Detection of retinal vascular bifurcations by trainable v4-like filters

The detection of vascular bifurcations in retinal fundus images is important for finding signs of various cardiovascular diseases. We propose a novel method to detect such bifurcations. Our method is implemented in trainable filters that mimic the properties of shape-selective neurons in area V4 of visual cortex. Such a filter is configured by combining given channels of a bank of Gabor filters in an AND-gate-like operation. Their selection is determined by the automatic analysis of a bifurcation feature that is specified by the user from a training image. Consequently, the filter responds to the same and similar bifurcations. With only 25 filters we achieved a correct detection rate of 98.52% at a precision rate of 95.19% on a set of 40 binary fundus images, containing more than 5000 bifurcations. In principle, all vascular bifurcations can be detected if a sufficient number of filters are configured and used.peer-reviewe

Multispectral MRI centerline tracking in carotid arteries

We propose a minimum cost path approach to track the centerlines of the internal and external carotid arteries in multispectral MR data. User interaction is limited to the annotation of three seed points. The cost image is based on both a measure of vessel medialness and lumen intensity similarity in two MRA image sequences: Black Blood MRA and Phase Contrast MRA. After intensity inhomogeneity correction and noise reduction, the two images are aligned using affine registration. The two parameters that control the contrast of the cost image were determined in an optimization experiment on 40 training datasets. Experiments on the training datasets also showed that a cost image composed of a combination of gradient-based medialness and lumen intensity similarity increases the tracking accuracy compared to using only one of the constituents. Furthermore, centerline tracking using both MRA sequences outperformed tracking using only one of these MRA images. An independent test set of 152 images from 38 patients served to validate the technique. The centerlines of 148 images were successfully extracted using the parameters optimized on the training sets. The average mean distance to the reference standard, manually annotated centerlines, was 0.98 mm, which is comparable to the in-plane resolution. This indicates that the proposed method has a high potential to replace the manual centerline annotation.Image Science and TechnologyApplied Science

Image Analysis of the Carotid Artery: A (Semi-)Automatic Approach

In this thesis we presented several (semi-)automatic image processing techniques for analyzing the carotid artery wall and carotid artery plaque in MRI and Ultrasound. The presented methods include image segmentation, registration, centerline extraction, and quantification