Multimodal non-linear latent semantic method for information retrieval

La búsqueda y recuperación de datos multimodales es una importante tarea dentro del campo de búsqueda y recuperación de información, donde las consultas y los elementos de la base de datos objetivo están representados por un conjunto de modalidades, donde cada una de ellas captura un aspecto de un fenómeno de interés. Cada modalidad contiene información complementaria y común a otras modalidades. Con el fin de tomar ventaja de la información adicional distribuida a través de las distintas modalidades han sido desarrollados muchos algoritmos y métodos que utilizan las propiedades estadísticas en los datos multimodales para encontrar correlaciones implícitas, otros aprenden a calcular distancias heterogéneas, otros métodos aprenden a proyectar los datos desde el espacio de entrada hasta un espacio semántico común, donde las diferentes modalidades son comparables y se puede construir un ranking a partir de ellas. En esta tesis se presenta el diseño de un sistema para la búsqueda y recuperación de información multimodal que aprende varias proyecciones no lineales a espacios semánticos latentes donde las distintas modalidades son representadas en conjunto y es posible realizar comparaciones y medidas de similitud para construir rankings multimodales. Adicionalmente se propone un método kernelizado para la proyección de datos a un espacio semántico latente usando la información de las etiquetas como método de supervisión para construir índice multimodal que integra los datos multimodales y la información de las etiquetas; este método puede proyectar los datos a tres diferentes espacios semánticos donde varias configuraciones de búsqueda y recuperación de información pueden ser aplicadas. El sistema y el método propuestos fueron evaluados en un conjunto de datos compuesto por casos médicos, donde cada caso consta de una imagen de tejido prostático, un reporte de texto del patólogo y un valor de Gleason score como etiqueta de supervisión. Combinando la información multimodal y la información en las etiquetas se generó un índice multimodal que se utilizó para realizar la tarea de búsqueda y recuperación de información por contenido obteniendo resultados sobresalientes. Las proyecciones no-lineales permiten al modelo una mayor flexibilidad y capacidad de representación. Sin embargo calcular estas proyecciones no-lineales en un conjunto de datos enorme es computacionalmente costoso, para reducir este costo y habilitar el modelo para procesar datos a gran escala, la técnica del budget fue utilizada, mostrando un buen compromiso entre efectividad y velocidad.Multimodal information retrieval is an information retrieval sub-task where queries and database target elements are composed of several modalities or views. A modality is a representation of complex phenomena, captured and measured by different sensors or information sources, each one encodes some information about it. Each modality representation contains complementary and shared information about the phenomenon of interest, this additional information can be used to improve the information retrieval process. Several methods have been developed to take advantage of additional information distributed across different modalities. Some of them exploit statistical properties in multimodal data to find correlations and implicit relationships, others learn heterogeneous distance functions, and others learn linear and non-linear projections that transform data from the original input space to a common latent semantic space where different modalities are comparable. In spite of the attention dedicated to this issue, multimodal information retrieval is still an open problem. This thesis presents a multimodal information retrieval system designed to learn several mapping functions to transform multimodal data to a latent semantic space, where different modalities are combined and can be compared to build a multimodal ranking and perform a multimodal information retrieval task. Additionally, a multimodal kernelized latent semantic embedding method is proposed to construct a supervised multimodal index, integrating multimodal data and label supervision. This method can perform mappings to three different spaces where some information retrieval task setups can be performed. The proposed system and method were evaluated in a multimodal medical case-based retrieval task where data is composed of whole-slide images of prostate tissue samples, pathologist’s text report and Gleason score as a supervised label. Multimodal data and labels were combined to produce a multimodal index. This index was used to retrieve multimodal information and achieves outstanding results compared with previous works on this topic. Non-linear mappings provide more flexibility and representation capacity to the proposed model. However, constructing the non-linear mapping in a large dataset using kernel methods can be computationally costly. To reduce the cost and allow large scale applications, the budget technique was introduced, showing good performance between speed and effectiveness.COLCIENCIASJóvenes investigadores 761/2016Línea de investigación: Ciencias de la computaciónMaestrí

Breast Cancer Classification from Histopathological Images Using Transfer Learning and Deep Neural Networks

Early diagnosis of breast cancer is the most reliable and practical approach to managing cancer. Computer-aided detection or computer-aided diagnosis is one of the software technology designed to assist doctors in detecting or diagnose cancer and reduce mortality via using the medical image analysis with less time. Recently, medical image analysis used Convolution Neural Networks to evaluate a vast number of data to detect cancer cells or image classification. In this thesis, we implemented transfer learning from pre-trained deep neural networks ResNet18, Inception-V3Net, and ShuffleNet in terms of binary classification and multiclass classification for breast cancer from histopathological images. We use transfer learning with the fine-tuned network results in much faster and less complicated training than a training network with randomly initialized weights from scratch. Our approach is applied to image-based breast cancer classification using histopathological images from public dataset BreakHis. The highest average accuracy achieved for binary classification of benign or malignant cases was 97.11% for ResNet 18, followed by 96.78% for ShuffleNet and 95.65% for Inception-V3Net. In terms of the multiclass classification of eight cancer classes, the average accuracies for pre-trained networks are as follows. ResNet18 achieved 94.17%, Inception-V3Net 92.76% and ShuffleNet 92.27%

AI in Medical Imaging Informatics: Current Challenges and Future Directions

This paper reviews state-of-the-art research solutions across the spectrum of medical imaging informatics, discusses clinical translation, and provides future directions for advancing clinical practice. More specifically, it summarizes advances in medical imaging acquisition technologies for different modalities, highlighting the necessity for efficient medical data management strategies in the context of AI in big healthcare data analytics. It then provides a synopsis of contemporary and emerging algorithmic methods for disease classification and organ/ tissue segmentation, focusing on AI and deep learning architectures that have already become the de facto approach. The clinical benefits of in-silico modelling advances linked with evolving 3D reconstruction and visualization applications are further documented. Concluding, integrative analytics approaches driven by associate research branches highlighted in this study promise to revolutionize imaging informatics as known today across the healthcare continuum for both radiology and digital pathology applications. The latter, is projected to enable informed, more accurate diagnosis, timely prognosis, and effective treatment planning, underpinning precision medicine