one relies on measures
like the p- or log-det distances, or makes explicit, and often simplistic,
assumptions about sequence evolution. Information theory provides an
alternative, in the form of mutual information (MI) which is, in principle, an
objective and model independent similarity measure. MI can be estimated by
concatenating and zipping sequences, yielding thereby the "normalized
compression distance". So far this has produced promising results, but with
uncontrolled errors. We describe a simple approach to get robust estimates of
MI from global pairwise alignments. Using standard alignment algorithms, this
gives for animal mitochondrial DNA estimates that are strikingly close to
estimates obtained from the alignment free methods mentioned above. Our main
result uses algorithmic (Kolmogorov) information theory, but we show that
similar results can also be obtained from Shannon theory. Due to the fact that
it is not additive, normalized compression distance is not an optimal metric
for phylogenetics, but we propose a simple modification that overcomes the
issue of additivity. We test several versions of our MI based distance measures
on a large number of randomly chosen quartets and demonstrate that they all
perform better than traditional measures like the Kimura or log-det (resp.
paralinear) distances. Even a simplified version based on single letter Shannon
entropies, which can be easily incorporated in existing software packages, gave
superior results throughout the entire animal kingdom. But we see the main
virtue of our approach in a more general way. For example, it can also help to
judge the relative merits of different alignment algorithms, by estimating the
significance of specific alignments.Comment: 19 pages + 16 pages of supplementary materia
- …