Global supply chains of high value low volume products

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From conceptual design to process design optimization: a review on flowsheet synthesis

International audienceThis paper presents the authors’ perspectives on some of the open questions and opportunities in Process Systems Engineering (PSE) focusing on process synthesis. A general overview of process synthesis is given, and the difference between Conceptual Design (CD) and Process Design (PD) is presented using an original ternary diagram. Then, a bibliometric analysis is performed to place major research team activities in the latter. An analysis of ongoing work is conducted and some perspectives are provided based on the analysis. This analysis includes symbolic knowledge representation concepts and inference techniques, i.e., ontology, that is believed to become useful in the future. Future research challenges that process synthesis will have to face, such as biomass transformation, shale production, response to spaceflight demand, modular plant design, and intermittent production of energy, are also discussed

Optimal management of bio-based energy supply chains under parametric uncertainty through a data-driven decision-support framework

This paper addresses the optimal management of a multi-objective bio-based energy supply chain network subjected to multiple sources of uncertainty. The complexity to obtain an optimal solution using traditional uncertainty management methods dramatically increases with the number of uncertain factors considered. Such a complexity produces that, if tractable, the problem is solved after a large computational effort. Therefore, in this work a data-driven decision-making framework is proposed to address this issue. Such a framework exploits machine learning techniques to efficiently approximate the optimal management decisions considering a set of uncertain parameters that continuously influence the process behavior as an input. A design of computer experiments technique is used in order to combine these parameters and produce a matrix of representative information. These data are used to optimize the deterministic multi-objective bio-based energy network problem through conventional optimization methods, leading to a detailed (but elementary) map of the optimal management decisions based on the uncertain parameters. Afterwards, the detailed data-driven relations are described/identified using an Ordinary Kriging meta-model. The result exhibits a very high accuracy of the parametric meta-models for predicting the optimal decision variables in comparison with the traditional stochastic approach. Besides, and more importantly, a dramatic reduction of the computational effort required to obtain these optimal values in response to the change of the uncertain parameters is achieved. Thus the use of the proposed data-driven decision tool promotes a time-effective optimal decision making, which represents a step forward to use data-driven strategy in large-scale/complex industrial problems.Peer ReviewedPostprint (published version

Decision support for build-to-order supply chain management through multiobjective optimization

This paper aims to identify the gaps in decision-making support based on multiobjective optimization for build-to-order supply chain management (BTOSCM). To this end, it reviews the literature available on modelling build-to-order supply chains (BTO-SC) with the focus on adopting multiobjective optimization (MOO) techniques as a decision support tool. The literature has been classified based on the nature of the decisions in different part of the supply chain, and the key decision areas across a typical BTO-SC are discussed in detail. Available software packages suitable for supporting decision making in BTO supply chains are also identified and their related solutions are outlined. The gap between the modelling and optimization techniques developed in the literature and the decision support needed in practice are highlighted and future research directions to better exploit the decision support capabilities of MOO are proposed

Integrated management of chemical processes in a competitive environment

El objetivo general de esta Tesis es mejorar el proceso de la toma de decisiones en la gestión de cadenas de suministro, tomando en cuenta principalmente dos diferencias: ser competitivo considerando las decisiones propias de la cadena de suministro, y ser competitivo dentro de un entorno global. La estructura de ésta tesis se divide en 4 partes principales: La Parte I consiste en una introducción general de los temas cubiertos en esta Tesis (Capítulo 1). Una revisión de la literatura, que nos permite identificar las problemáticas asociadas al proceso de toma de decisiones (Capítulo 2). El Capítulo 3 presenta una introducción de las técnicas y métodos de optimización utilizados para resolver los problemas propuestos en esta Tesis. La Parte II se enfoca en la integración de los niveles de decisión, buscando mejorar la toma de decisiones de la propia cadena de suministro. El Capítulo 4 presenta una formulación matemática que integra las decisiones de síntesis de procesos y las decisiones operacionales. Además, este capítulo presenta un modelo integrado para la toma de decisiones operacionales incluyendo las características del control de procesos. El Capítulo 5 muestra la integración de las decisiones del nivel táctico y el operacional, dicha propuesta está basada en el conocimiento adquirido capturando la información relacionada al nivel operacional. Una vez obtenida esta información se incluye en la toma de decisiones a nivel táctico. Finalmente en el capítulo 6 se desarrolla un modelo simplificado para integrar múltiples cadenas de suministro. El modelo propuesto incluye la información detallada de las entidades presentes en una cadena de suministro (suministradores, plantas de producción, distribuidores y mercados) introduciéndola en un modelo matemático para su coordinación. La Parte III propone la integración explicita de múltiples cadenas de suministro que tienen que enfrentar numerosas situaciones propias de un mercado global. Asimismo, esta parte presenta una nueva herramienta de optimización basada en el uso integrado de métodos de programación matemática y conceptos relacionados a la Teoría de Juegos. En el Capítulo 7 analiza múltiples cadenas de suministro que cooperan o compiten por la demanda global del mercado. El Capítulo 8 incluye una comparación entre el problema resuelto en el Capítulo anterior y un modelo estocástico, los resultados obtenidos nos permiten situar el comportamiento de los competidores como fuente exógena de la incertidumbre típicamente asociada la demanda del mercado. Además, los resultados de ambos Capítulos muestran una mejora sustancial en el coste total de las cadenas de suministro asociada al hecho de cooperar para atender de forma conjunta la demanda disponible. Es por esto, que el Capítulo 9 presenta una nueva herramienta de negociación, basada en la resolución del mismo problema (Capítulo 7) bajo un análisis multiobjetivo. Finalmente, la parte IV presenta las conclusiones finales y una descripción general del trabajo futuro.This Thesis aims to enhance the decision making process in the SCM, remarking the difference between optimizing the SC to be competitive by its own, and to be competitive in a global market in cooperative and competitive environments. The structure of this work has been divided in four main parts: Part I: consists in a general introduction of the main topics covered in this manuscript (Chapter I); a review of the State of the Art that allows us to identify new open issues in the PSE (Chapter 2). Finally, Chapter 3 introduces the main optimization techniques and methods used in this contribution. Part II focuses on the integration of decision making levels in order to improve the decision making of a single SC: Chapter 4 presents a novel formulation to integrate synthesis and scheduling decision making models, additionally, this chapter also shows an integrated operational and control decision making model for distributed generations systems (EGS). Chapter 5 shows the integration of tactical and operational decision making levels. In this chapter a knowledge based approach has been developed capturing the information related to the operational decision making level. Then, this information has been included in the tactical decision making model. In Chapter 6 a simplified approach for integrated SCs is developed, the detailed information of the typical production‐distribution SC echelons has been introduced in a coordinated SC model. Part III proposes the explicit integration of several SC’s decision making in order to face several real market situations. As well, a novel formulation is developed using an MILP model and Game Theory (GT) as a decision making tool. Chapter 7 includes the tactical and operational analysis of several SC’s cooperating or competing for the global market demand. Moreover, Chapter 8 includes a comparison, based on the previous results (MILP‐GT optimization tool) and a two stage stochastic optimization model. Results from both Chapters show how cooperating for the global demand represent an improvement of the overall total cost. Consequently, Chapter 9 presents a bargaining tool obtained by the Multiobjective (MO) resolution of the model presented in Chapter 7. Finally, final conclusions and further work have been provided in Part IV.Postprint (published version

A contribution to support decision making in energy/water sypply chain optimisation

The seeking of process sustainability forces enterprises to change their operations. Additionally, the industrial globalization implies a very dynamic market that, among other issues, promotes the enterprises competition. Therefore, the efficient control and use of their Key Performance Indicators, including profitability, cost reduction, demand satisfaction and environmental impact associated to the development of new products, is a significant challenge. All the above indicators can be efficiently controlled through the Supply Chain Management. Thus, companies work towards the optimization of their individual operations under competitive environments taking advantage of the flexibility provided by the virtually inexistent world market restrictions. This is achieved by the coordination of the resource flows, across all the entities and echelons belonging to the system network. Nevertheless, such coordination is significantly complicated if considering the presence of uncertainty and even more if seeking for a win-win outcome. The purpose of this thesis is extending the current decision making strategies to expedite these tasks in industrial processes. Such a contribution is based on the development of efficient mathematical models that allows coordinating large amount of information synchronizing the production and distribution tasks in terms of economic, environmental and social criteria. This thesis starts presents an overview of the requirements of sustainable production processes, describing and analyzing the current methods and tools used and identifying the most relevant open issues. All the above is always within the framework of Process System Engineering literature. The second part of this thesis is focused in stressing the current Multi-Objective solution strategies. During this part, first explores how the profitability of the Supply Chain can be enhanced by considering simultaneously multiple objectives under demand uncertainties. Particularly, solution frameworks have been proposed in which different multi-criteria decision making strategies have been combined with stochastic approaches. Furthermore, additional performance indicators (including financial and operational ones) have been included in the same solution framework to evaluate its capabilities. This framework was also applied to decentralized supply chains problems in order to explore its capabilities to produce solution that improves the performances of each one of the SC entities simultaneously. Consequently, a new generalized mathematical formulation which integrates many performance indicators in the production process within a supply chain is efficiently solved. Afterwards, the third part of the thesis extends the proposed solution framework to address the uncertainty management. Particularly, the consideration of different types and sources of uncertainty (e.g. external and internal ones) where considered, through the implementation of preventive approaches. This part also explores the use of solution strategies that efficiently selects the number of scenarios that represent the uncertainty conditions. Finally, the importance and effect of each uncertainty source over the process performance is detailed analyzed through the use of surrogate models that promote the sensitivity analysis of those uncertainties. The third part of this thesis is focused on the integration of the above multi-objective and uncertainty approaches for the optimization of a sustainable Supply Chain. Besides the integration of different solution approaches, this part also considers the integration of hierarchical decision levels, by the exploitation of mathematical models that assess the consequences of considering simultaneously design and planning decisions under centralized and decentralized Supply Chains. Finally, the last part of this thesis provides the final conclusions and further work to be developed.La globalización industrial genera un ambiente dinámico en los mercados que, entre otras cosas, promueve la competencia entre corporaciones. Por lo tanto, el uso eficiente de las los indicadores de rendimiento, incluyendo rentabilidad, satisfacción de la demanda y en general el impacto ambiental, representa un area de oportunidad importante. El control de estos indicadores tiene un efecto positivo si se combinan con la gestión de cadena de suministro. Por lo tanto, las compañías buscan definir sus operaciones para permanecer activas dentro de un ambiente competitivo, tomando en cuenta las restricciones en el mercado mundial. Lo anterior puede ser logrado mediante la coordinación de los flujos de recursos a través de todas las entidades y escalones pertenecientes a la red del sistema. Sin embargo, dicha coordinación se complica significativamente si se quiere considerar la presencia de incertidumbre, y aún más, si se busca exclusivamente un ganar-ganar. El propósito de esta tesis es extender el alcance de las estrategias de toma de decisiones con el fin de facilitar estas tareas dentro de procesos industriales. Estas contribuciones se basan en el desarrollo de modelos matemáticos eficientes que permitan coordinar grandes cantidades de información sincronizando las tareas de producción y distribución en términos económicos, ambientales y sociales. Esta tesis inicia presentando una visión global de los requerimientos de un proceso de producción sostenible, describiendo y analizando los métodos y herramientas actuales así como identificando las áreas de oportunidad más relevantes dentro del marco de ingeniería de procesos La segunda parte se enfoca en enfatizar las capacidades de las estrategias de solución multi-objetivo, durante la cual, se explora el mejoramiento de la rentabilidad de la cadena de suministro considerando múltiples objetivos bajo incertidumbres en la demanda. Particularmente, diferentes marcos de solución han sido propuestos en los que varias estrategias de toma de decisión multi-criterio han sido combinadas con aproximaciones estocásticas. Por otra parte, indicadores de rendimiento (incluyendo financiero y operacional) han sido incluidos en el mismo marco de solución para evaluar sus capacidades. Este marco fue aplicado también a problemas de cadenas de suministro descentralizados con el fin de explorar sus capacidades de producir soluciones que mejoran simultáneamente el rendimiento para cada uno de las entidades dentro de la cadena de suministro. Consecuentemente, una nueva formulación que integra varios indicadores de rendimiento en los procesos de producción fue propuesta y validada. La tercera parte de la tesis extiende el marco de solución propuesto para abordar el manejo de incertidumbres. Particularmente, la consideración de diferentes tipos y fuentes de incertidumbre (p.ej. externos e internos) fueron considerados, mediante la implementación de aproximaciones preventivas. Esta parte también explora el uso de estrategias de solución que elige eficientemente el número de escenarios necesario que representan las condiciones inciertas. Finalmente, la importancia y efecto de cada una de las fuentes de incertidumbre sobre el rendimiento del proceso es analizado en detalle mediante el uso de meta modelos que promueven el análisis de sensibilidad de dichas incertidumbres. La tercera parte de esta tesis se enfoca en la integración de las metodologías de multi-objetivo e incertidumbre anteriormente expuestas para la optimización de cadenas de suministro sostenibles. Además de la integración de diferentes métodos. Esta parte también considera la integración de diferentes niveles jerárquicos de decisión, mediante el aprovechamiento de modelos matemáticos que evalúan lasconsecuencias de considerar simultáneamente las decisiones de diseño y planeación de una cadena de suministro centralizada y descentralizada. La parte final de la tesis detalla las conclusiones y el trabajo a futuro necesario sobre esta línea de investigaciónPostprint (published version

Decision support for build-to-order supply chain management through multiobjective optimization

This is the post-print version of the final paper published in International Journal of Production Economics. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2010 Elsevier B.V.This paper aims to identify the gaps in decision-making support based on multiobjective optimization (MOO) for build-to-order supply chain management (BTO-SCM). To this end, it reviews the literature available on modelling build-to-order supply chains (BTO-SC) with the focus on adopting MOO techniques as a decision support tool. The literature has been classified based on the nature of the decisions in different part of the supply chain, and the key decision areas across a typical BTO-SC are discussed in detail. Available software packages suitable for supporting decision making in BTO supply chains are also identified and their related solutions are outlined. The gap between the modelling and optimization techniques developed in the literature and the decision support needed in practice are highlighted. Future research directions to better exploit the decision support capabilities of MOO are proposed. These include: reformulation of the extant optimization models with a MOO perspective, development of decision supports for interfaces not involving manufacturers, development of scenarios around service-based objectives, development of efficient solution tools, considering the interests of each supply chain party as a separate objective to account for fair treatment of their requirements, and applying the existing methodologies on real-life data sets.Brunel Research Initiative and Enterprise Fund (BRIEF

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems