Multislice computed tomography evaluation of primary abdominal fat necrosis : a rare cause of acute abdominal pain

Purpose: Abdominal fat necrosis is a rare cause of abdominal acute pain, classified into primary or secondary according to the cause. Primary fat necrosis includes epiploic appendagitis or idiopathic infarction of the greater omentum. This retrospective study focuses on multislice computed tomography (MSCT) findings and diagnosis of primary abdominal fat necrosis as a cause of acute abdomen. Material and methods: This was a retrospective study with 20 patients included, presented to emergency room with acute abdominal pain diagnosed as primary fat necrosis. Retrospective evaluation was made of the patients' clinical data, presentation, CT studies done at the acute stage, and their primary and final diagnosis. Results: Twenty patients (eight male and 12 female, mean age 45 years, age range 20-70 years) diagnosed with abdominal fat necrosis (primary omental infarct) on CT imaging between October 2014 and June 2018 were evaluated. Clinically, five patients were suspected to be cholecystitis¸ eight patients as appendicitis, and four patients as diverticulitis. In addition, three patients had renal colic and were suspected to have ureteric stones; they showed suspected areas of abnormal fat density in non-contrast CT of the urinary tract. Idiopathic omental infarctions were detected in 13 patients on CT; all were on the right side. Laparoscopic excision was done for all. The other seven patients had epiploic appendagitis, seen on the left side, treated with conservative management. Conclusions: Primary fat necrosis, although rare, can be presented as acute abdomen. MSCT is the main diagnostic tool for diagnosis of omental infraction and differentiation between other causes of acute abdomen

LABRAD : Vol 33, Issue 3 - September 2008

Vitamin D Deficiency: Are We Still Ignoring the Evidence? Collection and Transport of Urine for Culture Understanding and Interpreting Serum Protein Electrophoresis Cystic Fibrosis at a Glance What you need to know about Dengue Infection CT Colonoscopy: Introduction CT Enteroclysis: A New Technique to Evaluate Small Bowel CSF-DR: An Important Diagnostic Tool G6PD Quantification Quality Assurance Clinical Laboratory Continuing Medical Education (CME) Seminars Meeting Reportshttps://ecommons.aku.edu/labrad/1016/thumbnail.jp

Spontaneous Perforation of the Small Intestine, a Novel Manifestation of Classical Homocystinuria in an Adult with New Cystathionine b-synthetase Gene Mutations

The clinical picture of classical homocystinuria is diverse. This is the first report of an adult homocystinuric patient with non-traumatic spontaneous small bowel perforation. A 47-year old man presented with abdominal rebound tenderness, hypotension and tachycardia, anemia, and elevated markers of inflammation. Other routine laboratory tests were normal. Abdominal x-ray showed no free air. An emergency laparotomy revealed jejunal perforation in the left upper quadrant. Histologic specimen showed full-thickness nonspecific inflammation of the intestinal wall with granulocytic infiltration, hemorrhage and necrosis. Tuberculosis, actinomycosis and typhus were histologically and clinically excluded. After excluding all known possible causes of perforation, we presumed a causative relationship between homocystinuria and small bowel perforation. It could be hypothesized that connective tissue weakness in homocystinuria is a result of homocysteine interference with recombinant human fibrillin-1 fragments or cross-linking of collagen through permanent degradation of disulfide bridges and lysine amino acid residues in proteins. DNA analysis showed three detectable mutations in the cystathionine beta-synthetase gene, 1278T:c.833T>C, and two new mutations, V372G:c.1133T>G, and D520G:c.1558A>G in the alternatively spliced exon 15

Beyond the commonest: right lower quadrant abdominal pain is not always appendicitis

Background: Despite acute appendicitis is the most common underlying etiology of the acute abdomen, a considerable list of other pathologies should be considered; despite sharing almost the same clinical presentation. This study aimed to re-enhance the importance and sensitivity of CT scan as a solitary imaging tool, in the evaluation of patients with acute right lower abdominal pain. Patients and methods: It is a retrospective study of the last 1000 patients, referred with acute right lower abdominal pain for CT scan examination. Biphasic CT scan abdomen protocol was applied for all. Results: Cecal carcinoma was detected in three patients (0.3%), epiploic appendicitis in five (0.5%), omental infarct in two (0.2%), appendicular mucocele in two (0.2%), appendicular NET in one (0.1%), cecal diverticulitis in four (0.4%), Chron’s disease in six (0.6%), intussusception in one (0.1%) and FB in one (0.1%) and appendicular perforation in one (0.1%), acute simple appendicitis 398 (39.8%) and 577 (57.7%) were unremarkable. Conclusion: Despite acute appendicitis is the most common cause of the acute abdomen, many other surgical and non-surgical etiologies should also be considered, with a higher sensitivity of CT as a solitary diagnostic tool of imaging

Maladies péritonéales : place et apport de l'imagerie par résonance magnétique

Magnetic resonance imaging (MRI) allows news approaches to improve diagnostic and therapeutic issues related to peritoneal diseases. This technique requires using dedicated protocols and has a learning curve. After a literature review on peritoneal imaging highlighting the role of MRI and its potential underutilization, the purpose of this work was to study the contribution of MRI in two models of diffuse peritoneal diseases. The first model concerned endometriosis. Using dedicated protocols, studies on digestive and diaphragmatic involvements reported high performance for providing a useful mapping of lesions for both diagnosis and surgical planning. The second model concerned peritoneal carcinomatosis. The purpose was to assess the contribution of MRI in selecting patients for curative surgery. The first study, performed in a large cohort, reported a very low impact of the different imaging techniques in the selection of non-resectable patients. Using a new approach combining MRI and computed tomography (CT), the second study demonstrated a substantial improvement in quantitative lesion assessment, although remaining sub optimal. With a qualitative approach evaluating signs of non-resectability, the third study showed MRI had better sensitivity than CT for the detection of non-resecable small bowel involvements in pseudomyxoma peritonei. MRI, thanks to its high contrast resolution, provides unique information. Used as reference technique or in addition to other techniques, MRI optimizes patient managementDe nouvelles approches sont possibles en imagerie par résonance magnétique (IRM) pour répondre aux principaux enjeux diagnostiques et thérapeutiques liés aux maladies péritonéales. Cette technique implique l'utilisation de protocoles dédiés et une courbe d'apprentissage. Après une revue de la littérature sur l'imagerie péritonéale mettant en perspective la place de l'IRM et sa potentielle sous utilisation, l'objectif de ce travail a été d'étudier l'apport de cette technique dans deux modèles de maladies péritonéales diffuses. Le premier modèle concernait l'endométriose. En utilisant des protocoles adaptés, les études sur les atteintes digestives et diaphragmatiques ont démontré qu'une cartographie lésionnelle utile au diagnostic et à la prise en charge chirurgicale gynécologique pouvait être obtenue avec de hauts niveaux de performance. Le second modèle concernait la carcinose. La problématique était d'évaluer l'apport de l'IRM dans la sélection des patients candidats à une chirurgie menée à visée curative. La première étude menée sur une grande cohorte a démontré un très faible impact des différentes techniques d'imagerie dans la sélection des patients non résécables. La seconde étude, proposant une nouvelle approche de la quantification des lésions en combinant l'IRM au scanner, a rapporté une amélioration relative du bilan lésionnel, bien qu'encore infra optimale. Avec une approche qualitative centrée sur la recherche de signes de non résécabilité, la troisième étude a démontré que l'IRM avait une meilleure sensibilité que le scanner pour détecter les atteintes non résécables de l'intestin grêle dans le pseudomyxome péritonéal. L'IRM, grâce à sa haute résolution en contraste, offre des informations uniques. Utilisée comme technique de référence ou en complément des autres techniques en fonction de la nature des lésions à explorer, elle permet d'optimiser la prise en charge des patient