Simulation methods for reliability-based design optimization and model updating of civil engineering structures and systems

This thesis presents a collection of original contributions pertaining to the subjects of reliability-based design optimization (RBDO) and model updating of civil engineering structures and systems. In this regard, probability theory concepts and tools are instrumental in the formulation of the herein reported developments. Firstly, two approaches are devised for the RBDO of structural dynamical systems under stochastic excitation. Namely, a stochastic search technique is proposed for constrained and unconstrained RBDO problems involving continuous, discrete and mixed discrete-continuous design spaces, whereas an efficient sensitivity assessment framework for linear stochastic structures is implemented to identify optimal designs and evaluate their sensitivities. Moreover, two classes of model updating problems are considered. In this context, the Bayesian interpretation of probability theory plays a key role in the proposed solution schemes. Specifically, contaminant source detection in water distribution networks is addressed by resorting to a sampling-based Bayesian model class selection framework. Furthermore, an effective strategy for Bayesian model updating with structural reliability methods is presented to treat identification problems involving structural dynamical systems, measured response data, and high-dimensional parameter spaces. The approaches proposed in this thesis integrate stochastic simulation techniques as an essential part of their formulation, which allows obtaining non-trivial information about the systems of interest as a byproduct of the solution processes. Overall, the findings presented in this thesis suggest that the reported methods can be potentially adopted as supportive tools for a number of practical decision-making processes in civil engineering.Diese Arbeit stellt eine Sammlung von Beiträgen vor, die sich mit der Reliability-based-Design-Optimization (RBDO) und dem Model updating von Strukturen und Systemen im Bauwesen befassen. In diesem Zusammenhang sind wahrscheinlichkeitstheoretische Konzepte für die Formulierung der hier vorgestellten Entwicklungen von entscheidender Bedeutung. Zunächst werden zwei Ansätze für eine RBDO von strukturdynamischen Systemen unter stochastischer Anregung entwickelt. Es wird eine stochastische Suchtechnik für beschränkte und unbeschränkte RBDO-Probleme vorgeschlagen. Diese beziehen kontinuierliche, diskrete und gemischt diskret-kontinuierliche Designräume ein. Gleichzeitig wird ein effizientes Framework zur Bewertung der Sensitivität lineare stochastische Strukturen implementiert, um optimale Designs zu identifizieren und ihre Sensitivitäten zu bewerten. Darüber hinaus werden zwei Klassen von Problem aus dem Model updating betrachtet. Der Fokus wird hierbei auf die Erkennung von Kontaminationsquellen in Wasserverteilungsnetzen mithilfe eines auf Stichproben basierenden Bayesian-Model-Class-selection-Framework gelegt. Ferner wird eine effektive Strategie zur Bearbeitung von Problemen des Bayesian-Model-updating, die strukturdynamischen Systeme, gemessene Systemantwortdaten und hochdimensionale Parameterräume umfassen, vorgestellt. Die beschriebenen Ansätze verwenden stochastische Simulationstechniken als wesentlicher Bestandteil ihrer Formulierung, wodurch nicht-triviale Informationen über betrachtete Systeme als Nebenprodukt der Lösungsprozesse gewonnen werden können. Insgesamt deuten die vorgestellten Ergebnisse dieser Arbeit darauf hin, dass die beschriebenen Methoden potenziell als unterstützende Elemente in praktischen Entscheidungsproblemen im Zusammenhang mit Strukturen und Systemen im Bauwesen eingesetzt werden können

Basic Research Needs for Geosciences: Facilitating 21st Century Energy Systems

Executive Summary Serious challenges must be faced in this century as the world seeks to meet global energy needs and at the same time reduce emissions of greenhouse gases to the atmosphere. Even with a growing energy supply from alternative sources, fossil carbon resources will remain in heavy use and will generate large volumes of carbon dioxide (CO2). To reduce the atmospheric impact of this fossil energy use, it is necessary to capture and sequester a substantial fraction of the produced CO2. Subsurface geologic formations offer a potential location for long-term storage of the requisite large volumes of CO2. Nuclear energy resources could also reduce use of carbon-based fuels and CO2 generation, especially if nuclear energy capacity is greatly increased. Nuclear power generation results in spent nuclear fuel and other radioactive materials that also must be sequestered underground. Hence, regardless of technology choices, there will be major increases in the demand to store materials underground in large quantities, for long times, and with increasing efficiency and safety margins. Rock formations are composed of complex natural materials and were not designed by nature as storage vaults. If new energy technologies are to be developed in a timely fashion while ensuring public safety, fundamental improvements are needed in our understanding of how these rock formations will perform as storage systems. This report describes the scientific challenges associated with geologic sequestration of large volumes of carbon dioxide for hundreds of years, and also addresses the geoscientific aspects of safely storing nuclear waste materials for thousands to hundreds of thousands of years. The fundamental crosscutting challenge is to understand the properties and processes associated with complex and heterogeneous subsurface mineral assemblages comprising porous rock formations, and the equally complex fluids that may reside within and flow through those formations. The relevant physical and chemical interactions occur on spatial scales that range from those of atoms, molecules, and mineral surfaces, up to tens of kilometers, and time scales that range from picoseconds to millennia and longer. To predict with confidence the transport and fate of either CO2 or the various components of stored nuclear materials, we need to learn to better describe fundamental atomic, molecular, and biological processes, and to translate those microscale descriptions into macroscopic properties of materials and fluids. We also need fundamental advances in the ability to simulate multiscale systems as they are perturbed during sequestration activities and for very long times afterward, and to monitor those systems in real time with increasing spatial and temporal resolution. The ultimate objective is to predict accurately the performance of the subsurface fluid-rock storage systems, and to verify enough of the predicted performance with direct observations to build confidence that the systems will meet their design targets as well as environmental protection goals. The report summarizes the results and conclusions of a Workshop on Basic Research Needs for Geosciences held in February 2007. Five panels met, resulting in four Panel Reports, three Grand Challenges, six Priority Research Directions, and three Crosscutting Research Issues. The Grand Challenges differ from the Priority Research Directions in that the former describe broader, long-term objectives while the latter are more focused

Smart Urban Water Networks

This book presents the paper form of the Special Issue (SI) on Smart Urban Water Networks. The number and topics of the papers in the SI confirm the growing interest of operators and researchers for the new paradigm of smart networks, as part of the more general smart city. The SI showed that digital information and communication technology (ICT), with the implementation of smart meters and other digital devices, can significantly improve the modelling and the management of urban water networks, contributing to a radical transformation of the traditional paradigm of water utilities. The paper collection in this SI includes different crucial topics such as the reliability, resilience, and performance of water networks, innovative demand management, and the novel challenge of real-time control and operation, along with their implications for cyber-security. The SI collected fourteen papers that provide a wide perspective of solutions, trends, and challenges in the contest of smart urban water networks. Some solutions have already been implemented in pilot sites (i.e., for water network partitioning, cyber-security, and water demand disaggregation and forecasting), while further investigations are required for other methods, e.g., the data-driven approaches for real time control. In all cases, a new deal between academia, industry, and governments must be embraced to start the new era of smart urban water systems

National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program 1988, volume 1

The 1988 Johnson Space Center (JSC) National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program was conducted by the University of Houston and JSC. The 10-week program was operated under the auspices of the ASEE. The program at JSC, as well as the programs at other NASA Centers, was funded by the Office of University Affairs, NASA Headquarters, Washington, D.C. The objectives of the program, which began in 1965 at JSC and in 1964 nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of participants' institutions; and (4) to contribute to the research objectives of the NASA Centers

Quantification and Simulation of Liquid Chromatography-Mass Spectrometry Data

Computational mass spectrometry is a fast evolving field that has attracted increased attention over the last couple of years. The performance of software solutions determines the success of analysis to a great extent. New algorithms are required to reflect new experimental procedures and deal with new instrument generations. One essential component of algorithm development is the validation (as well as comparison) of software on a broad range of data sets. This requires a gold standard (or so-called ground truth), which is usually obtained by manual annotation of a real data set. Comprehensive manually annotated public data sets for mass spectrometry data are labor-intensive to produce and their quality strongly depends on the skill of the human expert. Some parts of the data may even be impossible to annotate due to high levels of noise or other ambiguities. Furthermore, manually annotated data is usually not available for all steps in a typical computational analysis pipeline. We thus developed the most comprehensive simulation software to date, which allows to generate multiple levels of ground truth and features a plethora of settings to reflect experimental conditions and instrument settings. The simulator is used to generate several distinct types of data. The data are subsequently employed to evaluate existing algorithms. Additionally, we employ simulation to determine the influence of instrument attributes and sample complexity on the ability of algorithms to recover information. The results give valuable hints on how to optimize experimental setups. Furthermore, this thesis introduces two quantitative approaches, namely a decharging algorithm based on integer linear programming and a new workflow for identification of differentially expressed proteins for a large in vitro study on toxic compounds. Decharging infers the uncharged mass of a peptide (or protein) by clustering all its charge variants. The latter occur frequently under certain experimental conditions. We employ simulation to show that decharging is robust against missing values even for high complexity data and that the algorithm outperforms other solutions in terms of mass accuracy and run time on real data. The last part of this thesis deals with a new state-of-the-art workflow for protein quantification based on isobaric tags for relative and absolute quantitation (iTRAQ). We devise a new approach to isotope correction, propose an experimental design, introduce new metrics of iTRAQ data quality, and confirm putative properties of iTRAQ data using a novel approach. All tools developed as part of this thesis are implemented in OpenMS, a C++ library for computational mass spectrometry