Informatics for EEG biomarker discovery in clinical neuroscience

Neurological and developmental disorders (NDDs) impose an enormous burden of disease on children throughout the world. Two of the most common are autism spectrum disorder (ASD) and epilepsy. ASD has recently been estimated to affect 1 in 68 children, making it the most common neurodevelopmental disorder in children. Epilepsy is also a spectrum disorder that follows a developmental trajectory, with an estimated prevalence of 1%, nearly as common as autism. ASD and epilepsy co-occur in approximately 30% of individuals with a primary diagnosis of either disorder. Although considered to be different disorders, the relatively high comorbidity suggests the possibility of common neuropathological mechanisms. Early interventions for NDDs lead to better long-term outcomes. But early intervention is predicated on early detection. Behavioral measures have thus far proven ineffective in detecting autism before about 18 months of age, in part because the behavioral repertoire of infants is so limited. Similarly, no methods for detecting emerging epilepsy before seizures begin are currently known. Because atypical brain development is likely to precede overt behavioral manifestations by months or even years, a critical developmental window for early intervention may be opened by the discovery of brain based biomarkers. Analysis of brain activity with EEG may be under-utilized for clinical applications, especially for neurodevelopment. The hypothesis investigated in this dissertation is that new methods of nonlinear signal analysis, together with methods from biomedical informatics, can extract information from EEG data that enables detection of atypical neurodevelopment. This is tested using data collected at Boston Children’s Hospital. Several results are presented. First, infants with a family history of ASD were found to have EEG features that may enable autism to be detected as early as 9 months. Second, significant EEG-based differences were found between children with absence epilepsy, ASD and control groups using short 30-second EEG segments. Comparison of control groups using different EEG equipment supported the claim that EEG features could be computed that were independent of equipment and lab conditions. Finally, the potential for this technology to help meet the clinical need for neurodevelopmental screening and monitoring in low-income regions of the world is discussed

Recent Applications in Graph Theory

Graph theory, being a rigorously investigated field of combinatorial mathematics, is adopted by a wide variety of disciplines addressing a plethora of real-world applications. Advances in graph algorithms and software implementations have made graph theory accessible to a larger community of interest. Ever-increasing interest in machine learning and model deployments for network data demands a coherent selection of topics rewarding a fresh, up-to-date summary of the theory and fruitful applications to probe further. This volume is a small yet unique contribution to graph theory applications and modeling with graphs. The subjects discussed include information hiding using graphs, dynamic graph-based systems to model and control cyber-physical systems, graph reconstruction, average distance neighborhood graphs, and pure and mixed-integer linear programming formulations to cluster networks

Brain health in diverse settings : How age, demographics and cognition shape brain function

Peer reviewe

Brain-Computer Interface

Brain-computer interfacing (BCI) with the use of advanced artificial intelligence identification is a rapidly growing new technology that allows a silently commanding brain to manipulate devices ranging from smartphones to advanced articulated robotic arms when physical control is not possible. BCI can be viewed as a collaboration between the brain and a device via the direct passage of electrical signals from neurons to an external system. The book provides a comprehensive summary of conventional and novel methods for processing brain signals. The chapters cover a range of topics including noninvasive and invasive signal acquisition, signal processing methods, deep learning approaches, and implementation of BCI in experimental problems

Modeling, Predicting and Capturing Human Mobility

Realistic models of human mobility are critical for modern day applications, specifically for recommendation systems, resource planning and process optimization domains. Given the rapid proliferation of mobile devices equipped with Internet connectivity and GPS functionality today, aggregating large sums of individual geolocation data is feasible. The thesis focuses on methodologies to facilitate data-driven mobility modeling by drawing parallels between the inherent nature of mobility trajectories, statistical physics and information theory. On the applied side, the thesis contributions lie in leveraging the formulated mobility models to construct prediction workflows by adopting a privacy-by-design perspective. This enables end users to derive utility from location-based services while preserving their location privacy. Finally, the thesis presents several approaches to generate large-scale synthetic mobility datasets by applying machine learning approaches to facilitate experimental reproducibility

Modeling Human Mobility Entropy as a Function of Spatial and Temporal Quantizations

The knowledge of human mobility is an integral component of several different branches of research and planning, including delay tolerant network routing, cellular network planning, disease prevention, and urban planning. The uncertainty associated with a person's movement plays a central role in movement predictability studies. The uncertainty can be quantified in a succinct manner using entropy rate, which is based on the information theoretic entropy. The entropy rate is usually calculated from past mobility traces. While the uncertainty, and therefore, the entropy rate depend on the human behavior, the entropy rate is not invariant to spatial resolution and sampling interval employed to collect mobility traces. The entropy rate of a person is a manifestation of the observable features in the person's mobility traces. Like entropy rate, these features are also dependent on spatio-temporal quantization. Different mobility studies are carried out using different spatio-temporal quantization, which can obscure the behavioral differences of the study populations. But these behavioral differences are important for population-specific planning. The goal of dissertation is to develop a theoretical model that will address this shortcoming of mobility studies by separating parameters pertaining to human behavior from the spatial and temporal parameters

Complexity Measures and Features for Times Series classification

Classification of time series is a growing problem in different disciplines due to the progressive digitalization of the world. Currently, the state-of-the-art in time series classification is dominated by The Hierarchical Vote Collective of Transformation-based Ensembles. This algorithm is composed of several classifiers of different domains distributed in five large modules. The combination of the results obtained by each module weighed based on an internal evaluation process allows this algorithm to obtain the best results in state-of-the-art. One Nearest Neighbour with Dynamic Time Warping remains the base classifier in any time series classification problem for its simplicity and good results. Despite their performance, they share a weakness, which is that they are not interpretable. In the field of time series classification, there is a tradeoff between accuracy and interpretability. In this work, we propose a set of characteristics capable of extracting information on the structure of the time series to face time series classification problems. The use of these characteristics allows the use of traditional classification algorithms in time series problems. The experimental results of our proposal show no statistically significant differences from the second and third best models of the state-of-the-art. Apart from competitive results in accuracy, our proposal is able to offer interpretable results based on the set of characteristics proposed.Spanish Government TIN2016-81113-R PID2020-118224RB-I00 BES-2017-080137Andalusian Regional Government, Spain P12-TIC-2958 P18-TP-5168 A-TIC-388-UGR-1

Dynamical Systems

Complex systems are pervasive in many areas of science integrated in our daily lives. Examples include financial markets, highway transportation networks, telecommunication networks, world and country economies, social networks, immunological systems, living organisms, computational systems and electrical and mechanical structures. Complex systems are often composed of a large number of interconnected and interacting entities, exhibiting much richer global scale dynamics than the properties and behavior of individual entities. Complex systems are studied in many areas of natural sciences, social sciences, engineering and mathematical sciences. This special issue therefore intends to contribute towards the dissemination of the multifaceted concepts in accepted use by the scientific community. We hope readers enjoy this pertinent selection of papers which represents relevant examples of the state of the art in present day research. [...