Of mice and men

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Reproductive tract biology: Of mice and men.

The study of male and female reproductive tract development requires expertise in two separate disciplines, developmental biology and endocrinology. For ease of experimentation and economy, the mouse has been used extensively as a model for human development and pathogenesis, and for the most part similarities in developmental processes and hormone action provide ample justification for the relevance of mouse models for human reproductive tract development. Indeed, there are many examples describing the phenotype of human genetic disorders that have a reasonably comparable phenotype in mice, attesting to the congruence between mouse and human development. However, anatomic, developmental and endocrinologic differences exist between mice and humans that (1) must be appreciated and (2) considered with caution when extrapolating information between all animal models and humans. It is critical that the investigator be aware of both the similarities and differences in organogenesis and hormone action within male and female reproductive tracts so as to focus on those features of mouse models with clear relevance to human development/pathology. This review, written by a team with extensive expertise in the anatomy, developmental biology and endocrinology of both mouse and human urogenital tracts, focusses upon the significant human/mouse differences, and when appropriate voices a cautionary note regarding extrapolation of mouse models for understanding development of human male and female reproductive tracts

Of mice and men : financial and occupational differentiation among *Augustales

What was the economic role of *augustales in the large commercial hubs of the Roman Empire? Inscriptions offer us some insight in the structure, size, and usage of the economic capital gathered by them. One leitmotif here is the question of whether the wealth of *augustales aided them in enlarging their social network or in obtaining an honorific position, and therefore furthered their integration in local society. The first section of this paper concerns itself with the importance of occupational and geographical differentiation. How were occupational titles important for the expression of social status? Are there any differences between the "regular" attestations of professions and those who recorded membership of a professional association? Which professions were common among *augustales? In which economic sectors do we encounter them? Are there indications of localised specialisation or geographical differentiation? Here, special attention is given to Ostia and Lugdunum. Finally, were *augustales involved in the imperial grain dole? A second section discusses which expenditures and benefactions express the wealth of *augustales, a proxy for their economic potential. How often do epigraphic attestations offer information on the role of *augustales as benefactors in their cities (and sometimes beyond)? What was the magnitude and typology of the gift? Besides benefactions, other ways were available to *augustales to stress the size of their economic capital. Did these other expenditures and benefactions overlap? How does this relate to other honours and/or privileges taken up by these *augustales

Of Mice and Men

Steinbeck\u27s Of Mice and Men was presented by John Carroll University\u27s Department of Communications on March 30 and 31.https://collected.jcu.edu/plays/1087/thumbnail.jp

Of Mice and Men

John Steinbeck\u27s drama of itinerant workers in California presented at John Carroll University in March of 1990.https://collected.jcu.edu/plays/1042/thumbnail.jp

Of mice and men: Sparse statistical modeling in cardiovascular genomics

In high-throughput genomics, large-scale designed experiments are becoming common, and analysis approaches based on highly multivariate regression and anova concepts are key tools. Shrinkage models of one form or another can provide comprehensive approaches to the problems of simultaneous inference that involve implicit multiple comparisons over the many, many parameters representing effects of design factors and covariates. We use such approaches here in a study of cardiovascular genomics. The primary experimental context concerns a carefully designed, and rich, gene expression study focused on gene-environment interactions, with the goals of identifying genes implicated in connection with disease states and known risk factors, and in generating expression signatures as proxies for such risk factors. A coupled exploratory analysis investigates cross-species extrapolation of gene expression signatures--how these mouse-model signatures translate to humans. The latter involves exploration of sparse latent factor analysis of human observational data and of how it relates to projected risk signatures derived in the animal models. The study also highlights a range of applied statistical and genomic data analysis issues, including model specification, computational questions and model-based correction of experimental artifacts in DNA microarray data.Comment: Published at http://dx.doi.org/10.1214/07-AOAS110 in the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Favorite of Mice and Men

The American public consumes an average of ten pounds of cheese per person each year. If you haven\u27t been eating your share, perhaps it\u27s -time to investigate the more than 400 different kinds of cheese available in supermarkets today

Directing of Mice and Men

The work of the playwright is necessarily an interpretation and reflection of his time. The work of the company in a theatrical production is necessarily an interpretation and reflection of the playwright as he is seen through their own time. These works are readily perceived by the audience in the living theatre experiences through the sensory impressions of their eyes and ears. In contrast to that which the audience perceives, the world of the director is unknown. Despite the fact that he is the premier artistic coordinator, his job is completed when the curtain rises, with the spectators viewing the finished product and knowing little of its inception and creation. This thesis will show what goes into and comes out of tho director\u27s analyzing, interpreting, and mounting of a production of John Steinbeck\u27s Of Mice and Men

Of Mice and Men (program)

Performed July 7-8, 1969. Part of the Summer Theatre Workshop. Cast:George: Larry EppsLennie: Jim FrazerCandy: Morris EllisThe Boxx: Chuck MillerCurley: Mike WiseCurley\u27s Wife: Susan MurraySlim: Larry MenefeeCarlson: Chuck MillerWhit: Dennis CoxCrooks: Moses Rollinshttps://scholarworks.harding.edu/theatre-history/1035/thumbnail.jp